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Remodelling of calcium signalling during liver regeneration in the rat.

Abstract：

BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during liver regeneration. RESULTS:We observed two phases in which the hepatocyte response to calcium-mobilising agonists was greatly reduced versus control cells at 24h and five days after partial hepatectomy. We found that both phases of hepatocyte desensitisation involved the down-regulation of cell surface receptors and the type II InsP3 receptor. Single cell studies with flash photolysis of caged InsP3 revealed that InsP3-mediated Ca2+ release was slower in regenerating hepatocytes at 24, 48 h and 5 days than in control cells. Also, the temporal pattern of vasopressin-elicited intracellular calcium oscillations studied on fura2-loaded cells was altered, with the duration of each Ca2+ peak being longer. Finally, we showed an association between hepatocyte desensitisation and progression through the cell cycle towards the S phase at 24 h after hepatectomy. CONCLUSIONS:Our study supports the remodelling of hepatocyte calcium signalling during liver regeneration, and that this change is partly linked with cell cycle progression.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

doi

10.1016/j.jhep.2006.08.014

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

247-56

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(06)00499-5

journal_volume

46

pub_type

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