Alteration of protein glycosylation in liver diseases.

abstract：BACKGROUND & AIMS:The pathomechanisms underlying non-alcoholic fatty liver disease (NAFLD) and the involved molecular regulators are incompletely explored. The nuclear factor-kappa B (NF-κB)-cofactor gene B cell leukemia-3 (Bcl-3) plays a critical role in altering the transcriptional capacity of NF-κB - a key inducer o...

journal_title：Journal of hepatology

authors： Gehrke N,Wörns MA,Huber Y,Hess M,Straub BK,Hövelmeyer N,Waisman A,Kim YO,Schuppan D,Galle PR,Schattenberg JM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND/AIMS:Selective cyclooxygenase (COX)-2 inhibitors do not adversely affect renal function in experimental cirrhosis. In the current study, we investigated the molecular mechanisms underlying the effects of the selective COX-2 inhibitor, celecoxib, and assessed the influence of albumin on its actions. METHODS:...

journal_title：Journal of hepatology

authors： López-Parra M,Clària J,Titos E,Planagumà A,Párrizas M,Masferrer JL,Jiménez W,Arroyo V,Rivera F,Rodés J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other but the causal inter-relationships between them remain incompletely understood. We aimed to explore the causal relationships between the 3 diseases. METHODS:Using both UK Biob...

journal_title：Journal of hepatology

authors： Liu Z,Zhang Y,Graham S,Wang X,Cai D,Huang M,Pique-Regi R,Dong XC,Chen YE,Willer C,Liu W

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

journal_title：Journal of hepatology

authors： Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND & AIMS:Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on the release of fibrogenic extracellular vesicles (EVs) by platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) remain...

journal_title：Journal of hepatology

authors： Gao J,Wei B,de Assuncao TM,Liu Z,Hu X,Ibrahim S,Cooper SA,Cao S,Shah VH,Kostallari E

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND/AIMS:To relate severity of intoxication with allyl alcohol and acetaminophen to modulated hepatic gene expression of liver functions and regeneration. METHODS:Rats fasted for 12 h received acetaminophen 3.5 or 5.6 g per kg body weight, or allyl alcohol 100 or 125 microl by gastric tube, doses producing no a...

journal_title：Journal of hepatology

authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIMS:No information is yet available about the influence of alcohol abuse on the translocation of larger molecules (Mr>1200) through the intestinal mucosa in man. The present study aimed to determine the intestinal permeability to macromolecules in patients with chronic alcohol abuse and mild to more advance...

journal_title：Journal of hepatology

authors： Parlesak A,Schäfer C,Schütz T,Bode JC,Bode C

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND/AIMS:Combinations of beta-blockers and vasodilators have been assessed for their ability to lower portal pressure and so prevent variceal haemorrhage. However, reservations have been raised particularly with respect to renal function and perfusion after the use of these medicines in patients with chronic liv...

journal_title：Journal of hepatology

authors： Forrest EH,Bouchier IA,Hayes PC

更新日期：1996-12-01 00:00:00

abstract：:Endoscopic ultrasonography was performed in 80 cirrhotic patients and 50 control subjects. The aim of the study was to describe and classify the vascular abnormalities of the gastric wall as observed on echoendoscopy in cirrhotic patients and to compare the data with endoscopy. The size of gastric varices was classifi...

journal_title：Journal of hepatology

authors： Boustière C,Dumas O,Jouffre C,Letard JC,Patouillard B,Etaix JP,Barthélémy C,Audigier JC

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to identify human liver proteins that are associated with different stages of liver development. METHODS:We collected liver samples from 14 fetuses between 14 and 41 weeks of development, one child and four adults. Proteins which exhibited consistent and significant variations...

journal_title：Journal of hepatology

authors： Brizard JP,Ramos J,Robert A,Lafitte D,Bigi N,Sarda P,Laoudj-Chenivesse D,Navarro F,Blanc P,Assenat E,Maurel P,Pascussi JM,Vilarem MJ

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND & AIMS:Neonatal sclerosing cholangitis (NSC) is a severe neonatal-onset cholangiopathy commonly leading to liver transplantation (LT) for end-stage liver disease in childhood. Liver biopsy findings histopathologically resemble those in biliary atresia (BA); however, in NSC extrahepatic bile ducts are patent,...

journal_title：Journal of hepatology

authors： Grammatikopoulos T,Sambrotta M,Strautnieks S,Foskett P,Knisely AS,Wagner B,Deheragoda M,Starling C,Mieli-Vergani G,Smith J,University of Washington Center for Mendelian Genomics.,Bull L,Thompson RJ

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. METHODS...

journal_title：Journal of hepatology

authors： Zhang S,Song X,Cao D,Xu Z,Fan B,Che L,Hu J,Chen B,Dong M,Pilo MG,Cigliano A,Evert K,Ribback S,Dombrowski F,Pascale RM,Cossu A,Vidili G,Porcu A,Simile MM,Pes GM,Giannelli G,Gordan J,Wei L,Evert M,Cong W,C

更新日期：2017-12-01 00:00:00

abstract：:A substantial production of prostaglandin E2 (PGE2) was induced in primary cultures of rat Kupffer cells by zymosan, calcium ionophore A23187, phorbol ester and arachidonic acid, whereas contact with latex particles, glucan or immunocomplexes led to a minor PGE2 release only. Superoxide generation, on the other hand, ...

journal_title：Journal of hepatology

authors： Dieter P,Schulze-Specking A,Decker K

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study is to verify the efficacy and safety of peg-interferon alfa-2b in combination with ribavirin for initial treatment of HCV-associated mixed cryoglobulinemia. METHODS:Eighteen patients (7 women and 11 men) affected by mixed cryoglobulinemia were included in the study and treated wit...

journal_title：Journal of hepatology

authors： Mazzaro C,Zorat F,Caizzi M,Donada C,Di Gennaro G,Maso LD,Carniello G,Virgolini L,Tirelli U,Pozzato G

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

journal_title：Journal of hepatology

authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

更新日期：1997-10-01 00:00:00

abstract：:The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a di...

journal_title：Journal of hepatology

authors： Singal AG,Lampertico P,Nahon P

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/AIMS:The MAGE, GAGE and BAGE genes encode tumor antigens recognized by autologous cytotoxic T lymphocytes. The aim of this study was to evaluate the possibility of using these genes as molecular markers and as the targets of specific immunotherapy for human hepatocellular carcinoma (HCC). METHODS:The expres...

journal_title：Journal of hepatology

authors： Kobayashi Y,Higashi T,Nouso K,Nakatsukasa H,Ishizaki M,Kaneyoshi T,Toshikuni N,Kariyama K,Nakayama E,Tsuji T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND/AIMS:The purpose of this study was to compare the epidemiological, biochemical, virological and histological characteristics of patients with chronic hepatitis B and C with those of patients suffering from chronic hepatitis C alone. METHODS:Twenty-three patients with chronic hepatitis C, who were anti-HCV p...

journal_title：Journal of hepatology

authors： Zarski JP,Bohn B,Bastie A,Pawlotsky JM,Baud M,Bost-Bezeaux F,Tran van Nhieu J,Seigneurin JM,Buffet C,Dhumeaux D

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND & AIMS:In developed countries, hepatitis E is usually associated with travelling to endemic areas, but a growing number of sporadic cases are also seen in patients with no travel history. The aim of this study was to assess the impact and the molecular epidemiology of hepatitis E in Italy. METHODS:Between J...

journal_title：Journal of hepatology

authors： Romanò L,Paladini S,Tagliacarne C,Canuti M,Bianchi S,Zanetti AR

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Phase I/II studies of 4 weeks duration have confirmed the ALT lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality o...

journal_title：Journal of hepatology

authors： Orlent H,Hansen BE,Willems M,Brouwer JT,Huber R,Kullak-Ublick GA,Gerken G,Zeuzem S,Nevens F,Tielemans WC,Zondervan PE,Lagging M,Westin J,Schalm SW

更新日期：2006-10-01 00:00:00

abstract：:The effect of amphotericin B on hepatic microsomal cytochrome P-450 (P-450) concentration was measured in vitro, in vivo and ex vivo in the rat. In vitro, both amphotericin B (0-500 micrograms/ml) and its vehicle, sodium deoxycholate (0-410 micrograms/ml), caused similar dose-dependent decreases of P-450 concentration...

journal_title：Journal of hepatology

authors： Heidemann H,Holzlöhner U,Heydemann J,Freitag T,Inselmann G

更新日期：1992-03-01 00:00:00

abstract：:In this study plasma free fatty acids and adipose tissue fatty acid composition in 10 cirrhotic patients, 5 patients with non-cirrhotic chronic liver disease and in 5 controls have been investigated. Fatty acid composition of adipose tissue in cirrhotic patients demonstrated a significant increase of 16:1 and a decrea...

journal_title：Journal of hepatology

authors： Merli M,Iapichino S,Bolognese A,Bruni A,Cantafora A,Riggio O,Capocaccia L

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Platelet cytosolic calcium is necessary for normal platelet function, and may reflect intracellular signalling in vascular smooth muscle cells. METHODS:The cytosolic calcium of platelets from patients with cirrhosis and control subjects was measured in contact with plasma from either source, using FURA 2AM....

journal_title：Journal of hepatology

authors： Forrest EH,Dillon JF,Campbell TJ,Newsome PN,Hayes PC

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:The prognosis of patients with chronic liver disease is to a great extent determined by the presence and degree of portal hypertension (PHT). Hepatic venous pressure gradient (HVPG) has been shown to be an accurate prognostic index in patients with cirrhosis. Transient elastography is a non-invasive p...

journal_title：Journal of hepatology

authors： Robic MA,Procopet B,Métivier S,Péron JM,Selves J,Vinel JP,Bureau C

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND/AIM:Restitution of periportal liver necrosis induced by allyl alcohol involves proliferation and differentiation of putative liver stem cells. The participation of different non-epithelial cell types required to restore the liver cord structure in this process has not been well documented. The aim of the stu...

journal_title：Journal of hepatology

authors： Yin L,Lynch D,Sell S

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND/AIMS:The x gene of hepatitis B virus encodes a transactivating factor of 154 amino acids, termed HBx, which stimulates transcription of multiple viral and cellular genes. The transactivating function is probably associated with a tumorigenic potential of HBx, since x gene sequences, encoding functional HBx, ...

journal_title：Journal of hepatology

authors： Renner M,Haniel A,Bürgelt E,Hofschneider PH,Koch W

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

journal_title：Journal of hepatology

authors： Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Eastern American woodchuck (Marmota monax), naturally infected with woodchuck hepatitis virus, a virus similar to human hepatitis B virus, develops liver cancer with a high prevalence. AIMS:The aim of this work was to assess Marmota monax as a model of human hepatocellular carcinoma, especially to assess ne...

journal_title：Journal of hepatology

authors： Gouillat C,Manganas D,Zoulim F,Vitrey D,Saguier G,Guillaud M,Ain JF,Duque-Campos R,Jamard C,Praves M,Trepo C

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatobiliary malignancies are frequently seen in primary sclerosing cholangitis (PSC) and they complicate the evaluation of patients and timing of liver transplantation. METHODS:Data from all Nordic PSC patients listed for liver transplantation during 1990-2001 were recorded prospectively. Predictors ...

journal_title：Journal of hepatology

authors： Brandsaeter B,Isoniemi H,Broomé U,Olausson M,Bäckman L,Hansen B,Schrumpf E,Oksanen A,Ericzon BG,Höckerstedt K,Mäkisalo H,Kirkegaard P,Friman S,Bjøro K

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:Primary biliary cirrhosis (PBC) is an autoimmune cholestatic liver disease thought to develop through a complex interaction of genetic and environmental factors. It is characterised by T-cell-mediated non-suppurative destructive cholangitis. We have studied the polymorphic cytotoxic T lymphocyte-associat...

journal_title：Journal of hepatology

authors： Agarwal K,Jones DE,Daly AK,James OF,Vaidya B,Pearce S,Bassendine MF

更新日期：2000-04-01 00:00:00