Identical cells with different 3D genomes; cause and consequences?

abstract：:Much progress has been made in the past few years in understanding the mechanism and regulation of mRNA synthesis. This rapid progress has largely been due to the availability of cloned genes encoding components of the transcription machinery. Structural and biochemical studies are rapidly defining the architecture of...

journal_title：Current opinion in genetics & development

authors： Ranish JA,Hahn S

更新日期：1996-04-01 00:00:00

abstract：:Significant advances in the field of hepatocyte-specific gene expression have been made during the past year. Several new transcription factors have been cloned and partially characterized. Analyses of the promoter regions of several factors have also been initiated and Drosophila homologs for two of these factors hav...

journal_title：Current opinion in genetics & development

authors： Sladek FM,Darnell JE

更新日期：1992-04-01 00:00:00

abstract：:Folding is an important way by which epithelia are sculpted into three-dimensional shapes during development. Recent studies have integrated quantitative image analysis and physical modeling to uncover contributing mechanisms. It is becoming clear that folding processes often employ multiple mechanisms of force genera...

journal_title：Current opinion in genetics & development

authors： Denk-Lobnig M,Martin AC

更新日期：2020-08-01 00:00:00

abstract：:Current dogma holds that genes are the property of individual mammalian cells and partition between daughter cells during cell division. However, and rather unexpectedly, recent research has demonstrated horizontal cell-to-cell transfer of mitochondria and mitochondrial DNA in several mammalian cell culture systems. F...

journal_title：Current opinion in genetics & development

authors： Berridge MV,McConnell MJ,Grasso C,Bajzikova M,Kovarova J,Neuzil J

更新日期：2016-06-01 00:00:00

abstract：:The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced-yeast, worm and fly-including an analysis of the fly's influences as a model for the study of human di...

journal_title：Current opinion in genetics & development

authors： Celniker SE

更新日期：2000-12-01 00:00:00

abstract：:Morphogen gradients regulate the patterning and growth of many tissues, hence a key question is how they are established and maintained during development. Theoretical descriptions have helped to explain how gradient shape is controlled by the rates of morphogen production, spreading and degradation. These effective r...

journal_title：Current opinion in genetics & development

authors： Kicheva A,Bollenbach T,Wartlick O,Jülicher F,Gonzalez-Gaitan M

更新日期：2012-12-01 00:00:00

abstract：:The advent of the genomics age has greatly facilitated the study of crop evolution. While full-scale genome sequencing projects are underway for just a handful of crop plants, recent years have witnessed a tremendous increase in the availability of DNA sequence data for virtually all major crops. Such resources have b...

journal_title：Current opinion in genetics & development

authors： Burke JM,Burger JC,Chapman MA

更新日期：2007-12-01 00:00:00

abstract：:Ten years after the initial description of acquired immune deficiency syndrome, its causative agent, the human immunodeficiency virus, remains the subject of intense scientific interest. Recent research has focused on the detailed analysis of the molecular principles governing gene expression and virion formation and ...

journal_title：Current opinion in genetics & development

authors： Kräusslich HG

更新日期：1992-02-01 00:00:00

abstract：:The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the nematode Caenorhabditis elegans. Instead, C. elegans has a reduced and dispersed gene complement that is the result the loss of Hox genes in stages throughout its evolutionary history. The roles of Hox genes in patterning the nematode ...

journal_title：Current opinion in genetics & development

authors： Aboobaker A,Blaxter M

更新日期：2003-12-01 00:00:00

abstract：:Molecular biological techniques have contributed greatly to the study of vertebrate ocular tissues. The specification of ocular tissues has been shown to be closely related to the expression of transcription factors encoded by genes such as Pax6 and microphthalmia. Lens-specific expression of the delta 1-crystallin ge...

journal_title：Current opinion in genetics & development

authors： Kodama R,Eguchi G

更新日期：1994-10-01 00:00:00

abstract：:A number of prokaryotic and eukaryotic genomes are currently being sequenced. Already, the nucleotide sequences of four yeast chromosomes and of 2.2 Mb from Caenorhabditis elegans have been reported. Human genomic sequences have also been used in comparative studies with both mouse and Fugu rubripes. ...

journal_title：Current opinion in genetics & development

authors： Jones SJ

更新日期：1995-06-01 00:00:00

abstract：:Filamentous cyanobacteria, the only prokaryotes that form linear patterns of differentiated cells, can be genetically manipulated by the conjugative transfer of plasmids from Escherichia coli. It has become possible to determine the cellular localization of genetic transcription, including transcription of development...

journal_title：Current opinion in genetics & development

authors： Wolk CP

更新日期：1991-10-01 00:00:00

abstract：:Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagat...

journal_title：Current opinion in genetics & development

authors： Zilberman D,Henikoff S

更新日期：2005-10-01 00:00:00

abstract：:The discovery of hundreds of plant micro RNAs (miRNAs) has triggered much speculation about their potential roles in plant development. The search for plant genes involved in miRNA processing has revealed common factors such as DICER, and new molecules, including HEN1. Progress is also being made toward identifying mi...

journal_title：Current opinion in genetics & development

authors： Hunter C,Poethig RS

更新日期：2003-08-01 00:00:00

abstract：:The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the under...

journal_title：Current opinion in genetics & development

authors： Oliveri P,Davidson EH

更新日期：2004-08-01 00:00:00

abstract：:The Prader-Willi and Angelman syndromes are now well established as the paradigm of genomic imprinting in human disease. Over the past year, much has been learnt about the mechanisms by which these syndromes arise and molecular diagnostics for the majority of patients are now available. Mouse models for aspects of the...

journal_title：Current opinion in genetics & development

authors： Nicholls RD

更新日期：1993-06-01 00:00:00

abstract：:A wealth of pharmacological data point to the involvement of catecholamine metabolism in a number of psychiatric and behavioral disorders. Furthermore, evidence points to many of these affective disorders having a moderate to large genetic component. These observations have provided the impetus to search for differenc...

journal_title：Current opinion in genetics & development

authors： Mallet J,Meloni R,Laurent C

更新日期：1994-06-01 00:00:00

abstract：:Thousands of genes produce polyadenylated mRNAs that still contain one or more introns. These transcripts are known as retained intron RNAs (RI-RNAs). In the past 10 years, RI-RNAs have been linked to post-transcriptional alternative splicing in a variety of developmental contexts, but they can also be dead-end produc...

journal_title：Current opinion in genetics & development

authors： Gordon JM,Phizicky DV,Neugebauer KM

更新日期：2020-12-05 00:00:00

abstract：:Family-based next generation sequencing (NGS) has recently pointed to an important role for de novo germline point mutations in both rare and common genetic disorders associated with reduced fitness. In this review we highlight the impact of the mutational target size on the frequency of diseases caused by these de no...

journal_title：Current opinion in genetics & development

authors： de Ligt J,Veltman JA,Vissers LE

更新日期：2013-06-01 00:00:00

abstract：:Segmentation in Drosophila is a sequential process directed by at least 30 genes that encode various types of proteins, including: many transcription factors; a putative RNA-binding protein; a membrane-associated receptor kinase; several intracellular protein kinases; a number of secreted signaling molecules; and othe...

journal_title：Current opinion in genetics & development

authors： Kornberg TB,Tabata T

更新日期：1993-08-01 00:00:00

abstract：:The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in...

journal_title：Current opinion in genetics & development

authors： Stamataki E,Pavlopoulos A

更新日期：2016-08-01 00:00:00

abstract：:To control changes in shape during development, the molecular regulatory networks have to interact with the mechanical, structural components of the individual cells, in particular the cytoskeleton and the cell wall. A widely accepted hypothesis proposes that molecular regulation interferes with wall synthesis and sti...

journal_title：Current opinion in genetics & development

authors： Zhao F,Chen W,Traas J

更新日期：2018-08-01 00:00:00

abstract：:More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3-6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-function. The expanded RNA...

journal_title：Current opinion in genetics & development

authors： Zhang N,Ashizawa T

更新日期：2017-06-01 00:00:00

abstract：:Cancer remains one of the leading causes of death in the developed world and despite impressive advances in therapeutic modalities, only a small subset of patients are currently cured. The underlying genetic heterogeneity of cancers clearly plays a crucial role in determining both the clinical course of individual pat...

journal_title：Current opinion in genetics & development

authors： Pepper C,Norris K,Fegan C

更新日期：2020-02-01 00:00:00

abstract：:The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, d...

journal_title：Current opinion in genetics & development

authors： Whitfield TT

更新日期：2015-06-01 00:00:00

abstract：:The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are required to prevent carcinogenesis) as well as having possible role...

journal_title：Current opinion in genetics & development

authors： Hoeijmakers JH,Egly JM,Vermeulen W

更新日期：1996-02-01 00:00:00

abstract：:It has been shown recently that some plant transcription factors that regulate cell fate during development can traffic through plasmodesmata-the intercellular channels that connect plant cells. This phenomenon helps explain the non-autonomous effects of many developmental mutations in plants and defines a novel mecha...

journal_title：Current opinion in genetics & development

authors： Jackson D,Hake S

更新日期：1997-08-01 00:00:00

abstract：:RET mutations have been identified as the underlying cause of two congenital diseases that predominately affect tissues of neural crest origin: the MEN 2 cancer syndromes and a proportion of cases of dominantly inherited Hirschsprung disease, a disorder of gut development. This review summarizes the disease-causing mu...

journal_title：Current opinion in genetics & development

authors： Mak YF,Ponder BA

更新日期：1996-02-01 00:00:00

abstract：:During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue ...

journal_title：Current opinion in genetics & development

authors： Stooke-Vaughan GA,Campàs O

更新日期：2018-08-01 00:00:00

abstract：:We discuss recent work about cellular reprogramming during regeneration of the imaginal discs of Drosophila. These contain various lineage blocks, compartments, which express distinct genetic programmes. It has been found that after massive damage to a compartment cells from a neighbour compartment can transgress the ...

journal_title：Current opinion in genetics & development

authors： Morata G,Herrera SC

更新日期：2016-10-01 00:00:00