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Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial.

Abstract：

BACKGROUND/AIMS:The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial. METHODS:A total of 103 patients with grade I-III acute hepatic encephalopathy were randomized to receive rifaximin (50 patients, 1200 mg/day) or lactitol (53 patients, 60 g/day) for 5-10 days. Changes in the portal-systemic encephalopathy (PSE) index on entry and at the end of the study were used to evaluate the efficacy of the two therapies. RESULTS:Both groups were comparable before treatment with regard to demographic data and characteristics of the hepatic encephalopathy episode. The global efficacy of both therapies was similar: 81.6% in the rifaximin group and 80.4% in the lactitol group showed improvement or total regression of the episode. A significantly better evolution of the PSE index was observed in the rifaximin group, due to a greater effect of rifaximin in two components of the index: EEG abnormalities and ammonia levels. No serious adverse events related to either treatment were found during the study. CONCLUSIONS:Rifaximin may be considered a useful and safe alternative therapy to lactitol in the treatment of acute hepatic encephalopathy in cirrhosis.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Mas A,Rodés J,Sunyer L,Rodrigo L,Planas R,Vargas V,Castells L,Rodríguez-Martínez D,Fernández-Rodríguez C,Coll I,Pardo A,Spanish Association for the Study of the Liver Hepatic Encephalopathy Cooperative Group.

doi

10.1016/s0168-8278(02)00350-1

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

51-8

issue

1

eissn

0168-8278

issn

1600-0641

pii

S0168827802003501

journal_volume

38

pub_type

临床试验,杂志文章,随机对照试验

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