Fatty acid composition of adipose tissue in patients with chronic liver disease.

abstract：:Calcium concentrations in pig livers were serially estimated following ischemia-reperfusion. Ischemia was produced by clamping the hepatic artery and the portal vein for 90 min (Group 1, n = 6) or for 180 min (Group 2, n = 6) during temporary side-to-side portacaval shunt performed before the induction of ischemia. Al...

journal_title：Journal of hepatology

authors： Uchida M,Takemoto Y,Nagasue N,Kimoto T,Dhar DK,Nakamura T

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

journal_title：Journal of hepatology

authors： Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND/AIMS:Liver negative-strand hepatitis C virus (HCV) RNA is the most direct indicator of active viral replication but has only been examined in a few semiquantitative studies. METHODS:Positive- and negative-strand HCV RNA in the right (R) and left (L) liver lobes was quantified by rTth-based strand-specific r...

journal_title：Journal of hepatology

authors： Yuki N,Matsumoto S,Tadokoro K,Mochizuki K,Kato M,Yamaguchi T

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND/AIMS:Vaccination strategies able to induce strong T-cell responses might contribute to eradicate hepatitis C virus (HCV) infection. We previously demonstrated that fusion of an antigen to the extra domain A from fibronectin (EDA) targets the antigen to TLR4-expressing dendritic cells (DC) and improves its im...

journal_title：Journal of hepatology

authors： Mansilla C,Gorraiz M,Martinez M,Casares N,Arribillaga L,Rudilla F,Echeverria I,Riezu-Boj JI,Sarobe P,Borrás-Cuesta F,Prieto J,Lasarte JJ

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model. METHODS...

journal_title：Journal of hepatology

authors： Zhang S,Song X,Cao D,Xu Z,Fan B,Che L,Hu J,Chen B,Dong M,Pilo MG,Cigliano A,Evert K,Ribback S,Dombrowski F,Pascale RM,Cossu A,Vidili G,Porcu A,Simile MM,Pes GM,Giannelli G,Gordan J,Wei L,Evert M,Cong W,C

更新日期：2017-12-01 00:00:00

abstract：:In situ hybridization with oligonucleotide probes has been used to localise hepatitis A virus RNA genomic sequences in formalin-fixed and routinely processed human liver biopsies from three patients. Using radiolabelled Sulphur-35 antisense probes, viral genomic sequences were found in all three cases, but signal inte...

journal_title：Journal of hepatology

authors： Taylor M,Goldin RD,Ladva S,Scheuer PJ,Thomas HC

更新日期：1994-03-01 00:00:00

abstract：:The liver contributes to immune surveillance against pathogens entering via the gut and is itself influenced by alterations in mucosal immune responses and the microbiome. Mucosal immunity is also implicated in autoimmune liver diseases that associate with inflammatory bowel disease (IBD), and in steatohepatitis where...

journal_title：Journal of hepatology

authors： Trivedi PJ,Adams DH

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND & AIMS:Given an appreciable risk of adverse-effects, current therapies for chronic hepatitis C virus (HCV) infection pose a dilemma to patients. We explored, via simulation modelling, patient-important benefits of attaining a sustained viral response (SVR). METHODS:We created the HCV Individualised Treatmen...

journal_title：Journal of hepatology

authors： Innes H,Goldberg D,Dusheiko G,Hayes P,Mills PR,Dillon JF,Aspinall E,Barclay ST,Hutchinson SJ

更新日期：2014-06-01 00:00:00

abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

journal_title：Journal of hepatology

authors： Weeder PD,van Rijn R,Porte RJ

更新日期：2015-07-01 00:00:00

abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

journal_title：Journal of hepatology

authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

更新日期：1991-01-01 00:00:00

abstract：:Familial hypobetalipoproteinemia (FHBL) is an monogenic co-dominant disorder characterized by reduced plasma levels of cholesterol, low density lipoproteins (LDL) and apolipoprotein B (apoB) often associated with non-alcoholic fatty liver disease (NAFLD). It has been suggested that FHBL might predispose to gallstone d...

journal_title：Journal of hepatology

authors： Lancellotti S,Zaffanello M,Di Leo E,Costa L,Lonardo A,Tarugi P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) incidence among HIV-positive men who have sex with men (MSM) has increased since 2000, although there are regional differences. We aimed to 1) estimate trends in HCV incidence among HIV-positive MSM, 2) assess the association between incidence and geographical region, age and H...

journal_title：Journal of hepatology

authors： van Santen DK,van der Helm JJ,Del Amo J,Meyer L,D'Arminio Monforte A,Price M,Béguelin CA,Zangerle R,Sannes M,Porter K,Geskus RB,Prins M,CASCADE Collaboration in EuroCoord.

更新日期：2017-08-01 00:00:00

abstract：:In this report we describe the case of a 7-year-old boy, suffering from autoimmune-type chronic active hepatitis (AI-CAH) associated with vitiligo, nail dystrophy, alopecia areata and a variant of liver kidney microsomal (LKM) autoantibodies. This patient's antibodies are different from LKM-1 which are directed agains...

journal_title：Journal of hepatology

authors： Sacher M,Blümel P,Thaler H,Manns M

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND/AIMS:The pathogenic relevance of the hepatitis G virus (HGV) and its sensitivity to interferon are currently under investigation. This study aimed to investigate the prevalence of HGV infection in patients with chronic hepatitis C and to elucidate if HGV co-infection modifies the clinical course and the resp...

journal_title：Journal of hepatology

authors： Sáiz JC,Ampurdanés S,Olmedo E,López-Labrador FX,Forns X,Guilera M,Tassies D,Costa J,Sánchez-Tapias JM,Jiménez de Anta MT,Rodés J

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND & AIMS:Current techniques for predicting outcome and requirement for emergency liver transplantation (ELT) in acute liver failure (ALF) are imperfect, though The Kings College Criteria (KCC) are the most commonly applied tools for this purpose. Their performance in identification of patients with non-paracet...

journal_title：Journal of hepatology

authors： McPhail MJ,Wendon JA,Bernal W

更新日期：2010-09-01 00:00:00

abstract：:The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...

journal_title：Journal of hepatology

authors： Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

更新日期：1992-03-01 00:00:00

abstract：:We measured the number and the morphometric characteristics of perisinusoidal cells in perfusion-fixed biopsy samples from 7 control patients with normal liver histology. On 1-micron section, the number of cells was 18 +/- 1.5/0.1 mm2; 25% of cells did not apparently contain lipids. There were no significant zonal dif...

journal_title：Journal of hepatology

authors： Sztark F,Dubroca J,Latry P,Quinton A,Balabaud C,Bioulac-Sage P

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis B virus can cause serious problems in individuals undergoing organ transplantation. The aim of this study was to evaluate the hepatic events among HBs-Ag positive recipients and HBs-Ag negative recipients who received products from hepatitis B virus carriers. METHODS:A total of 151 patients r...

journal_title：Journal of hepatology

authors： Ustün C,Idilman R,Gürman G,Ozcan M,Akyol G,Akan H,Ilhan O,Beksaç M,Uysal A,Konuk N,Karayalçin S,Poyraz A,Van Thiel D,Koç H

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND & AIMS:Recently, we have shown that micro-metastases, in the hypoxic transition zone surrounding lesions generated by radiofrequency ablation (RFA), display strongly accelerated outgrowth. CD95 is best known for its ability to induce apoptosis but can also promote tumorigenesis in apoptosis-resistant tumor c...

journal_title：Journal of hepatology

authors： Nijkamp MW,Hoogwater FJ,Steller EJ,Westendorp BF,van der Meulen TA,Leenders MW,Borel Rinkes IH,Kranenburg O

更新日期：2010-12-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared the safety, tolerabi...

journal_title：Journal of hepatology

authors： Shouval D,Ashur Y,Adler R,Lewis JA,Miller W,Kuter B,Brown L,Nalin DR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Liver carbohydrate metabolism and blood flow are regulated by hepatic nerves and hormones such as glucagon, insulin or catecholamines. Acute and chronic application of alcohol are known to depress the function of central and peripheral nerves. The extent of inhibition of the autonomic nervous system is ...

journal_title：Journal of hepatology

authors： Kucera T,Stümpel F,Jungermann K

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:Intestinal microflora plays an important role in the pathogenesis of neonatal jaundice by inhibiting enterosystemic circulation of bilirubin. The present study aimed to investigate the influence of intestinal microflora on serum bilirubin levels in hyperbilirubinemic Gunn rats. METHODS:After a baseline...

journal_title：Journal of hepatology

authors： Vítek L,Zelenka J,Zadinová M,Malina J

更新日期：2005-02-01 00:00:00

abstract：:Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

journal_title：Journal of hepatology

authors： Morgan MY,Hawley KE,Stambuk D

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

journal_title：Journal of hepatology

authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND/AIMS:After liver transplantation for autoimmune hepatitis, the long-term results and the incidence of recurrence of primary disease are unknown. METHODS:In this retrospective study we reviewed the clinical course of 25 patients transplanted for autoimmune hepatitis and followed for a mean of 5.3 years (2-8....

journal_title：Journal of hepatology

authors： Ratziu V,Samuel D,Sebagh M,Farges O,Saliba F,Ichai P,Farahmand H,Gigou M,Féray C,Reynès M,Bismuth H

更新日期：1999-01-01 00:00:00

abstract：:We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but i...

journal_title：Journal of hepatology

authors： van 't Wout JW,Herrmann WA,de Vries RA,Stricker BH

更新日期：1994-07-01 00:00:00

abstract：:Symptomatic hepatic involvement is a rare complication of hereditary hemorrhagic telangiectasia and most commonly consists of fibrosis or cirrhosis. We describe a 33-year-old woman in whom multiple hepatic arteriovenous malformations led to high output cardiac failure and liver failure due to biliary necrosis with ref...

journal_title：Journal of hepatology

authors： Bauer T,Britton P,Lomas D,Wight DG,Friend PJ,Alexander GJ

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to sequence the precore region of HBV isolated from serum and tumorous and non-tumorous liver tissue from patients with hepatocellular carcinoma to identify mutations that might play a role in malignant transformation. METHODS:HBV DNA was extracted from 62 sera, 14 tumorous and...

journal_title：Journal of hepatology

authors： Kramvis A,Kew MC,Bukofzer S

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:Based on the observation of biphasic induction of SGK1 expression in the regenerating liver, we investigated the role of SGK1 in the regulation of MEK/ERK signaling pathway which plays a crucial role in regulating growth and survival signaling. METHODS:To determine the role of SGK1 in the activation of...

journal_title：Journal of hepatology

authors： Won M,Park KA,Byun HS,Kim YR,Choi BL,Hong JH,Park J,Seok JH,Lee YH,Cho CH,Song IS,Kim YK,Shen HM,Hur GM

更新日期：2009-07-01 00:00:00

abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

journal_title：Journal of hepatology

authors： Stremmel W

更新日期：1989-11-01 00:00:00