MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitis.

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. METHODS:31 patients with cirrhosis (Child classes A/B/C=8/14/9) received an intr...

journal_title：Journal of hepatology

authors： Brinch K,Møller S,Bendtsen F,Becker U,Henriksen JH

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND/AIMS:Norfloxacin is useful to prevent infections in hospitalized cirrhotic patients with low ascitic fluid protein concentrations. It is also effective in preventing the recurrence of spontaneous bacterial peritonitis. The aim of our study was to determine the efficacy of norfloxacin in the primary prophylax...

journal_title：Journal of hepatology

authors： Grangé JD,Roulot D,Pelletier G,Pariente EA,Denis J,Ink O,Blanc P,Richardet JP,Vinel JP,Delisle F,Fischer D,Flahault A,Amiot X

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND & AIMS:To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C. METHODS:In a multi-center randomized clinical trial in Japan, on patients infected with HCV of genotype 1, 126 patients were assigned to telaprev...

journal_title：Journal of hepatology

authors： Kumada H,Toyota J,Okanoue T,Chayama K,Tsubouchi H,Hayashi N

更新日期：2012-01-01 00:00:00

abstract：:A young female, who had been in excellent health and had used third-generation oral contraceptives, was admitted to hospital because of abdominal pain and ascites. Budd-Chiari syndrome (BCS) was diagnosed by radiographic and histological examination. Tests for myeloproliferative disease, deficiency of coagulation inhi...

journal_title：Journal of hepatology

authors： Minnema MC,Janssen HL,Niermeijer P,de Man RA

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND & AIMS:Lysosomal acid lipase deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. METHODS:Seb...

journal_title：Journal of hepatology

authors： Valayannopoulos V,Malinova V,Honzík T,Balwani M,Breen C,Deegan PB,Enns GM,Jones SA,Kane JP,Stock EO,Tripuraneni R,Eckert S,Schneider E,Hamilton G,Middleton MS,Sirlin C,Kessler B,Bourdon C,Boyadjiev SA,Sharma R,Twe

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIMS:Von Willebrand factor (vWf) is found in high levels in plasma of patients with acute and chronic liver disease. The role of vWf in liver injury and repair is unknown. We studied the effect of liver mass and remodeling on plasma and tissue vWf after partial hepatectomy. METHODS:Rats were sacrificed post...

journal_title：Journal of hepatology

authors： Baruch Y,Neubauer K,Shenkar L,Sabo E,Ritzel A,Wilfling T,Ramadori G

更新日期：2002-10-01 00:00:00

abstract：:All routinely available assays to detect hepatitis C virus (HCV) infection are based on the specific reaction of serum antibodies to corresponding viral antigens. The only method to detect viral nucleic acids in serum or liver is the enzymatic amplification of reversely transcribed HCV-RNA by polymerase chain reaction...

journal_title：Journal of hepatology

authors： Geiger CP,Caselmann WH

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and func...

journal_title：Journal of hepatology

authors： Chen KT,Pernelle K,Tsai YH,Wu YH,Hsieh JY,Liao KH,Guguen-Guillouzo C,Wang HW

更新日期：2014-12-01 00:00:00

abstract：:To evaluate the efficacy of recombinant interferon alpha-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected recombinant interferon alpha-2...

journal_title：Journal of hepatology

authors： Hwang SJ,Lee SD,Chan CY,Lu RH,Lo KJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND/AIMS:Liver allograft is known to protect simultaneously transplanted organs from acute rejection. We have reported that only 6% of combined liver-kidney recipients, versus 32.5% of kidney recipients, develop kidney graft acute rejection. Release of soluble human leukocyte antigen (HLA) molecules by the liver...

journal_title：Journal of hepatology

authors： Créput C,Durrbach A,Menier C,Guettier C,Samuel D,Dausset J,Charpentier B,Carosella ED,Rouas-Freiss N

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND/AIMS:The purpose of this study was to compare the epidemiological, biochemical, virological and histological characteristics of patients with chronic hepatitis B and C with those of patients suffering from chronic hepatitis C alone. METHODS:Twenty-three patients with chronic hepatitis C, who were anti-HCV p...

journal_title：Journal of hepatology

authors： Zarski JP,Bohn B,Bastie A,Pawlotsky JM,Baud M,Bost-Bezeaux F,Tran van Nhieu J,Seigneurin JM,Buffet C,Dhumeaux D

更新日期：1998-01-01 00:00:00

abstract：:Three patients with Budd-Chiari syndrome in association with the 'lupus' anticoagulant are described. This anticoagulant was looked for in our patients with an otherwise idiopathic hepatic venous thrombosis because of the presence of a pronounced thrombocytopenia, a prolonged activated partial thromboplastin time or a...

journal_title：Journal of hepatology

authors： Van Steenbergen W,Beyls J,Vermylen J,Fevery J,Marchal G,Desmet V,De Groote J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cholesterol crystallization in a dilute, bile salt-rich model bile is a multiphase process in which early filamentous crystals gradually transform to classical cholesterol monohydrate plates. The pertinence of similar transformations in more complex model systems or native bile is, however, unclear. The...

journal_title：Journal of hepatology

authors： Konikoff FM,Laufer H,Messer G,Gilat T

更新日期：1997-03-01 00:00:00

abstract：:A monoclonal antibody, designated K-PLC1, has been produced to a tumour-associated antigen on the cell membrane of the PLC/PRF/5 cell line. Using an indirect immunofluorescence technique this antibody produced membrane staining of three hepatocellular carcinoma (HCC) cell lines and it has positively stained 10 of 11 h...

journal_title：Journal of hepatology

authors： Dunk AA,Brown D,Weidmann K,Thomas HC

更新日期：1987-02-01 00:00:00

abstract：:alpha-Interferon therapy normalizes aminotransferase levels in approximately 50% of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after ...

journal_title：Journal of hepatology

authors： Camps J,García-Granero M,Riezu-Boj JI,Larrea E,de Alava E,Civeira MP,Castilla A,Prieto J

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the clinical, biochemical and histological implications of a concomitant HGV infection in "HCV-related" chronic liver disease. METHODS:Eighty-three HCV-RNA positive patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR. RESULTS:Twenty-two (26.5%) patie...

journal_title：Journal of hepatology

authors： Francesconi R,Giostra F,Ballardini G,Manzin A,Solforosi L,Lari F,Descovich C,Ghetti S,Grassi A,Bianchi G,Zauli D,Clementi M,Bianchi FB

更新日期：1997-06-01 00:00:00

abstract：:We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but i...

journal_title：Journal of hepatology

authors： van 't Wout JW,Herrmann WA,de Vries RA,Stricker BH

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND AIMS:In hepatitis C there is controversy over the linearity of the rate of progression and the significance of gender, mode of infection and viral factors. METHODS:2313 untreated patients with a reliable estimated duration of infection and liver fibrosis were included. Fibrosis progression was calculated us...

journal_title：Journal of hepatology

authors： Poynard T,Ratziu V,Charlotte F,Goodman Z,McHutchison J,Albrecht J

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND & AIMS:Treating HCV infection reduces overall mortality and reduces the risk of multiple extrahepatic complications. Whether the reduction in mortality is primarily due to a reduction in liver-related causes or extrahepatic complications is unknown. METHODS:We identified HCV-positive individuals treated for...

journal_title：Journal of hepatology

authors： Butt AA,Yan P,Shaikh OS,Lo Re V 3rd,Abou-Samra AB,Sherman KE

更新日期：2020-08-01 00:00:00

abstract：:In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those...

journal_title：Journal of hepatology

authors： Dhar A,Mullish BH,Thursz MR

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND & AIMS:Patients listed with exception points for hepatocellular carcinoma (HCC) have been more likely to be transplanted than those listed for chronic liver failure (LF) based on the model for end-stage liver disease (MELD) score. The aim of this study was to determine outcomes in the 5-year experience of a ...

journal_title：Journal of hepatology

authors： Bhat M,Ghali P,Dupont B,Hilzenrat R,Tazari M,Roy A,Chaudhury P,Alvarez F,Carrier M,Bilodeau M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND & AIMS:Large extracellular vesicles, specifically AnnexinV+ EpCAM+ CD147+ tumour-associated microparticles (taMPs), facilitate the detection of colorectal carcinoma (CRC), non-small cell lung carcinoma (NSCLC) as well as pancreas carcinoma (PaCa). Here we assess the diagnostic value of taMPs for detection an...

journal_title：Journal of hepatology

authors： Julich-Haertel H,Urban SK,Krawczyk M,Willms A,Jankowski K,Patkowski W,Kruk B,Krasnodębski M,Ligocka J,Schwab R,Richardsen I,Schaaf S,Klein A,Gehlert S,Sänger H,Casper M,Banales JM,Schuppan D,Milkiewicz P,Lammert F,

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND & AIMS:The insignificance of pure microsteatosis (MiS) was reported in living donor liver transplantation (LDLT). However, since steatosis is mostly found in a mixed form of microsteatosis (MiS) and macrosteatosis (MaS), we aimed to determine the importance of MiS mixed with MaS in LDLT. METHODS:Donor match...

journal_title：Journal of hepatology

authors： Han S,Ha SY,Park CK,Joh JW,Kwon CH,Kwon GY,Kim G,Gwak MS,Jeong WK,Ko JS

更新日期：2015-03-01 00:00:00

abstract：:Because of the tremendous success of clinical transplantation of the liver and other organs in the last three decades, the demand for organs for transplantation has risen sharply and there is now a substantial shortage. The utilization of organs from other species, xenotransplantation, is increasingly viewed as a pote...

journal_title：Journal of hepatology

authors： Harland RC,Platt JL

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to identify preoperative magnetic resonance (MR) imaging biomarkers for predicting microvascular invasion (MVI), to determine their diagnostic performance and to evaluate whether they are associated with early recurrence after surgery for single hepatocellular carcinoma (HCC). METHOD...

journal_title：Journal of hepatology

authors： Lee S,Kim SH,Lee JE,Sinn DH,Park CK

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND & AIMS:Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b. METHODS:We analyzed p...

journal_title：Journal of hepatology

authors： Kawaoka T,Hayes CN,Ohishi W,Ochi H,Maekawa T,Abe H,Tsuge M,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Tsunoda T,Nakamura Y,Kumada H,Chayama K

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND/METHODS:In order to define the clinical significance of borderline levels of IgM anti-HBc in chronic hepatitis B patients, we followed up 89 untreated hepatitis B patients (19 HBeAg pos and 70 anti-HBe pos) for 1 year, with monthly monitoring of IgM anti-HBc using a highly sensitive quantitative microparticl...

journal_title：Journal of hepatology

authors： Colloredo G,Bellati G,Leandro G,Colombatto P,Rho A,Bissoli F,Brunetto MR,Angeli G,Ideo G,Bonino F

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIMS:Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior. METHODS:In this study, genome-wide aberrations in 13 cases of cholan...

journal_title：Journal of hepatology

authors： Wong N,Li L,Tsang K,Lai PB,To KF,Johnson PJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HC...

journal_title：Journal of hepatology

authors： Bonnin M,Fares N,Testoni B,Estornes Y,Weber K,Vanbervliet B,Lefrançois L,Garcia A,Kfoury A,Pez F,Coste I,Saintigny P,Viari A,Lang K,Guey B,Hervieu V,Bancel B,Bartoch B,Durantel D,Renno T,Merle P,Lebecque S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatocyte growth factor (HGF) plays an important role as a mitogen in liver regeneration. However, little is known about the metabolic effects of HGF in the liver. Studies were performed to examine whether HGF influences carbohydrate metabolism, which is drastically changed in the early course of the r...

journal_title：Journal of hepatology

authors： Kaibori M,Kwon AH,Teshima S,Nakanishi H,Kitano T,Kamiyama Y,Okumura T

更新日期：2003-04-01 00:00:00