Major histocompatibility complex antigens in human liver transplants.

abstract：BACKGROUND & AIMS:The therapeutic option for patients with chronic hepatitis delta virus infection (CHD) is limited to interferon alpha with rare curative outcome. Myrcludex B is a first-in-class entry inhibitor inactivating the hepatitis B virus (HBV) and hepatitis D virus (HDV) receptor sodium taurocholate co-transpo...

journal_title：Journal of hepatology

authors： Bogomolov P,Alexandrov A,Voronkova N,Macievich M,Kokina K,Petrachenkova M,Lehr T,Lempp FA,Wedemeyer H,Haag M,Schwab M,Haefeli WE,Blank A,Urban S

更新日期：2016-09-01 00:00:00

abstract：:alpha-Interferon therapy normalizes aminotransferase levels in approximately 50% of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after ...

journal_title：Journal of hepatology

authors： Camps J,García-Granero M,Riezu-Boj JI,Larrea E,de Alava E,Civeira MP,Castilla A,Prieto J

更新日期：1994-07-01 00:00:00

abstract：:A young female, who had been in excellent health and had used third-generation oral contraceptives, was admitted to hospital because of abdominal pain and ascites. Budd-Chiari syndrome (BCS) was diagnosed by radiographic and histological examination. Tests for myeloproliferative disease, deficiency of coagulation inhi...

journal_title：Journal of hepatology

authors： Minnema MC,Janssen HL,Niermeijer P,de Man RA

更新日期：2000-09-01 00:00:00

abstract：:Thirty-five consecutive patients with primary biliary cirrhosis were examined using liver biopsy, laboratory tests and ultrasonography of the hepato-duodenal ligament to investigate the possible correlation between enlarged lymph nodes in the hepato-duodenal ligament and biochemical activity, histologic activity or st...

journal_title：Journal of hepatology

authors： Lyttkens K,Prytz H,Forsberg L,Hederström E,Hägerstrand I

更新日期：1992-05-01 00:00:00

abstract：AIM:In order to study the short-term effect of moderate and severe reduction of liver function by acetaminophen poisoning of different severity on gene expression for liver-specific functions, rats were given 3.75 and 7.5 g per kg body weight acetaminophen intragastrically. The lower dose is associated with low mortali...

journal_title：Journal of hepatology

authors： Tygstrup N,Jensen SA,Krog B,Dalhoff K

更新日期：1996-08-01 00:00:00

abstract：AIMS:To assess the presence of autonomic neuropathy in patients with non-alcoholic chronic liver disease and its relationships with the severity of liver damage. METHODS:Thirty non-alcoholic patients with chronic liver disease and 26 healthy control subjects were studied. The silicone imprint technique was used to qua...

journal_title：Journal of hepatology

authors： Oliver MI,Miralles R,Rubíes-Prat J,Navarro X,Espadaler JM,Solá R,Andreu M

更新日期：1997-06-01 00:00:00

abstract：:Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effe...

journal_title：Journal of hepatology

authors： Nagase S,Isobe H,Ayukawa K,Sakai H,Nawata H

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND/AIMS:Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of t...

journal_title：Journal of hepatology

authors： Punia P,Cane P,Teo CG,Saunders N

更新日期：2004-06-01 00:00:00

abstract：:Hepatic fibrosis represents an important stage in the progression of chronic liver disease to cirrhosis. In the present paper we have investigated whether capsaicin-sensitive neuropeptide-containing sensory neurons may participate in the development of liver fibrosis. The expression of hepatic fibrosis induced by comm...

journal_title：Journal of hepatology

authors： Casini A,Lippe IT,Evangelista S,Geppetti P,Santicioli P,Urso C,Paglierani M,Maggi CA,Surrenti C

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND/AIMS:In this study, a detailed morphometrical analysis of the hepatic microvasculature in the different zones of hepatic parenchyma was performed in normal and cirrhotic rat liver (CCl4-induced). The aims were to detect, in CCl4-induced cirrhosis, the real presence of the "capillarization" of hepatic sinusoi...

journal_title：Journal of hepatology

authors： Onori P,Morini S,Franchitto A,Sferra R,Alvaro D,Gaudio E

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND & AIMS:Herpes simplex virus hepatitis is a rare, but severe disease, thus far only documented by case reports and short series. The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis. METHODS:We assesse...

journal_title：Journal of hepatology

authors： Moldovan B,Mentha G,Majno P,Berney T,Morard I,Giostra E,Wildhaber BE,Van Delden C,Morel P,Toso C

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:It is established that cirrhotic patients who respond to beta-blockers by lowering their hepatic venous pressure gradient (HVPG) to < or =12 mmHg or by > or =20% of the baseline values are protected from bleeding. However, it is not known whether the effect remains unchanged over the treatment period....

journal_title：Journal of hepatology

authors： Merkel C,Bolognesi M,Berzigotti A,Amodio P,Cavasin L,Casarotto IM,Zoli M,Gatta A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Liver negative-strand hepatitis C virus (HCV) RNA is the most direct indicator of active viral replication but has only been examined in a few semiquantitative studies. METHODS:Positive- and negative-strand HCV RNA in the right (R) and left (L) liver lobes was quantified by rTth-based strand-specific r...

journal_title：Journal of hepatology

authors： Yuki N,Matsumoto S,Tadokoro K,Mochizuki K,Kato M,Yamaguchi T

更新日期：2006-02-01 00:00:00

abstract：:The clinical relevance of a new antimitochondrial antibody, anti-M9, reacting with an outer membrane-associated antigen on liver mitochondria is described. Sera from 22 anti-M2-negative patients with histologically proven primary biliary cirrhosis (PBC) who had been followed for 5-15 years were tested for anti-M9 in t...

journal_title：Journal of hepatology

authors： Klein R,Klöppel G,Fischer R,Fintelmann V,Müting D,Berg PA

更新日期：1988-06-01 00:00:00

abstract：:Recently reports have indicated that both cimetidine and ranitidine delay cell proliferation in rats following 70% partial hepatectomy and result in an increased mortality following this procedure. The present study was designed to determine whether three H2 blocking agents (cimetidine, ranitidine, famotidine) and a n...

journal_title：Journal of hepatology

authors： Francavilla A,Panella C,Polimeno L,Di Leo A,Makowka L,Barone M,Amoruso A,Ingrosso M,Starzl TE

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND/AIMS:Previously, trichostatin A (TSA), a histone deacetylase inhibitor, has been shown to exhibit strong antifibrotic characteristics in hepatic stellate cells (HSC), which are known to play a central role in chronic liver diseases. TSA retained a more quiescent phenotype in spite of culture conditions that ...

journal_title：Journal of hepatology

authors： Rombouts K,Knittel T,Machesky L,Braet F,Wielant A,Hellemans K,De Bleser P,Gelman I,Ramadori G,Geerts A

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND/AIMS:Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differ...

journal_title：Journal of hepatology

authors： Tsai YH,Kuang WF,Lu TY,Kao JH,Lai MY,Liu CJ,Chen PJ,Hwang LH

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Retrorsine, a naturally occurring pyrrolizidine alkaloid, impairs liver regeneration after partial hepatectomy by mechanisms that are still unclear. AIM:The aim of the study was to clarify the influence of retrorsine on cell cycle progression in the regenerating liver lobes of rats after portal branch ligat...

journal_title：Journal of hepatology

authors： Picard C,Lambotte L,Starkel P,Sempoux C,Saliez A,Van Den Berge V,de Saeger C,Horsmans Y

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND/AIMS:We previously reported that the populations of lymphocytes and the expression of activated antigens in human sinusoidal mononuclear cells were different from those in peripheral blood mononuclear cells. Attempts to culture these cells for further study failed because they died rapidly under standard cul...

journal_title：Journal of hepatology

authors： Kinoshita K,Kanai M,Awane M,Furuke K,Shirakata Y,Gomi T,Nakamura Y,Ikai I,Yamauchi A,Inamoto T,Ohmori K,Yamaoka Y

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms of treatment resistance to interferon (IFN) and ribavirin (Rib) combination therapy for hepatitis C virus (HCV) infection are not known. This study aims to gain insight into these mechanisms by exploring hepatic gene expression before and during treatment. METHODS:Liver biopsy was perf...

journal_title：Journal of hepatology

authors： Honda M,Nakamura M,Tateno M,Sakai A,Shimakami T,Shirasaki T,Yamashita T,Arai K,Yamashita T,Sakai Y,Kaneko S

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/AIMS:A simple and reproducible hepatic immunohistochemical staining (IHS) for hepatitis C virus (HCV) is not available. We aimed to validate hepatic IHS with monoclonal antibody (Mab) IG222, directed against the HCV-envelope 2 (E2) protein. METHODS:A three-step indirect immunoperoxidase method was used for ...

journal_title：Journal of hepatology

authors： Verslype C,Nevens F,Sinelli N,Clarysse C,Pirenne J,Depla E,Maertens G,van Pelt J,Desmet V,Fevery J,Roskams T

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND/AIMS:Many Concanavalin A-binding glycoproteins have been proposed to influence cholesterol crystallization in human bile. This has been studied mainly by addition of the Concanavalin A-binding fraction to model bile. The physiological relevance of the proteins in native bile is not yet known. The aim of this...

journal_title：Journal of hepatology

authors： Keulemans YC,Mok KS,Gouma DJ,Groen AK

更新日期：1997-12-01 00:00:00

abstract：:HCV infection is a global health problem that affects 170 million people worldwide. The severity of the disease varies from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma (HCC). Recently, the standard of care for genotype 1 patients has greatly improved with the addition of protease inhibitor...

journal_title：Journal of hepatology

authors： Estrabaud E,Vidaud M,Marcellin P,Asselah T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:To compare the management and the virological and serological efficacy of treatments for chronic hepatitis B (CHB) in HIV positive and negative patients. METHODS:Two hundred and forty-six HIV positive and 205 HIV negative consecutive patients with past or present CHB, seen in October 2008 in particip...

journal_title：Journal of hepatology

authors： Piroth L,Pol S,Lacombe K,Miailhes P,Rami A,Rey D,Loustau-Ratti V,Morlat P,Goderel I,Sene D,Rosenthal E,Carrat F,Cacoub P,GERMIVIC Study Group.

更新日期：2010-12-01 00:00:00

abstract：:Liver disease is common in patients with cystic fibrosis, but the pathogenesis is poorly understood. The chronic colonization of bacteria in the lower airways leads to repeated treatments with antibiotics, especially aminoglycosides in high dosages. To investigate the possible role of aminoglycoside treatment in the n...

journal_title：Journal of hepatology

authors： Lindblad A,Hultcrantz R,Strandvik B

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND/AIMS:We have developed a gene therapy strategy based on the observation that insulin-like growth factor I (IGF-I) is necessary for the acquisition and maintenance of the transformed phenotype in hepatocarcinoma. This strategy consists in transfecting the rat hepatoma cell line with an episomal vector express...

journal_title：Journal of hepatology

authors： Ellouk-Achard S,Djenabi S,De Oliveira GA,Desauty G,Duc HT,Zohair M,Trojan J,Claude JR,Sarasin A,Lafarge-Frayssinet C

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIMS:The pathophysiology of binge drinking of ethanol and its potentiation of acetaminophen (APAP) toxicity has received very little attention. To evaluate if ethanol binging sensitizes hepatic sinusoidal endothelial cells (SEC) and liver to APAP toxicity. METHODS:The histopathological responses to APAP wer...

journal_title：Journal of hepatology

authors： McCuskey RS,Bethea NW,Wong J,McCuskey MK,Abril ER,Wang X,Ito Y,DeLeve LD

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND & AIMS:miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory region and characterized its transcriptional regulation by the NFκB-dependent inflammatory pathways. METHODS:Mature miRNA expre...

journal_title：Journal of hepatology

authors： Scisciani C,Vossio S,Guerrieri F,Schinzari V,De Iaco R,D'Onorio de Meo P,Cervello M,Montalto G,Pollicino T,Raimondo G,Levrero M,Pediconi N

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND/AIMS:The ability to transfer foreign genes into the biliary tract would be useful for the treatment of biliary tract diseases, including cancer, cystic fibrosis and other genetic diseases. To introduce a foreign gene precisely into the rat biliary epithelial cells, we developed a new technique, inserting a p...

journal_title：Journal of hepatology

authors： Uehara T,Honda K,Hatano E,Terao R,Iimuro Y,Yamamoto N,Yamamoto M,Kaneda Y,Yamaoka Y

更新日期：1999-05-01 00:00:00

abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

journal_title：Journal of hepatology

authors： Romero-Gómez M,Berenguer M,Molina E,Calleja JL

更新日期：2013-12-01 00:00:00