Promoter proximal pausing and the control of gene expression.

Abstract:

:The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on understanding how sequence-specific, DNA-binding proteins orchestrate the actions of regulators of chromatin structure and the general transcriptional machinery to control transcription initiation. The concentration of Pol II at the 5' ends of genes indicates that key steps regulating transcription occur after Pol II has associated with a gene's promoter.

journal_name

Curr Opin Genet Dev

authors

Li J,Gilmour DS

doi

10.1016/j.gde.2011.01.010

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

231-5

issue

2

eissn

0959-437X

issn

1879-0380

pii

S0959-437X(11)00014-1

journal_volume

21

pub_type

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