Delayed and prolonged cholestatic hepatitis with ductopenia after long-term ciprofloxacin therapy for Crohn's disease.

abstract：:The presence of hepatitis B virus DNA (HBV-DNA) in the peripheral blood mononuclear cells (PBMC) of 29 anti-HIV symptomless carriers (eleven HBeAg positive, eleven anti-HBe positive and seven HBsAg negative) and of 40 anti-human immunodeficiency virus (HIV)-negative patients (15 HBeAg positive, 15 anti-HBe positive an...

journal_title：Journal of hepatology

authors： Bartolomé FJ,Moraleda G,Castillo I,Martinez MG,Porres JC,Carreño V

更新日期：1990-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

journal_title：Journal of hepatology

authors： Lonardo A,Nascimbeni F,Mantovani A,Targher G

更新日期：2018-02-01 00:00:00

abstract：:Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying the diversity of CCA growth patterns remain a key issue of clinical concern. Crucial questions comp...

journal_title：Journal of hepatology

authors： Raggi C,Invernizzi P,Andersen JB

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIM:Liver cirrhosis is accompanied by a fall in whole-body protein turnover and alterations of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. However, the influence of liver cirrhosis on the GH/IGF-1 axis in the perioperative period, and the contribution of the GH/IGF-1 axis alteration in...

journal_title：Journal of hepatology

authors： Inaba T,Saito H,Inoue T,Han I,Furukawa S,Matsuda T,Ikeda S,Muto T

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND/AIMS:Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition. METHODS:Systemic and splanchnic hemodynamics, plasma renin activity and plasma concentration of interleukin-6, serum ...

journal_title：Journal of hepatology

authors： Fernández J,Navasa M,Garcia-Pagan JC,G-Abraldes J,Jiménez W,Bosch J,Arroyo V

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND/AIMS:Alamifovir is a purine nucleotide analogue prodrug that shows potent activity against wild type and lamivudine resistant hepatitis B virus in preclinical studies. The aim of this study was to assess the safety and potential antiviral effects of alamifovir in humans. METHODS:A randomised, placebo contro...

journal_title：Journal of hepatology

authors： Soon DK,Lowe SL,Teng CH,Yeo KP,McGill J,Wise SD

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND/AIMS:To study the effect of short-term cholestasis on glycogen metabolism. METHODS:Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON). RESULTS:Four days after surgery, the hepatic glycogen conten...

journal_title：Journal of hepatology

authors： Lang C,Schäfer M,Varga L,Zimmermann A,Krähenbühl S,Krähenbühl L

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim was to study the reproducibility of magnetic resonance velocity mapping, when measuring portal vein and superior mesenteric artery blood flow, under fasting and post-prandial conditions. Magnetic resonance flow measurements for the portal vein were compared with echo-Doppler measurements in the ...

journal_title：Journal of hepatology

authors： Lycklama à Nijeholt GJ,Burggraaf K,Wasser MN,Schultze Kool LJ,Schoemaker RC,Cohen AF,de Roos A

更新日期：1997-02-01 00:00:00

abstract：AIM/METHODS:To elucidate the metabolic effect of interferon alpha, the following tests were performed on 14 patients with chronic active hepatitis C before and after interferon therapy (6 million units/day for 2 weeks): (1) oral glucose tolerance tests to measure insulin secretion; (2) euglycemic hyperinsulinemic clamp...

journal_title：Journal of hepatology

authors： Imano E,Kanda T,Ishigami Y,Kubota M,Ikeda M,Matsuhisa M,Kawamori R,Yamasaki Y

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND & AIMS:Treating HCV infection reduces overall mortality and reduces the risk of multiple extrahepatic complications. Whether the reduction in mortality is primarily due to a reduction in liver-related causes or extrahepatic complications is unknown. METHODS:We identified HCV-positive individuals treated for...

journal_title：Journal of hepatology

authors： Butt AA,Yan P,Shaikh OS,Lo Re V 3rd,Abou-Samra AB,Sherman KE

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of chronic liver disease. Brain monoamines have been implicated in the pathogenesis of HE. We examined the relationship between monoamine dysfunction and the degree of portal-systemic shunting (PSS) in rats with varying degrees of PS...

journal_title：Journal of hepatology

authors： Lozeva V,Montgomery JA,Tuomisto L,Rocheleau B,Pannunzio M,Huet PM,Butterworth RF

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatocyte growth factor (HGF) plays an important role as a mitogen in liver regeneration. However, little is known about the metabolic effects of HGF in the liver. Studies were performed to examine whether HGF influences carbohydrate metabolism, which is drastically changed in the early course of the r...

journal_title：Journal of hepatology

authors： Kaibori M,Kwon AH,Teshima S,Nakanishi H,Kitano T,Kamiyama Y,Okumura T

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

journal_title：Journal of hepatology

authors： Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

更新日期：1998-01-01 00:00:00

abstract：:As growth hormone possesses anabolic properties that are active on protein metabolism, and thus of potential benefit to patients with chronic liver disease, we determined the metabolic effects of recombinant human growth hormone on insulin-like growth factor-I (IGF-I) its specific binding proteins, and liver function....

journal_title：Journal of hepatology

authors： Møller S,Becker U,Grønbaek M,Juul A,Winkler K,Skakkebaek NE

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:Adherence to antiviral treatment is important to achieve sustained virological response (SVR) in chronic hepatitis C (CHC). We evaluated the efficiency of a multidisciplinary support programme (MSP), based on published HIV treatment experience, to increase patient adherence and the efficacy of pegylat...

journal_title：Journal of hepatology

authors： Carrión JA,Gonzalez-Colominas E,García-Retortillo M,Cañete N,Cirera I,Coll S,Giménez MD,Márquez C,Martin-Escudero V,Castellví P,Navinés R,Castaño JR,Galeras JA,Salas E,Bory F,Martín-Santos R,Solà R

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from...

journal_title：Journal of hepatology

authors： Bankwitz D,Doepke M,Hueging K,Weller R,Bruening J,Behrendt P,Lee JY,Vondran FWR,Manns MP,Bartenschlager R,Pietschmann T

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIMS:HCV infection recurs almost in all HCV-positive patients receiving liver transplantation and carries a poor prognosis. Aim of this study was to analyze efficacy and effect on survival of antiviral therapy in this clinical setting. METHODS:Pegylated-interferon alpha-2b and ribavirin were administered at...

journal_title：Journal of hepatology

authors： Picciotto FP,Tritto G,Lanza AG,Addario L,De Luca M,Di Costanzo GG,Lampasi F,Tartaglione MT,Marsilia GM,Calise F,Cuomo O,Ascione A

更新日期：2007-03-01 00:00:00

abstract：:Interleukin-2, a product of helper T cells, is essentially involved in the regulation of cell-mediated immunity. Two monocyte-derived factors, interleukin-1 and prostaglandin E2, influence interleukin-2 synthesis with opposite actions. To analyse immunoregulatory function in HBsAg-positive chronic active hepatitis, T ...

journal_title：Journal of hepatology

authors： Civeira M,Prieto J,Morte S,Riñon M,Serrano M

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The expression and the distribution of fibrillin-1 and elastin were studied in normal and pathological human liver samples. METHODS:As controls, histologically normal/subnormal liver samples (n = 24) were used. Pathological samples corresponded to seven cirrhosis and eight hepatocellular carcinomas (HCC) de...

journal_title：Journal of hepatology

authors： Dubuisson L,Lepreux S,Bioulac-Sage P,Balabaud C,Costa AM,Rosenbaum J,Desmoulière A

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND/AIMS:S-adenosylmethionine (SAM) is a thiol-containing compound with known therapeutic affects on cholestasis and hepatotoxicity. The aim of this study was to investigate the effect of SAM on the prevention of mitochondrial injury induced by hepatic ischemia and reperfusion. METHODS/RESULTS:Rats were subject...

journal_title：Journal of hepatology

authors： Jeon BR,Lee SM

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:Treatment of hepatorenal syndrome (HRS) is based on vasoconstrictors. Terlipressin is the one with the soundest evidence. Noradrenalin has been suggested as an effective alternative. The current study was aimed at assessing the efficacy and safety of noradrenalin vs terlipressin in patients with HRS. M...

journal_title：Journal of hepatology

authors： Alessandria C,Ottobrelli A,Debernardi-Venon W,Todros L,Cerenzia MT,Martini S,Balzola F,Morgando A,Rizzetto M,Marzano A

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND/AIMS:A variety of data suggest that microbial infections and, in particular, atypical mycobacteria infections, may either initiate and/or be associated with the pathogenesis of primary biliary cirrhosis. METHODS:To address this hypothesis, use was made of polymerase chain reaction techniques and primers spe...

journal_title：Journal of hepatology

authors： Tanaka A,Prindiville TP,Gish R,Solnick JV,Coppel RL,Keeffe EB,Ansari A,Gershwin ME

更新日期：1999-10-01 00:00:00

abstract：:An impairment in the renal capacity to excrete water is a common finding in patients with cirrhosis and ascites. In some patients this abnormality is minor since it is only detectable by measuring urine volume or free water clearance after a water load and is not associated with changes in plasma osmolality and serum ...

journal_title：Journal of hepatology

authors： Ginès P,Jiménez W

更新日期：1996-04-01 00:00:00

abstract：:In this report we describe the case of a 7-year-old boy, suffering from autoimmune-type chronic active hepatitis (AI-CAH) associated with vitiligo, nail dystrophy, alopecia areata and a variant of liver kidney microsomal (LKM) autoantibodies. This patient's antibodies are different from LKM-1 which are directed agains...

journal_title：Journal of hepatology

authors： Sacher M,Blümel P,Thaler H,Manns M

更新日期：1990-05-01 00:00:00

abstract：:Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in dri...

journal_title：Journal of hepatology

authors： Bosma A,Seifert WF,van Thiel-de Ruiter GC,van Leeuwen RE,Blauw B,Roholl P,Knook DL,Brouwer A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIMS:Interferon (IFN) with ribavirin combination therapy (CT) was proposed for the treatment of hepatitis C recurring in liver transplants. We assessed the efficacy of two protocols of CT in transplanted patients with recurrent severe hepatitis C virus (HCV) hepatitis. METHODS:Fifty-seven patients (68% geno...

journal_title：Journal of hepatology

authors： Lavezzo B,Franchello A,Smedile A,David E,Barbui A,Torrani M,Ottobrelli A,Zamboni F,Fadda M,Bobbio A,Salizzoni M,Rizzetto M

更新日期：2002-08-01 00:00:00

abstract：:The effect of amphotericin B on hepatic microsomal cytochrome P-450 (P-450) concentration was measured in vitro, in vivo and ex vivo in the rat. In vitro, both amphotericin B (0-500 micrograms/ml) and its vehicle, sodium deoxycholate (0-410 micrograms/ml), caused similar dose-dependent decreases of P-450 concentration...

journal_title：Journal of hepatology

authors： Heidemann H,Holzlöhner U,Heydemann J,Freitag T,Inselmann G

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Current techniques for predicting outcome and requirement for emergency liver transplantation (ELT) in acute liver failure (ALF) are imperfect, though The Kings College Criteria (KCC) are the most commonly applied tools for this purpose. Their performance in identification of patients with non-paracet...

journal_title：Journal of hepatology

authors： McPhail MJ,Wendon JA,Bernal W

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Hormone replacement therapy (HRT) prevents osteoporosis in postmenopausal women by inhibiting bone resorption, but the benefits of oestrogen therapy in liver transplant patients have not been studied. METHODS:The effect of transdermal HRT was studied in 33 postmenopausal liver transplant women. The mai...

journal_title：Journal of hepatology

authors： Isoniemi H,Appelberg J,Nilsson CG,Mäkelä P,Risteli J,Höckerstedt K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND & AIMS:Non-selective beta blockers (NSBBs) have been shown to have deleterious outcomes in patients with refractory ascites, alcoholic hepatitis and spontaneous bacterial peritonitis leading many physicians to stop the drug in these cases. Acute-on-chronic liver failure (ACLF) is characterized by systemic in...

journal_title：Journal of hepatology

authors： Mookerjee RP,Pavesi M,Thomsen KL,Mehta G,Macnaughtan J,Bendtsen F,Coenraad M,Sperl J,Gines P,Moreau R,Arroyo V,Jalan R,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2016-03-01 00:00:00