Functions of the BRCA1 and BRCA2 genes.

Abstract:

:Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but also how their loss leads to tumour formation.

journal_name

Curr Opin Genet Dev

authors

Bertwistle D,Ashworth A

doi

10.1016/s0959-437x(98)80056-7

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

14-20

issue

1

eissn

0959-437X

issn

1879-0380

pii

S0959-437X(98)80056-7

journal_volume

8

pub_type

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