Hepatitis B virus genotypes, core gene variability and ethnicity in the Pacific region.

Abstract:

BACKGROUND/AIMS:The world-wide distribution of hepatitis B virus (HBV) genotypes follows a geographic pattern under the influence of ethnic background. METHODS:Forty eight core genes from four pacific islands were compared with the following findings. RESULTS:First, island-specific variant substitutions were found for only two out of four islands. Second, 11 amino acid and 90 nucleotide changes specific for pacific genotypes C and D were defined. Third, the nucleotide diversity of genotype C (all but one were silent) was greater than that of genotype D. CONCLUSIONS:These results suggest an early appearance of genotype C in the pacific with few subsequent amino acid changes because of shared immunological responses across the region followed by random silent changes, some of which reflect isolation of individual island populations. Genotype D appeared later.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Jazayeri MS,Basuni AA,Cooksley G,Locarnini S,Carman WF

doi

10.1016/j.jhep.2004.03.025

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

139-46

issue

1

eissn

0168-8278

issn

1600-0641

pii

S0168827804001394

journal_volume

41

pub_type

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