Abstract：
:Affinity-labeling experiments with 125I-endothelin derivatives using bifunctional cross-linking reagents were carried out in an attempt to identify the polypeptide component(s) of the endothelin/sarafotoxin receptors in rat brain tissues. In rat cerebellum, cortex, and caudate putamen, endothelin 1 specifically labeled a major component with a molecular mass of around 53,000. In the same tissues endothelin 3 specifically labeled, in addition to the 53,000 band, a band of molecular mass of 38,000. This result clearly indicates that in the brain the endothelin binding site resides within a polypeptide of apparent Mr = 53,000. The possible presence of receptor subtypes is discussed with reference also to the reported identification of endothelin receptors in chick cardiac membrane and in rat mesangial cells.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Ambar I,Kloog Y,Sokolovsky Mdoi
10.1021/bi00479a012subject
Has Abstractpub_date
1990-07-10 00:00:00pages
6415-8issue
27eissn
0006-2960issn
1520-4995journal_volume
29pub_type
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