Abstract：
:To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue deformation dynamics remains incompletely understood. We here introduce our recent work on the reconstruction of tissue deformation dynamics in chick limb development from cell lineage tracing data. This analysis has revealed globally-aligned anisotropic tissue deformation along the proximo-distal axis not only in the distal region but also in the whole limb bud. This result points to a need, as a future challenge, to find oriented molecular/cellular behaviors for realizing the observed anisotropic tissue deformation in both proximal and distal regions, which will lead to systems understanding of limb morphogenesis.
journal_name
Curr Opin Genet Devjournal_title
Current opinion in genetics & developmentauthors
Suzuki T,Morishita Ydoi
10.1016/j.gde.2017.04.005subject
Has Abstractpub_date
2017-08-01 00:00:00pages
108-114eissn
0959-437Xissn
1879-0380pii
S0959-437X(16)30223-4journal_volume
45pub_type
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