Nuclear neighborhoods and gene expression.

abstract：:The nature-nurture argument surrounding the mechanisms of disease causation cannot be resolved, as the roles of genes and environment are inextricably entwined. Environmental fluctuation is clearly a major modifier of phenotype, as well as a promoter of evolutionary change. Both types of variability can be mediated by...

journal_title：Current opinion in genetics & development

authors： Yeyati PL,van Heyningen V

更新日期：2008-06-01 00:00:00

abstract：:In recent years, studies of cis-regulatory mechanisms have evolved from a predominant focus on promoter regions to the realization that spatial and temporal gene regulation is frequently driven by long-range enhancer clusters that operate within chromosomal compartments. This increased understanding of genome function...

journal_title：Current opinion in genetics & development

authors： Miguel-Escalada I,Pasquali L,Ferrer J

更新日期：2015-08-01 00:00:00

abstract：:Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA...

journal_title：Current opinion in genetics & development

authors： Jung H,O'Hare CM,Holt CE

更新日期：2011-08-01 00:00:00

abstract：:The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process. ...

journal_title：Current opinion in genetics & development

authors： Klobutcher LA,Jahn CL

更新日期：1991-10-01 00:00:00

abstract：:Although the protein product of the BRCA1 tumor suppressor gene has been implicated in a surprisingly diverse array of biological processes, the molecular mechanism by which BRCA1 loss promotes tumor formation remains unclear. Nonetheless, a pivotal advance has been achieved by recent studies that establish BRCA1 and ...

journal_title：Current opinion in genetics & development

authors： Baer R,Ludwig T

更新日期：2002-02-01 00:00:00

abstract：:Recognition and pairing of homologous chromosomes are absolutely required for successful segregation during meiosis. We still have no model, however, that adequately explains the mechanism of these processes in a quantitative way. The fact that homologue pairing takes similar times across several orders of magnitude i...

journal_title：Current opinion in genetics & development

authors： Moore G,Shaw P

更新日期：2009-04-01 00:00:00

abstract：:Transcription is the first step in gene expression, and its regulation underlies multicellular development and the response to environmental changes. Most studies of transcriptional regulation have focused on the recruitment of RNA polymerase to promoters. However, recent work has shown that, for many promoters, post-...

journal_title：Current opinion in genetics & development

authors： Wade JT,Struhl K

更新日期：2008-04-01 00:00:00

abstract：:Models in developmental biology continue to yield valuable insights, yet do not play a strong role as guides to experiment. This may be because of the largely unexplored complexity of most developing organisms, and the fact that the most powerful models work at a very abstract level. In Dictyostelium discoideum, howev...

journal_title：Current opinion in genetics & development

authors： Cox EC

更新日期：1992-08-01 00:00:00

abstract：:Cornelia de Lange Syndrome (CdLS) is a rare multiple malformation disorder with characteristic facial features, growth and cognitive retardation, and many other abnormalities. CdLS individuals were recently shown to have heterozygous mutations in a previously uncharacterised gene, NIPBL, which encodes delangin, a homo...

journal_title：Current opinion in genetics & development

authors： Strachan T

更新日期：2005-06-01 00:00:00

abstract：:Recent evidence suggests that dynamic three-dimensional genomic interactions in the nucleus exert critical roles in regulated gene expression. Here, we review a series of recent paradigm-shifting experiments that highlight the existence of specific gene networks within the self-organizing space of the nucleus. These g...

journal_title：Current opinion in genetics & development

authors： Nunez E,Fu XD,Rosenfeld MG

更新日期：2009-10-01 00:00:00

abstract：:Our understanding of how roots develop in soil may be at the eve of significant transformations. The formidable expansion of imaging technologies enables live observations of the rhizosphere micro-pore architecture at unprecedented resolution. Granular matter physics provides ways to understand the microscopic fluctua...

journal_title：Current opinion in genetics & development

authors： Dupuy LX,Mimault M,Patko D,Ladmiral V,Ameduri B,MacDonald MP,Ptashnyk M

更新日期：2018-08-01 00:00:00

abstract：:An epigenetic imprinting mechanism that is based on a gamete-specific methylation imprint restricts expression of a subset of mammalian genes to one parental chromosome. Recent results suggest that imprints may act only indirectly to induce monoallelic expression of coding genes. Instead, atypical non-coding RNAs appe...

journal_title：Current opinion in genetics & development

authors： Sleutels F,Barlow DP,Lyle R

更新日期：2000-04-01 00:00:00

abstract：:Control of protein synthesis (mRNA translation) is essential for proper brain development and function. Perturbations to the mechanisms governing mRNA translation have repeatedly been shown to constitute a neurodegenerative, neuropsychiatric, and neurodevelopmental disorder risk factor. Developing effective therapeuti...

journal_title：Current opinion in genetics & development

authors： Wiebe S,Nagpal A,Sonenberg N

更新日期：2020-12-01 00:00:00

abstract：:In eukaryotic cells, transcription and DNA replication occur on DNA templates associated with chromatin proteins, most notably histone octamers. Protein factors that can assemble these units have been isolated from many sources. In particular, one factor from human cells is associated with ongoing DNA synthesis; other...

journal_title：Current opinion in genetics & development

authors： Kaufman PD,Botchan MR

更新日期：1994-04-01 00:00:00

abstract：:There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals th...

journal_title：Current opinion in genetics & development

authors： Kouzarides T

更新日期：1999-02-01 00:00:00

abstract：:The initial human and chimpanzee genome sequences have been published, and additional primate genomes, including those of gorilla and orang-utan, are in progress. With these new resources, we can now address what makes our species unique, by focusing on the underlying genetic differences associated with phenotypes. Co...

journal_title：Current opinion in genetics & development

authors： Stone AC,Verrelli BC

更新日期：2006-12-01 00:00:00

abstract：:The largest subunit of eukaryotic RNA polymerase II has an unusual tandemly repeated heptapeptide sequence at its carboxyl terminus. The function of this evolutionarily conserved carboxy-terminal domain is unknown; however, new evidence links it to the formation of a large multi-component RNA polymerase II complex pos...

journal_title：Current opinion in genetics & development

authors： Emili A,Ingles CJ

更新日期：1995-04-01 00:00:00

abstract：:In 2003, a p53-expressing adenovirus was approved as a cancer therapy drug in China. Consequently, there has been a surge in the need to understand the regulation of wild type p53 function in vivo. The majority of the progress made during the past two years has focused on the cellular factors and post-translational mo...

journal_title：Current opinion in genetics & development

authors： Lu X

更新日期：2005-02-01 00:00:00

abstract：:The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure....

journal_title：Current opinion in genetics & development

authors： Engel I,Murre C

更新日期：1999-10-01 00:00:00

abstract：:Loss of cardiomyocytes from cardiovascular disease is irreversible and current therapeutic strategies do not redress the loss of myocardium after injury. The discovery that endogenous fibroblasts in the heart can be reprogrammed to cardiomyocyte-like cells after myocardial infarction and heart function is improved sub...

journal_title：Current opinion in genetics & development

authors： Srivastava D,Berry EC

更新日期：2013-10-01 00:00:00

abstract：:Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While it has long been appreciated that topographic complexities on fitness landscapes can arise only as a consequence of epistatic interactions between mutations, e...

journal_title：Current opinion in genetics & development

authors： Weinreich DM,Lan Y,Wylie CS,Heckendorn RB

更新日期：2013-12-01 00:00:00

abstract：:Considerable progress has been made in unraveling the mechanistic features of RNA editing processes in a number of genetic systems. Recent highlights include the identification of the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme as a zinc-dependent cytidine deaminase that binds to RNA, the d...

journal_title：Current opinion in genetics & development

authors： Benne R

更新日期：1996-04-01 00:00:00

abstract：:A wealth of pharmacological data point to the involvement of catecholamine metabolism in a number of psychiatric and behavioral disorders. Furthermore, evidence points to many of these affective disorders having a moderate to large genetic component. These observations have provided the impetus to search for differenc...

journal_title：Current opinion in genetics & development

authors： Mallet J,Meloni R,Laurent C

更新日期：1994-06-01 00:00:00

abstract：:Expansions of microsatellite DNA repeats contribute to the inheritance of nearly 30 developmental and neurological disorders. Significant progress has been made in elucidating the molecular mechanisms of repeat expansions using various model organisms and mammalian cell culture, and models implicating nearly all DNA t...

journal_title：Current opinion in genetics & development

authors： Kim JC,Mirkin SM

更新日期：2013-06-01 00:00:00

abstract：:Unexpected patterns of neuroblast, angioblast and myoblast movement and tissue organization have been defined using lineage tracing and transplantation methods. The most novel and enigmatic new data derive from analyses of genes in the Hox- and Pax-gene families. In addition to the characterization of expression patte...

journal_title：Current opinion in genetics & development

authors： Noden DM

更新日期：1992-08-01 00:00:00

abstract：:Human epilepsy is a common and heterogeneous condition in which genetics play an important etiological role. We begin by reviewing the past history of epilepsy genetics, a field that has traditionally included studies of pedigrees with epilepsy caused by defects in ion channels and neurotransmitters. We highlight impo...

journal_title：Current opinion in genetics & development

authors： Poduri A,Lowenstein D

更新日期：2011-06-01 00:00:00

abstract：:All the aspects of transcription are controlled by complexes that modify or remodel chromatin at the level of individual genes, gene clusters, or whole chromosomes. The MSL complex that is responsible for dosage compensation in Drosophila is an example of complexes that operate at the whole-chromosome level on the tra...

journal_title：Current opinion in genetics & development

authors： Lucchesi JC

更新日期：2009-12-01 00:00:00

abstract：:Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chrom...

journal_title：Current opinion in genetics & development

authors： de la Chapelle A,Peltomäki P

更新日期：1998-06-01 00:00:00

abstract：:Logical models provide insight about key control elements of biological networks. Based solely on the logical structure, we can determine state transition diagrams that give the allowed possible transitions in a coarse grained phase space. Attracting pathways and stable nodes in the state transition diagram correspond...

journal_title：Current opinion in genetics & development

authors： Glass L,Siegelmann HT

更新日期：2010-12-01 00:00:00

abstract：:In the past ten years, there has been increasing recognition that cells can acquire genetic variants during cortical development that can give rise to brain malformations as well as nonlesional focal epilepsy. These often brain tissue-specific, de novo variants can result in highly variable phenotypes based on the bur...

journal_title：Current opinion in genetics & development

authors： Heinzen EL

更新日期：2020-12-01 00:00:00