Promoter proximal pausing and the control of gene expression.


:The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on understanding how sequence-specific, DNA-binding proteins orchestrate the actions of regulators of chromatin structure and the general transcriptional machinery to control transcription initiation. The concentration of Pol II at the 5' ends of genes indicates that key steps regulating transcription occur after Pol II has associated with a gene's promoter.


Curr Opin Genet Dev


Li J,Gilmour DS




Has Abstract


2011-04-01 00:00:00














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    authors: Bei M

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    authors: Kouzarides T

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    authors: Luperchio TR,Wong X,Reddy KL

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    authors: Baroux C,Pien S,Grossniklaus U

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    journal_title:Current opinion in genetics & development

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    authors: Amati B,Land H

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  • Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation.

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    authors: Strachan T

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    authors: Qian T,Shusta EV,Palecek SP

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Ranish JA,Hahn S

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Hansen LP,Crabtree GR

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    更新日期:2017-08-01 00:00:00

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Müller C,Leutz A

    更新日期:2001-04-01 00:00:00