Abstract:
:Hepatic fibrosis represents an important stage in the progression of chronic liver disease to cirrhosis. In the present paper we have investigated whether capsaicin-sensitive neuropeptide-containing sensory neurons may participate in the development of liver fibrosis. The expression of hepatic fibrosis induced by common bile duct obstruction has been studied both in capsaicin- and vehicle-treated rats. Common bile duct-induced liver fibrosis was less marked in capsaicin-treated rats than in vehicle-treated rats. Diffuse alterations of liver parenchyma structure with marked collagen deposition and nodular regeneration occurred 8 weeks after common bile duct ligation in vehicle-treated animals, while none of the capsaicin-treated rats exhibited the formation of complete connective septa altering the parenchyma architecture. Both vehicle- and capsaicin-treated rats showed an increasing number of desmin-positive cells in the perivenular zone, but the density of these cells was lower in treated animals than in untreated rats. The hydroxyproline content of the liver increased after common bile duct ligation in a time-dependent manner. Eight weeks after bile duct obstruction vehicle-treated rats showed a 7-fold increase of liver collagen content in comparison to normal animals. This enhancement was about 3.5-fold in capsaicin-treated rats. These findings raise the possibility that the peripheral release of neuropeptides stored in sensory nerves might participate in the development of liver fibrosis following common bile duct obstruction.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Casini A,Lippe IT,Evangelista S,Geppetti P,Santicioli P,Urso C,Paglierani M,Maggi CA,Surrenti Cdoi
10.1016/0168-8278(90)90212-asubject
Has Abstractpub_date
1990-11-01 00:00:00pages
302-12issue
3eissn
0168-8278issn
1600-0641pii
0168-8278(90)90212-Ajournal_volume
11pub_type
杂志文章abstract:BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...
journal_title:Journal of hepatology
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journal_title:Journal of hepatology
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journal_title:Journal of hepatology
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:1996-12-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2010.09.032
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0168-8278(91)90937-7
更新日期:1991-03-01 00:00:00
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journal_title:Journal of hepatology
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of hepatology
pub_type: 杂志文章,评审
doi:10.1016/j.jhep.2017.11.006
更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00