Abstract：
:Amyloid beta-protein (Abeta) self-assembly is linked strongly to Alzheimer's disease. We found that PP-Leu, a tridecapeptide analogue of broad-spectrum antiviral peptides termed theta-defensins, potently inhibits Abeta oligomer and fibril formation. This effect appeared to be mediated through sequestration of the amyloidogenic Abeta peptide in colloid-like assemblies. PP-Leu comprises a turn formed by a d-Pro-l-Pro amino acid dyad and stabilized by a disulfide bond, a motif that was exceptionally resistant to endoproteinase K digestion. This combination of assembly inhibitory activity and protease resistance suggests that PP-Leu may have potential therapeutic value.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Yamin G,Ruchala P,Teplow DBdoi
10.1021/bi901325gsubject
Has Abstractpub_date
2009-12-08 00:00:00pages
11329-31issue
48eissn
0006-2960issn
1520-4995journal_volume
48pub_type
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