Abstract:
:In this review we discuss the importance of genetic somatic mosaicism and its impact on brain diseases. We start from introducing the different types of somatic mutations, their frequencies and abundances across development and lifespan. We then describe how weakness in DNA repair mechanisms influences their prevalence. Finally, we address their functional consequences in the brain and review recent research showing their unsuspected importance in several neurodevelopmental, psychiatric, and neurodegenerative diseases.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Jourdon A,Fasching L,Scuderi S,Abyzov A,Vaccarino FMdoi
10.1016/j.gde.2020.05.002subject
Has Abstractpub_date
2020-12-01 00:00:00pages
84-90eissn
0959-437Xissn
1879-0380pii
S0959-437X(20)30053-8journal_volume
65pub_type
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journal_title:Current opinion in genetics & development
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