Improvement of C3A cell metabolism for usage in bioartificial liver support systems.

abstract：BACKGROUND/AIMS:Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro in pure cultures of these cells. METHODS:We investigated whether Kupffer cells in the liver slice are still responsive to an inflammatory stimulus of lipopolysacch...

journal_title：Journal of hepatology

authors： Olinga P,Merema MT,de Jager MH,Derks F,Melgert BN,Moshage H,Slooff MJ,Meijer DK,Poelstra K,Groothuis GM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND & AIMS:Patients listed with exception points for hepatocellular carcinoma (HCC) have been more likely to be transplanted than those listed for chronic liver failure (LF) based on the model for end-stage liver disease (MELD) score. The aim of this study was to determine outcomes in the 5-year experience of a ...

journal_title：Journal of hepatology

authors： Bhat M,Ghali P,Dupont B,Hilzenrat R,Tazari M,Roy A,Chaudhury P,Alvarez F,Carrier M,Bilodeau M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the present study was to compare MELD score, Child-Turcotte-Pugh (CTP) score, modified Maddrey's Discriminant Function (DF) score, and the related variables in predicting in-hospital mortality of patients with alcoholic hepatitis. METHODS:A retrospective chart review and statistical analyses...

journal_title：Journal of hepatology

authors： Srikureja W,Kyulo NL,Runyon BA,Hu KQ

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

journal_title：Journal of hepatology

authors： Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

journal_title：Journal of hepatology

authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND/AIMS:The immunological response of ducks to acute infection with duck hepatitis B virus (DHBV) has not been fully characterised. In this study the relationship between viral dose and the outcome of infection in immune competent 26-day-old ducks was examined. METHODS:Indirect ELISA assays were developed to d...

journal_title：Journal of hepatology

authors： Vickery K,Cossart Y

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND/AIMS:This study assesses the safety, pharmacokinetics and efficacy of transarterial chemoembolization using drug eluting beads (DEB), an embolizing device that slowly releases chemotherapy to decrease systemic toxicity. METHODS:Twenty-seven Child-Pugh A cirrhotics (76% male, 59% HCV) with untreated large/mu...

journal_title：Journal of hepatology

authors： Varela M,Real MI,Burrel M,Forner A,Sala M,Brunet M,Ayuso C,Castells L,Montañá X,Llovet JM,Bruix J

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND/AIMS:As conditional knockout mice for stat3 are impaired in liver regeneration after partial hepatectomy while those for gp130 have defects in early STAT3 phosphorylation but have normal DNA synthesis, late STAT3 phosphorylation induced independently of gp130 seems to be essential for liver regeneration. Sin...

journal_title：Journal of hepatology

authors： Seki E,Kondo Y,Iimuro Y,Naka T,Son G,Kishimoto T,Fujimoto J,Tsutsui H,Nakanishi K

更新日期：2008-02-01 00:00:00

abstract：AIMS/METHODS:Bile acid kinetics and biliary lipid composition were studied in seven patients, aged 17-70 years with cystic fibrosis. All patients were of normal height and weight, and were in good clinical condition. Ultrasonography indicated a small gallbladder in one and non-visualized gallbladder in two patients. Se...

journal_title：Journal of hepatology

authors： Strandvik B,Einarsson K,Lindblad A,Angelin B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND/AIMS:Platelet function abnormalities contribute to the hemostatic defect in patients with cirrhosis. In this study we evaluated the occurrence of in vivo platelet activation as a possible mechanism of defective platelet aggregation in patients with cirrhosis. METHODS:Nine patients with severe (Child B-C) ci...

journal_title：Journal of hepatology

authors： Laffi G,Cinotti S,Filimberti E,Ciabattoni G,Caporale R,Marra F,Melani L,Grossi A,Carloni V,Gentilini P

更新日期：1996-04-01 00:00:00

abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

journal_title：Journal of hepatology

authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND/AIMS:Nephropathy associated with alpha1-antitrypsin deficiency is assumed to be an unusual entity. We describe the case of a 23-year-old woman with severe alpha1-antitrypsin (PiZ homozygosity) deficiency who developed hepatic cirrhosis in childhood, and glomerulonephritis and nephrotic syndrome in adult life...

journal_title：Journal of hepatology

authors： Elzouki AN,Lindgren S,Nilsson S,Veress B,Eriksson S

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

journal_title：Journal of hepatology

authors： Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sus...

journal_title：Journal of hepatology

authors： Mannaerts I,Leite SB,Verhulst S,Claerhout S,Eysackers N,Thoen LF,Hoorens A,Reynaert H,Halder G,van Grunsven LA

更新日期：2015-09-01 00:00:00

abstract：:Progressive familial intrahepatic cholestasis 2 is an autosomal-recessive disorder caused by mutations in the ABCB11 gene, which encodes the bile salt export pump (BSEP). Recurrence of BSEP deficiency after liver transplantation is caused by the development of anti-BSEP antibodies. Antibody-induced BSEP deficiency is ...

journal_title：Journal of hepatology

authors： Brinkert F,Pukite I,Krebs-Schmitt D,Briem-Richter A,Stindt J,Häussinger D,Keitel V,Müller I,Grabhorn E

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND & AIM:Alcohol consumption increases intestinal permeability and causes damage to hepatocytes, leading to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs), stimulating hepatic macrophages and activating NF-κB. The resultant inflammation exacerbates alcoholic liver d...

journal_title：Journal of hepatology

authors： Wang M,Shen G,Xu L,Liu X,Brown JM,Feng D,Ross RA,Gao B,Liangpunsakul S,Ju C

更新日期：2017-09-21 00:00:00

abstract：BACKGROUND/AIMS:To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels. METHODS:A nationwide prospective study was started in 1997. Four Italian centres have participated in this study. RESULTS:Eight hundred a...

journal_title：Journal of hepatology

authors： Puoti C,Castellacci R,Montagnese F,Zaltron S,Stornaiuolo G,Bergami N,Bellis L,Precone DF,Corvisieri P,Puoti M,Minola E,Gaeta GB

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinoma (CCA) represents a primary hepatic malignancy with incidence and mortality rising globally. Surgical treatment has remained the only potentially curative treatment option, but it is still unclear which patients benefit most from extended liver surgery, highlighting the need for new ...

journal_title：Journal of hepatology

authors： Loosen SH,Roderburg C,Kauertz KL,Pombeiro I,Leyh C,Benz F,Vucur M,Longerich T,Koch A,Braunschweig T,Ulmer TF,Heidenhain C,Tacke F,Binnebösel M,Schmeding M,Trautwein C,Neumann UP,Luedde T

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIMS:We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma. METHODS:We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones. RESULTS:Freq...

journal_title：Journal of hepatology

authors： Katoh H,Shibata T,Kokubu A,Ojima H,Loukopoulos P,Kanai Y,Kosuge T,Fukayama M,Kondo T,Sakamoto M,Hosoda F,Ohki M,Imoto I,Inazawa J,Hirohashi S

更新日期：2005-11-01 00:00:00

abstract：:Liver transplantation is performed successfully across major HLA differences between donor and recipient. This may be influenced by the organ specific expression of major histocompatibility complex (MHC) molecules which determine the local immune reactivity and rejection response. The tissue expression of MHC molecule...

journal_title：Journal of hepatology

authors： Steinhoff G

更新日期：1990-07-01 00:00:00

abstract：:The mechanism responsible for liver cell necrosis in patients with hepatitis A is not known. Since the type of hepatic lesions and the clinical presentation of acute hepatitis B are similar and are probably related to the cell-mediated immune response to a viral antigen located in the liver cell, it is possible that a...

journal_title：Journal of hepatology

authors： Fasel-Folley J,Overby LR,Frei PC

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

journal_title：Journal of hepatology

authors： Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND & AIM:Hydrogen peroxide-inducible clone-5 (Hic-5), also named as transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1), was found to be induced by TGF-β. Previous studies have shown that TGF-β is a principal mediator of hepatic stellate cell (HSC) activation in liver fibrosis. However, thi...

journal_title：Journal of hepatology

authors： Lei XF,Fu W,Kim-Kaneyama JR,Omoto T,Miyazaki T,Li B,Miyazaki A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to identify preoperative magnetic resonance (MR) imaging biomarkers for predicting microvascular invasion (MVI), to determine their diagnostic performance and to evaluate whether they are associated with early recurrence after surgery for single hepatocellular carcinoma (HCC). METHOD...

journal_title：Journal of hepatology

authors： Lee S,Kim SH,Lee JE,Sinn DH,Park CK

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guideli...

journal_title：Journal of hepatology

authors： Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi M

更新日期：2012-04-01 00:00:00

abstract：:TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies invivo, we show here that TGR5 sign...

journal_title：Journal of hepatology

authors： Jansen PL

更新日期：2010-06-01 00:00:00

abstract：:This study reports that thrombocytopenia is a universal phenomenon post hepatic transplantation. In 53 consecutive adult patients undergoing liver transplantation the platelet count fell by a mean of 63% (157 x 10(9)/l to 50 x 10(9)/l). The platelet count reached a nadir at Day 5 post-transplant but returned to pre-op...

journal_title：Journal of hepatology

authors： McCaughan GW,Herkes R,Powers B,Rickard K,Gallagher ND,Thompson JF,Sheil AG

更新日期：1992-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Journal of hepatology

authors： Arai T,Kato Y,Ishimoto K,Kanai M,Shinjo S,Sayama K,Suzuki T,Doi T,Johnson RS,Suematsu M,Goda N

更新日期：2015-02-10 00:00:00

abstract：:Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by a reduced hepatic activity of uroporphynogen decarboxylase (URO-D), an enzyme of the heme synthesis. The clinical features of PCT may be brought into light by hepatic injury induced by hepatitis C virus (HCV). A significant association between HCV ...

journal_title：Journal of hepatology

authors： Thevenot T,Bachmeyer C,Hammi R,Dumouchel P,Ducamp-Posak I,Cadranel JF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of th...

journal_title：Journal of hepatology

authors： Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM

更新日期：2013-07-01 00:00:00