Turning germ cells into stem cells.

Abstract:

:Primordial germ cells (PGCs), the embryonic precursors of the gametes of the adult animal, can give rise to two types of pluripotent stem cells. In vivo, PGCs can give rise to embryonal carcinoma cells, the pluripotent stem cells of testicular tumors. Cultured PGCs exposed to a specific cocktail of growth factors give rise to embryonic germ cells, pluripotent stem cells that can contribute to all the lineages of chimeric embryos including the germline. The conversion of PGCs into pluripotent stem cells is a remarkably similar process to nuclear reprogramming in which a somatic nucleus is reprogrammed in the egg cytoplasm. Understanding the genetics of embryonal carcinoma cell formation and the growth factor signaling pathways controlling embryonic germ cell derivation could tell us much about the molecular controls on developmental potency in mammals.

journal_name

Curr Opin Genet Dev

authors

Donovan PJ,de Miguel MP

doi

10.1016/j.gde.2003.08.010

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

463-71

issue

5

eissn

0959-437X

issn

1879-0380

pii

S0959437X03001217

journal_volume

13

pub_type

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