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Twenty-one percent partial hepatectomy. In vivo rat model for the study of liver regeneration.

Abstract：

:We describe a new model of submaximal stimulation of liver regeneration in the rat. Removal of the right lateral lobes in the rat produced a 21% hepatectomy. The measurement accuracy of the incorporation rate of [14C]thymidine into DNA 24 h after 21% hepatectomy (n = 32) was less than that after the standard 34% hepatectomy (n = 32), with S.D./mean being 35% and 130%, respectively (F-test, p less than 0.025). This model was able to detect regeneration-stimulation activity present in liver cytosol extract and serum of 68% hepatectomized rats. Using this model we identified a subfraction of rat serum achieved after treatment of serum with ethanol and ion-exchange column, which had a highly stimulatory effect. Stimulation obtained with serum from hepatectomized pigs showed that these factors are not species specific.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Baruch Y,Frith LO,Kirsch RE

doi

10.1016/0168-8278(91)90833-w

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

316-20

issue

3

eissn

0168-8278

issn

1600-0641

pii

0168-8278(91)90833-W

journal_volume

12

pub_type

杂志文章

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