Functional genetics of early human development.

Abstract:

:Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the use of laboratory animals, especially the mouse. While human and mouse early development present morphological resemblance, we know that the timing of the events as well as the cellular and genetic mechanisms that control fundamental processes are distinct between the species. The rapid technological development of single-cell sequencing and genome editing together with novel stem cell models of the early human embryo has made it feasible and relevant to perform functional genetic studies directly in human cells and embryos. In this review we will discuss these latest advances where combined transcriptional analysis and genome engineering has begun to shed new insights into the key processes of zygotic genome activation, lineage specification, X-chromosome inactivation and postimplantation development including primordial germ cell specification in the human embryo.

journal_name

Curr Opin Genet Dev

authors

Ortega NM,Winblad N,Plaza Reyes A,Lanner F

doi

10.1016/j.gde.2018.04.005

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1-6

eissn

0959-437X

issn

1879-0380

pii

S0959-437X(18)30053-4

journal_volume

52

pub_type

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