Safety, tolerability, and immunogenicity of an inactivated hepatitis A vaccine: effects of single and booster injections, and comparison to administration of immune globulin.

abstract：:Alcohol use disorders (AUDs) is one of the leading causes of disease and disability in almost all European countries. Among the alcohol-related diseases, alcoholic liver disease (ALD) is the most common. At present, alcohol is the most frequent cause of liver cirrhosis in the Western world. The cornerstone of treatmen...

journal_title：Journal of hepatology

authors： Addolorato G,Mirijello A,Barrio P,Gual A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIMS:Selective cyclooxygenase (COX)-2 inhibitors do not adversely affect renal function in experimental cirrhosis. In the current study, we investigated the molecular mechanisms underlying the effects of the selective COX-2 inhibitor, celecoxib, and assessed the influence of albumin on its actions. METHODS:...

journal_title：Journal of hepatology

authors： López-Parra M,Clària J,Titos E,Planagumà A,Párrizas M,Masferrer JL,Jiménez W,Arroyo V,Rivera F,Rodés J

更新日期：2005-01-01 00:00:00

abstract：Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...

journal_title：Journal of hepatology

authors： Wang Y,Liu S,Liu H,Li W,Lin F,Jiang L,Li X,Xu P,Zhang L,Zhao L,Cao Y,Kang J,Yang J,Li L,Liu X,Li Y,Nie R,Mu J,Lu F,Zhao S,Lu J,Zhao J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND/AIMS:Liver carbohydrate metabolism and blood flow are regulated by hepatic nerves and hormones such as glucagon, insulin or catecholamines. Acute and chronic application of alcohol are known to depress the function of central and peripheral nerves. The extent of inhibition of the autonomic nervous system is ...

journal_title：Journal of hepatology

authors： Kucera T,Stümpel F,Jungermann K

更新日期：1997-01-01 00:00:00

abstract：:The global scenario of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent th...

journal_title：Journal of hepatology

authors： Rizzetto M,Hamid S,Negro F

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) is a major etiologic agent of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The aim of this study was to elucidate pathological effects of HCV-core protein on liver cells. METHODS:We have generated transgenic mice carrying HCV-core cDNA (Px-core) and pathologically...

journal_title：Journal of hepatology

authors： Honda A,Hatano M,Kohara M,Arai Y,Hartatik T,Moriyama T,Imawari M,Koike K,Yokosuka O,Shimotohno K,Tokuhisa T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIMS:To analyze the kinetics of the hepatitis C virus and the patterns of resistance to interferon alpha, we assessed HCV RNA levels early during retreatment with high-dose interferon in patients who did not respond to standard treatment. METHODS:Eleven non-responders to previous therapy with 3-6 MU interfe...

journal_title：Journal of hepatology

authors： Bekkering FC,Brouwer JT,Leroux-Roels G,Van Vlierberghe H,Elewaut A,Schalm SW

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sus...

journal_title：Journal of hepatology

authors： Mannaerts I,Leite SB,Verhulst S,Claerhout S,Eysackers N,Thoen LF,Hoorens A,Reynaert H,Halder G,van Grunsven LA

更新日期：2015-09-01 00:00:00

abstract：:Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainme...

journal_title：Journal of hepatology

authors： Sherman M

更新日期：2009-12-01 00:00:00

abstract：:Twenty-two patients with primary biliary cirrhosis were treated with ursodeoxycholic acid, 10 mg/kg per day. Fourteen patients with stages I/II were treated for 4-12 years (mean 7.5), and eight patients with stages III/IV for 5-12 years (mean 6.5). Twelve of 13 patients with early stages became asymptomatic. Aminotran...

journal_title：Journal of hepatology

authors： Leuschner U,Güldütuna S,Imhof M,Hübner K,Benjaminov A,Leuschner M

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND/AIMS:Intestinal microflora plays an important role in the pathogenesis of neonatal jaundice by inhibiting enterosystemic circulation of bilirubin. The present study aimed to investigate the influence of intestinal microflora on serum bilirubin levels in hyperbilirubinemic Gunn rats. METHODS:After a baseline...

journal_title：Journal of hepatology

authors： Vítek L,Zelenka J,Zadinová M,Malina J

更新日期：2005-02-01 00:00:00

abstract：:Short- and long-term effects of intraperitoneally transplanted microcarrier attached liver cells (MAL) have been studied in two experimental models of severe liver insufficiency in the rat: subtotal hepatectomy (HX) and acute liver ischemia. Intraperitoneal transplantation of MAL immediately after subtotal hepatectomy...

journal_title：Journal of hepatology

authors： Bosman DK,de Haan JG,Smit J,Jorning GG,Maas MA,Chamuleau RA

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:Non alcoholic steatohepatitis (NASH) has no approved pharmacological therapy. Insulin sensitisers such as thiazolidinediones ameliorate insulin resistance and are a potential therapeutic option. We performed a systematic review and meta-analysis of the effect of thiazolidinediones on histological and ...

journal_title：Journal of hepatology

authors： Mahady SE,Webster AC,Walker S,Sanyal A,George J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large-scale genome sequencing analyses on BTCs to investigate t...

journal_title：Journal of hepatology

authors： Wardell CP,Fujita M,Yamada T,Simbolo M,Fassan M,Karlic R,Polak P,Kim J,Hatanaka Y,Maejima K,Lawlor RT,Nakanishi Y,Mitsuhashi T,Fujimoto A,Furuta M,Ruzzenente A,Conci S,Oosawa A,Sasaki-Oku A,Nakano K,Tanaka H,Yam

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIMS:Protein-L-isoaspartyl methyltransferase (PIMT) is a methyltransferase that plays a crucial role in the repair of damaged proteins. In this study, we investigated whether ethanol exposure causes an accumulation of modified proteins bearing atypical isoaspartyl residues that may be related to impaired PIM...

journal_title：Journal of hepatology

authors： Kharbanda KK,Mailliard ME,Baldwin CR,Sorrell MF,Tuma DJ

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND/AIMS:We have developed a gene therapy strategy based on the observation that insulin-like growth factor I (IGF-I) is necessary for the acquisition and maintenance of the transformed phenotype in hepatocarcinoma. This strategy consists in transfecting the rat hepatoma cell line with an episomal vector express...

journal_title：Journal of hepatology

authors： Ellouk-Achard S,Djenabi S,De Oliveira GA,Desauty G,Duc HT,Zohair M,Trojan J,Claude JR,Sarasin A,Lafarge-Frayssinet C

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to assess the pathology and pathogenic mechanisms involved in the occlusion of transjugular intrahepatic portosystemic stent-shunts. METHODS:Thirty-four patients with transjugular intrahepatic portosystemic stent-shunt who had at least two portographic assessments of shunt func...

journal_title：Journal of hepatology

authors： Jalan R,Harrison DJ,Redhead DN,Hayes PC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND/AIMS:Circulatory abnormalities with activation of vasoconstrictor systems after large-volume paracentesis are generally considered secondary to an increased extravasation of fluid from the intravascular compartment to the extravascular space with subsequent reduction in plasma volume. To test this hypothesis...

journal_title：Journal of hepatology

authors： Saló J,Ginès A,Ginès P,Piera C,Jiménez W,Guevara M,Fernández-Esparrach G,Sort P,Bataller R,Arroyo V,Rodés J

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND/AIMS:The mechanism by which many cytochrome P450 (CYP) isozymes decrease during liver regeneration is unclear. Peptides and growth factors are thought to be involved. Putrescine, the first polyamine synthesised by ornithine decarboxylase, peaks early following partial hepatectomy and is known to play an esse...

journal_title：Journal of hepatology

authors： Favre C,Monti JA,Scapini C,Pellegrino J,Carnovale CE,Carrillo MC

更新日期：1998-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

journal_title：Journal of hepatology

authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

更新日期：2018-02-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucose dolichyl-phosphate glucosyltransferase and bile acid glucosyltransferase were quantitatively determined in subcellular fractions obtained by differential centrifugation of human liver homogenate. Both enzymes were exclusively enriched in the microsomal fraction with a recovery of total e...

journal_title：Journal of hepatology

authors： Gartung C,Matern S,Matern H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIM:Endothelin-1 plays an important role in the regulation of portal hypertension; endothelin antagonists have been extensively studied in portal hypertensive animals. We aimed to evaluate the efficacy of highly selective endothelin antagonists in partial portal vein ligated (PPVL) rats. METHODS:Four groups...

journal_title：Journal of hepatology

authors： De Gottardi A,Shaw S,Sägesser H,Reichen J

更新日期：2000-11-01 00:00:00

abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...

journal_title：Journal of hepatology

authors： Sagnelli E,Stroffolini T,Ascione A,Bonino F,Chiaramonte M,Colombo M,Craxi A,Giusti G,Manghisi OG,Pastore G

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND/AIMS:Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior. METHODS:In this study, genome-wide aberrations in 13 cases of cholan...

journal_title：Journal of hepatology

authors： Wong N,Li L,Tsang K,Lai PB,To KF,Johnson PJ

更新日期：2002-11-01 00:00:00

abstract：:The effect of glucagon on the relation between urea synthesis and blood amino acid concentration was studied in seven healthy volunteers. Alanine was given as prime-continuous infusions and, after 1 hr for equilibration, the urea nitrogen synthesis rate was measured in two periods of about 2 hrs as urinary excretion c...

journal_title：Journal of hepatology

authors： Vilstrup H,Hansen BA,Almdal TP

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND & AIMS:Despite the clinical and genetic significance of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC), its characteristics on imaging have not been described. This study aimed to characterise MTM-HCC on gadoxetic acid-enhanced MRI and to evaluate the diagnostic accuracy and prognostic value of t...

journal_title：Journal of hepatology

authors： Rhee H,Cho ES,Nahm JH,Jang M,Chung YE,Baek SE,Lee S,Kim MJ,Park MS,Han DH,Choi JY,Park YN

更新日期：2021-01-01 00:00:00

abstract：:The present study was conducted to evaluate if the increased rate of apoptosis previously reported in the liver of ethanol-treated rats was accompanied by increased cell renewal. A quantitative analysis of apoptosis was performed in rats fed an ethanol-containing liquid diet for 5 weeks. S-phase cells were demonstrate...

journal_title：Journal of hepatology

authors： Baroni GS,Marucci L,Benedetti A,Mancini R,Jezequel AM,Orlandi F

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND & AIMS:The liver is a crucial organ at the crossroads of iron and glucose metabolism. The aim of the study was to assess intra-hepatic iron in young patients with non-alcoholic fatty liver disease (NAFLD) and its association with insulin resistance and severity of liver damage. METHODS:Intrahepatic iron con...

journal_title：Journal of hepatology

authors： Manco M,Alisi A,Real JF,Equitani F,DeVito R,Valenti L,Nobili V

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIMS:Central nervous system abnormalities such as fatigue and depression occur more frequently in chronic hepatitis C virus (HCV) infection than in many other causes of chronic liver disease. The finding that fatigue is unrelated to activity of hepatitis or mode of infection could indicate an independent eff...

journal_title：Journal of hepatology

authors： Kramer L,Bauer E,Funk G,Hofer H,Jessner W,Steindl-Munda P,Wrba F,Madl C,Gangl A,Ferenci P

更新日期：2002-09-01 00:00:00

abstract：:Serotonin or 5-hydroxytryptamine (5-HT) is known to regulate several key aspects of liver biology and these functions include hepatic blood flow, innervation and wound healing. Given the importance of these functions it is surprising that relatively little time has been dedicated to studying the precise function and m...

journal_title：Journal of hepatology

authors： Ruddell RG,Mann DA,Ramm GA

更新日期：2008-04-01 00:00:00