The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.


BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of the Mediterranean diet (MD), a diet high in monounsaturated fatty acids, on steatosis and insulin sensitivity, using gold standard techniques. METHODS:Twelve non-diabetic subjects (6 Females/6 Males) with biopsy-proven NAFLD were recruited for a randomised, cross-over 6-week dietary intervention study. All subjects undertook both the MD and a control diet, a low fat-high carbohydrate diet (LF/HCD), in random order with a 6-week wash-out period in- between. Insulin sensitivity was determined with a 3-h hyperinsulinemic-euglycemic clamp study and hepatic steatosis was assessed with localized magnetic resonance (1)H spectroscopy ((1)H-MRS). RESULTS:At baseline, subjects were abdominally obese with elevated fasting concentrations of glucose, insulin, triglycerides, ALT, and GGT. Insulin sensitivity at baseline was low (M=2.7 ± 1.0 mg/kg/min(-1)). Mean weight loss was not different between the two diets (p=0.22). There was a significant relative reduction in hepatic steatosis after the MD compared with the LF/HCD: 39 ± 4% versus 7 ± 3%, as measured by (1)H-MRS (p=0.012). Insulin sensitivity improved with the MD, whereas after the LF/HCD there was no change (p=0.03 between diets). CONCLUSIONS:Even without weight loss, MD reduces liver steatosis and improves insulin sensitivity in an insulin-resistant population with NAFLD, compared to current dietary advice. This diet should be further investigated in subjects with NAFLD.


J Hepatol


Journal of hepatology


Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM




Has Abstract


2013-07-01 00:00:00














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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Miska S,Günther S,Vassilev M,Meisel H,Pape G,Will H

    更新日期:1993-04-01 00:00:00

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    authors: Morita Y,Sakaguchi T,Ikegami K,Goto-Inoue N,Hayasaka T,Hang VT,Tanaka H,Harada T,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Murakami M,Setou M,Konno H

    更新日期:2013-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Yasuda I,Shiratori Y,Adachi S,Obora A,Takemura M,Okuno M,Shidoji Y,Seishima M,Muto Y,Moriwaki H

    更新日期:2002-05-01 00:00:00

  • Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

    abstract:BACKGROUND & AIMS:Hallmarks of non-alcoholic fatty liver disease (NAFLD) are increased triglyceride accumulation within hepatocytes. The prevalence of NAFLD increases steadily with increasing thyrotropin (TSH) levels. However, the underlying mechanisms are largely unknown. Here, we focused on exploring the effect and m...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Yan F,Wang Q,Lu M,Chen W,Song Y,Jing F,Guan Y,Wang L,Lin Y,Bo T,Zhang J,Wang T,Xin W,Yu C,Guan Q,Zhou X,Gao L,Xu C,Zhao J

    更新日期:2014-12-01 00:00:00

  • Chronic cholestatic diseases.

    abstract::Chronic cholestatic diseases, whether occurring in infancy, childhood or adulthood, are characterized by defective bile acid transport from the liver to the intestine, which is caused by primary damage to the biliary epithelium in most cases. In this article, approaches to diagnosis and management of the main specific...

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    authors: Poupon R,Chazouillères O,Poupon RE

    更新日期:2000-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

    更新日期:2002-04-01 00:00:00

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    abstract:BACKGROUND/AIMS:Septins are ubiquitous and multifunctional scaffold proteins involved in cytoskeletal organization, exocytosis and other cellular processes. We disclose the quiescent hepatic stellate cells (HSCs)-specific expression of a septin subunit Sept4 in the liver, and explore the significance of the septin syst...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Iwaisako K,Hatano E,Taura K,Nakajima A,Tada M,Seo S,Tamaki N,Sato F,Ikai I,Uemoto S,Kinoshita M

    更新日期:2008-11-01 00:00:00

  • Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats.

    abstract:BACKGROUND/AIMS:To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure. METHODS:Four-week-old female LEC rats were divided into the untreated and treated groups. The latter wa...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Tsubota A,Yoshikawa T,Nariai K,Mitsunaga M,Yumoto Y,Fukushima K,Hoshina S,Fujise K

    更新日期:2008-03-01 00:00:00

  • Monitoring cholesterol crystallization from lithogenic model bile by time-lapse density gradient ultracentrifugation.

    abstract:BACKGROUND/AIMS:Cholesterol crystallization in a dilute, bile salt-rich model bile is a multiphase process in which early filamentous crystals gradually transform to classical cholesterol monohydrate plates. The pertinence of similar transformations in more complex model systems or native bile is, however, unclear. The...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Konikoff FM,Laufer H,Messer G,Gilat T

    更新日期:1997-03-01 00:00:00

  • Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

    更新日期:2012-07-01 00:00:00

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    abstract::The global scenario of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent th...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Rizzetto M,Hamid S,Negro F

    更新日期:2021-01-20 00:00:00

  • Effect of amphotericin B on hepatic cytochrome P-450 and glucose-6-phosphatase in the rat.

    abstract::The effect of amphotericin B on hepatic microsomal cytochrome P-450 (P-450) concentration was measured in vitro, in vivo and ex vivo in the rat. In vitro, both amphotericin B (0-500 micrograms/ml) and its vehicle, sodium deoxycholate (0-410 micrograms/ml), caused similar dose-dependent decreases of P-450 concentration...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Heidemann H,Holzlöhner U,Heydemann J,Freitag T,Inselmann G

    更新日期:1992-03-01 00:00:00

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    abstract:BACKGROUND/AIMS:The molecules involved in the progression of hepatocellular carcinoma (HCC) are not fully understood. The aim of this study was to elucidate the crucial genes involved in cancer progression and metastasis. METHODS:Selectively expressed genes were screened using differential display analysis, and then f...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kanetaka K,Sakamoto M,Yamamoto Y,Yamasaki S,Lanza F,Kanematsu T,Hirohashi S

    更新日期:2001-11-01 00:00:00

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    abstract::We previously reported that high-dose ursodeoxycholate (UDC) infusion in rats resulted in extensive glucuronidation of UDC, and speculated that the glucuronidation causes bicarbonate-rich hypercholeresis induced by UDC (Takikawa, H., Sano, N., Narita, T. and Yamanaka, M. Hepatology 1990; 11: 743-749). To test this hyp...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Takikawa H,Sano N,Minagawa K,Yamanaka M

    更新日期:1992-05-01 00:00:00

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    abstract::In a multicentre trial, 82 patients known to be hepatitis B e antigen and hepatitis B virus DNA positive for at least 1 year, with elevated serum alanine aminotransferase levels and chronic liver lesions on biopsy, were randomized to receive either recombinant interferon alfa-2a at a dose of 4.5 million units thrice w...

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:1990-01-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Forns X,Ampurdanès S,Sanchez-Tapias JM,Guilera M,Sans M,Sánchez-Fueyo A,Quintó L,Joya P,Bruguera M,Rodés J

    更新日期:2001-08-01 00:00:00

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    abstract:BACKGROUND/AIMS:The applicability of adult-to-adult living donor liver transplantation has not been established yet. We report the first data in a European center of the process leading to this procedure from the first moment the patients were informed about it. METHODS:In phase 1 of the process, 121 adult patients en...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Rimola A,Llovet JM,Navasa M,Bruix J,Londoño MC,Fuster J,García-Valdecasas JC

    更新日期:2005-07-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Weng X,He Y,Visvabharathy L,Liao CM,Tan X,Balakumar A,Wang CR

    更新日期:2017-10-01 00:00:00

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    abstract::The clinical relevance of a new antimitochondrial antibody, anti-M9, reacting with an outer membrane-associated antigen on liver mitochondria is described. Sera from 22 anti-M2-negative patients with histologically proven primary biliary cirrhosis (PBC) who had been followed for 5-15 years were tested for anti-M9 in t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Klein R,Klöppel G,Fischer R,Fintelmann V,Müting D,Berg PA

    更新日期:1988-06-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Barreca T,Franceschini R,Cataldi A,Rolandi E

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    authors: Moreno C,Berg T,Tanwandee T,Thongsawat S,Van Vlierberghe H,Zeuzem S,Lenz O,Peeters M,Sekar V,De Smedt G

    更新日期:2012-06-01 00:00:00

  • The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

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    pub_type: 杂志文章


    authors: Stienstra R,Mandard S,Tan NS,Wahli W,Trautwein C,Richardson TA,Lichtenauer-Kaligis E,Kersten S,Müller M

    更新日期:2007-05-01 00:00:00

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    abstract:BACKGROUND & AIMS:The primary aim of this study was to compare the rate of global radiofrequency ablation (RFA) failure between monopolar RFA (MonoRFA) vs. no-touch multi-bipolar RFA (NTmbpRFA) for small hepatocellular carcinoma (HCC) ⩽5cm in cirrhotic patients. METHODS:A total of 362 cirrhotic patients were included ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,多中心研究


    authors: Hocquelet A,Aubé C,Rode A,Cartier V,Sutter O,Manichon AF,Boursier J,N'kontchou G,Merle P,Blanc JF,Trillaud H,Seror O

    更新日期:2017-01-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


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    更新日期:2018-03-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Schoemaker MH,Gommans WM,Conde de la Rosa L,Homan M,Klok P,Trautwein C,van Goor H,Poelstra K,Haisma HJ,Jansen PL,Moshage H

    更新日期:2003-08-01 00:00:00

  • Activation of dendritic cells by local ablation of hepatocellular carcinoma.

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ali MY,Grimm CF,Ritter M,Mohr L,Allgaier HP,Weth R,Bocher WO,Endrulat K,Blum HE,Geissler M

    更新日期:2005-11-01 00:00:00

  • The classification and biological functions of the interferons. A review.

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    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Finter NB

    更新日期:1986-01-01 00:00:00

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    abstract:BACKGROUND & AIMS:In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLK...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Majdi A,Aoudjehane L,Ratziu V,Islam T,Afonso MB,Conti F,Mestiri T,Lagouge M,Foufelle F,Ballenghien F,Ledent T,Moldes M,Cadoret A,Fouassier L,Delaunay JL,Aït-Slimane T,Courtois G,Fève B,Scatton O,Prip-Buus C,Rodrig

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    abstract:BACKGROUND & AIMS:The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHOD...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bozic M,Guzmán C,Benet M,Sánchez-Campos S,García-Monzón C,Gari E,Gatius S,Valdivielso JM,Jover R

    更新日期:2016-10-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

    更新日期:1997-02-01 00:00:00