Abstract：
:Long non-coding RNAs (ncRNAs) are emerging as important regulatory factors in mammalian genomics. A number of reports within the last 2 years have identified thousands of actively expressed long ncRNA transcripts with distinct properties. The long ncRNAs show differential expression patterns and regulation in a wide variety of cells and tissues, adding significant complexity to the understanding of their biological role. Furthermore, genome-wide studies of transcriptional enhancers based on chromatin modifications and enhancer binding proteins have led to the identification of putative enhancers and provided insight into their tissue-specific regulation of gene expression. In an exciting turn of events, new evidence is indicating that long ncRNAs are associated with enhancer regions and that such non-coding transcription correlate with the increased activity of the neighboring genes. Moreover, additional experiments suggest that enhancer-function can be mediated through a transcribed long ncRNA and that this might be a common function for long ncRNAs. Here, we review recent advances made both in the genome-wide characterization of enhancers and in the identification of new classes of long ncRNAs, and discuss the functional overlap of these two classes of regulatory elements.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Ørom UA,Shiekhattar Rdoi
10.1016/j.gde.2011.01.020subject
Has Abstractpub_date
2011-04-01 00:00:00pages
194-8issue
2eissn
0959-437Xissn
1879-0380pii
S0959-437X(11)00024-4journal_volume
21pub_type
杂志文章,评审abstract：:Cell proliferation is dependent upon the activation of receptor tyrosine kinases and integrins by soluble growth factors and extracellular matrix proteins, respectively. It is now apparent that concerted, rather than individual, signaling by these receptors is the critical feature responsible for cell-cycle progressio...
journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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更新日期：1995-06-01 00:00:00
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
doi：10.1016/j.gde.2016.06.001
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
doi：10.1016/j.gde.2017.01.002
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
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journal_title：Current opinion in genetics & development
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abstract：:D-type cyclin homologs have been found in the genomes of herpesviruses associated with neoplasias. They appear to exploit features of G(1) cyclins but extend their properties to allow for deregulation of the cell cycle. Advances in the study of the molecular basis for these novel features as well as the potential role...
journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
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journal_title：Current opinion in genetics & development
pub_type： 杂志文章,评审
doi：10.1016/j.gde.2020.02.002
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