Functional genetics of early human development.


:Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the use of laboratory animals, especially the mouse. While human and mouse early development present morphological resemblance, we know that the timing of the events as well as the cellular and genetic mechanisms that control fundamental processes are distinct between the species. The rapid technological development of single-cell sequencing and genome editing together with novel stem cell models of the early human embryo has made it feasible and relevant to perform functional genetic studies directly in human cells and embryos. In this review we will discuss these latest advances where combined transcriptional analysis and genome engineering has begun to shed new insights into the key processes of zygotic genome activation, lineage specification, X-chromosome inactivation and postimplantation development including primordial germ cell specification in the human embryo.


Curr Opin Genet Dev


Ortega NM,Winblad N,Plaza Reyes A,Lanner F




Has Abstract


2018-10-01 00:00:00












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    journal_title:Current opinion in genetics & development

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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  • How genetic modifiers influence the phenotype of spinal muscular atrophy and suggest future therapeutic approaches.

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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  • Reawakening the sleeping beauty in the adult brain: neurogenesis from parenchymal glia.

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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  • Physical control of tissue morphogenesis across scales.

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    pub_type: 杂志文章,评审


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    更新日期:2018-08-01 00:00:00

  • Constructive antagonism in limb development.

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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  • Recent progress in single-cell cancer genomics.

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    更新日期:2020-12-05 00:00:00

  • Micromechanics of root development in soil.

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


    authors: Dupuy LX,Mimault M,Patko D,Ladmiral V,Ameduri B,MacDonald MP,Ptashnyk M

    更新日期:2018-08-01 00:00:00

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    更新日期:1997-08-01 00:00:00

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    更新日期:2013-06-01 00:00:00

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    journal_title:Current opinion in genetics & development

    pub_type: 杂志文章,评审


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    更新日期:1991-10-01 00:00:00