Abstract：
:Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the use of laboratory animals, especially the mouse. While human and mouse early development present morphological resemblance, we know that the timing of the events as well as the cellular and genetic mechanisms that control fundamental processes are distinct between the species. The rapid technological development of single-cell sequencing and genome editing together with novel stem cell models of the early human embryo has made it feasible and relevant to perform functional genetic studies directly in human cells and embryos. In this review we will discuss these latest advances where combined transcriptional analysis and genome engineering has begun to shed new insights into the key processes of zygotic genome activation, lineage specification, X-chromosome inactivation and postimplantation development including primordial germ cell specification in the human embryo.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Ortega NM,Winblad N,Plaza Reyes A,Lanner Fdoi
10.1016/j.gde.2018.04.005subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1-6eissn
0959-437Xissn
1879-0380pii
S0959-437X(18)30053-4journal_volume
52pub_type
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