Effect of sensory denervation with capsaicin on liver fibrosis induced by common bile duct ligation in rat.

Abstract:

:Hepatic fibrosis represents an important stage in the progression of chronic liver disease to cirrhosis. In the present paper we have investigated whether capsaicin-sensitive neuropeptide-containing sensory neurons may participate in the development of liver fibrosis. The expression of hepatic fibrosis induced by common bile duct obstruction has been studied both in capsaicin- and vehicle-treated rats. Common bile duct-induced liver fibrosis was less marked in capsaicin-treated rats than in vehicle-treated rats. Diffuse alterations of liver parenchyma structure with marked collagen deposition and nodular regeneration occurred 8 weeks after common bile duct ligation in vehicle-treated animals, while none of the capsaicin-treated rats exhibited the formation of complete connective septa altering the parenchyma architecture. Both vehicle- and capsaicin-treated rats showed an increasing number of desmin-positive cells in the perivenular zone, but the density of these cells was lower in treated animals than in untreated rats. The hydroxyproline content of the liver increased after common bile duct ligation in a time-dependent manner. Eight weeks after bile duct obstruction vehicle-treated rats showed a 7-fold increase of liver collagen content in comparison to normal animals. This enhancement was about 3.5-fold in capsaicin-treated rats. These findings raise the possibility that the peripheral release of neuropeptides stored in sensory nerves might participate in the development of liver fibrosis following common bile duct obstruction.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Casini A,Lippe IT,Evangelista S,Geppetti P,Santicioli P,Urso C,Paglierani M,Maggi CA,Surrenti C

doi

10.1016/0168-8278(90)90212-a

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

302-12

issue

3

eissn

0168-8278

issn

1600-0641

pii

0168-8278(90)90212-A

journal_volume

11

pub_type

杂志文章
  • Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2012.02.016

    authors: Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

    更新日期:2012-07-01 00:00:00

  • Autonomic dysfunction in patients with non-alcoholic chronic liver disease.

    abstract:AIMS:To assess the presence of autonomic neuropathy in patients with non-alcoholic chronic liver disease and its relationships with the severity of liver damage. METHODS:Thirty non-alcoholic patients with chronic liver disease and 26 healthy control subjects were studied. The silicone imprint technique was used to qua...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(97)80458-8

    authors: Oliver MI,Miralles R,Rubíes-Prat J,Navarro X,Espadaler JM,Solá R,Andreu M

    更新日期:1997-06-01 00:00:00

  • The relationship of endoscopy, portal Doppler ultrasound flowmetry, and clinical and biochemical tests in cirrhosis.

    abstract::The relationship of the endoscopic aspect of esophageal varices, portal quantitative Doppler ultrasound parameters and clinical and biochemical findings was assessed in 149 patients with cirrhosis stratified according to the presence of esophageal varices (n = 115) and the absence of previous bleeding (n = 96). In thi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(05)80461-1

    authors: Siringo S,Bolondi L,Gaiani S,Sofia S,Di Febo G,Zironi G,Rigamonti A,Miglioli M,Cavalli G,Barbara L

    更新日期:1994-01-01 00:00:00

  • Insulin resistance undermines the advantages of IL28B polymorphism in the pegylated interferon alpha-2b and ribavirin treatment of chronic hepatitis C patients with genotype 1.

    abstract:BACKGROUND & AIMS:Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of In...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2012.04.027

    authors: Ogawa E,Furusyo N,Murata M,Ikezaki H,Ihara T,Hayashi T,Toyoda K,Taniai H,Okada K,Kainuma M,Hayashi J

    更新日期:2012-09-01 00:00:00

  • Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.

    abstract:BACKGROUND & AIMS:Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown how the host cell senses HDV and if this defense affects HDV replication. We aim to characterize interferon (IFN) activation by HDV, identify ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2018.02.021

    authors: Zhang Z,Filzmayer C,Ni Y,Sültmann H,Mutz P,Hiet MS,Vondran FWR,Bartenschlager R,Urban S

    更新日期:2018-07-01 00:00:00

  • Dendritic cell maturation in HCV infection: altered regulation of MHC class I antigen processing-presenting machinery.

    abstract:BACKGROUND & AIMS:Modulation of dendritic cell (DC) function has been theorized as one of the mechanisms used by hepatitis C virus (HCV) to evade the host immune response and cause persistent infection. METHODS:We used a range of cell and molecular biology techniques to study DC subsets from uninfected and HCV-infecte...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2014.04.007

    authors: Leone P,Di Tacchio M,Berardi S,Santantonio T,Fasano M,Ferrone S,Vacca A,Dammacco F,Racanelli V

    更新日期:2014-08-01 00:00:00

  • Long-term follow-up of chronic hepatitis C in patients diagnosed at a tertiary-care center.

    abstract:BACKGROUND/AIMS:The natural history of chronic hepatitis C (HCV) is not completely understood. This study was aimed to evaluate the long-term outcome of the disease over a prolonged period of time and to identify factors associated with progression. METHODS:One hundred and sixteen patients with non-cirrhotic chronic n...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(01)00088-5

    authors: Forns X,Ampurdanès S,Sanchez-Tapias JM,Guilera M,Sans M,Sánchez-Fueyo A,Quintó L,Joya P,Bruguera M,Rodés J

    更新日期:2001-08-01 00:00:00

  • 'Lupus' anticoagulant and thrombosis of the hepatic veins (Budd-Chiari syndrome). Report of three patients and review of the literature.

    abstract::Three patients with Budd-Chiari syndrome in association with the 'lupus' anticoagulant are described. This anticoagulant was looked for in our patients with an otherwise idiopathic hepatic venous thrombosis because of the presence of a pronounced thrombocytopenia, a prolonged activated partial thromboplastin time or a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(86)80151-9

    authors: Van Steenbergen W,Beyls J,Vermylen J,Fevery J,Marchal G,Desmet V,De Groote J

    更新日期:1986-01-01 00:00:00

  • Involvement of LFA-1 in hepatic NK cell (pit cell)-mediated cytolysis and apoptosis of colon carcinoma cells.

    abstract:BACKGROUND/AIMS:Previous studies have shown that hepatic natural killer (NK) cells, also called pit cells, have a higher cytotoxicity against certain tumor cells and have a higher expression of the cell adhesion molecule CD11a as compared with blood NK cells. We further investigated the involvement of the adhesion mole...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(99)80170-6

    authors: Luo D,Vermijlen D,Vanderkerken K,Kuppen PJ,Seynaeve C,Eddouks M,Baekeland M,Wisse E

    更新日期:1999-07-01 00:00:00

  • Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver.

    abstract::Ursodeoxycholate has been advocated for the treatment of cholestatic liver diseases. The coinfusion of tauroursodeoxycholate with taurolithocholate in the perfused rat liver completely prevented the decrease of bile flow and the increase of oxygen uptake found with taurolithocholate only. Bile flow and bile salt secre...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/0168-8278(90)90133-c

    authors: Schölmerich J,Baumgartner U,Miyai K,Gerok W

    更新日期:1990-05-01 00:00:00

  • Pulmonary contraindications, indications and MELD exceptions for liver transplantation: a contemporary view and look forward.

    abstract::Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2013.03.026

    authors: Krowka MJ,Wiesner RH,Heimbach JK

    更新日期:2013-08-01 00:00:00

  • GBV-C/HGV is not the major cause of autoimmune hepatitis.

    abstract::Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(96)80306-0

    authors: Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

    更新日期:1996-12-01 00:00:00

  • Hepatitis C infection and autoimmunity.

    abstract::Since the first tests for antibodies to components of the hepatitis C virus became widely available there has been considerable interest in evidence linking HCV infection with autoimmune liver diseases and other autoimmune conditions. With respect to autoimmune hepatitis, it is now clear that the early tests were quit...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Eddleston AL

    更新日期:1996-01-01 00:00:00

  • Antitumor effect of the nucleoside analogs 2-chlorodeoxyadenosine and 2',2'-difluorodeoxycytidine on human hepatoma HepG2 cells.

    abstract:BACKGROUND/AIMS:Hepatocellular carcinoma is one of the most malignant tumors in the world. Although a wide range of therapeutic options is available, the efficacy of these methods and the prognosis of hepatocellular carcinoma are still very poor. The nucleoside analogs 2-chlorodeoxyadenosine (Cladribine, 2-CdA) and 2',...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(98)80326-7

    authors: Graziadei I,Kelly T,Schirmer M,Geisen FH,Vogel W,Konwalinka G

    更新日期:1998-03-01 00:00:00

  • Inositol phosphate responses in portal veins from portal hypertensive rats: receptor- and nonreceptor-mediated responses.

    abstract:BACKGROUND/AIMS:Venous hyporesponsiveness in portal hypertension has been reported previously by us. The present study was undertaken to investigate possible changes of phosphoinositide signal transduction pathway in the portal veins from portal hypertensive rats METHODS:Portal hypertension was induced by partial port...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(97)80055-4

    authors: Huang YT,Chang SP,Lin HC,Yang MC,Hong CY

    更新日期:1997-02-01 00:00:00

  • A comparison of fibrosis progression in chronic liver diseases.

    abstract:BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(02)00413-0

    authors: Poynard T,Mathurin P,Lai CL,Guyader D,Poupon R,Tainturier MH,Myers RP,Muntenau M,Ratziu V,Manns M,Vogel A,Capron F,Chedid A,Bedossa P,PANFIBROSIS Group.

    更新日期:2003-03-01 00:00:00

  • Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.

    abstract:BACKGROUND & AIMS:Glucagon-like peptide-1 (GLP-1), a gut-derived peptide degraded by dipeptidyl peptidase-4 (DPP4), stimulates insulin secretion in response to nutrients, yet its direct effect on the liver is controversial. We investigated the effects of GLP-1 on hepatic fat and glucose metabolism and elucidated its me...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2010.09.032

    authors: Ben-Shlomo S,Zvibel I,Shnell M,Shlomai A,Chepurko E,Halpern Z,Barzilai N,Oren R,Fishman S

    更新日期:2011-06-01 00:00:00

  • Expression of HLA antigens and T cell infiltrates in chronic viral hepatitis. A comparison of biopsy and fine-needle aspiration findings.

    abstract::To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/0168-8278(91)90937-7

    authors: Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

    更新日期:1991-03-01 00:00:00

  • Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.

    abstract::Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiation codon and three am...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/0168-8278(91)90036-b

    authors: Fernholz D,Stemler M,Brunetto M,Bonino F,Will H

    更新日期:1991-01-01 00:00:00

  • Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view.

    abstract::Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2020.07.014

    authors: Thietart S,Rautou PE

    更新日期:2020-12-01 00:00:00

  • Applicability of adult-to-adult living donor liver transplantation.

    abstract:BACKGROUND/AIMS:The applicability of adult-to-adult living donor liver transplantation has not been established yet. We report the first data in a European center of the process leading to this procedure from the first moment the patients were informed about it. METHODS:In phase 1 of the process, 121 adult patients en...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2005.02.016

    authors: Rimola A,Llovet JM,Navasa M,Bruix J,Londoño MC,Fuster J,García-Valdecasas JC

    更新日期:2005-07-01 00:00:00

  • Treatment of concanavalin A-induced hepatitis in mice with low molecular weight heparin.

    abstract:BACKGROUND/AIMS:Heparin has been noted to inhibit inflammation independent of its known anti-coagulant activity. In the present study, we examined the ability of heparin and low molecular weight heparin to prevent immune-mediated, concanavalin A-induced liver damage. METHODS:Mice were pretreated with either heparin or...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(99)80284-0

    authors: Hershkoviz R,Bruck R,Aeed H,Shirin H,Halpern Z

    更新日期:1999-11-01 00:00:00

  • Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure.

    abstract:BACKGROUND & AIMS:Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Herein, we assess whether inhibiting TLR4 signaling can ameliorate liver failure and serve as a potential treatment. METHODS:Circulating TLR4 ligands a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.01.011

    authors: Engelmann C,Sheikh M,Sharma S,Kondo T,Loeffler-Wirth H,Zheng YB,Novelli S,Hall A,Kerbert AJC,Macnaughtan J,Mookerjee R,Habtesion A,Davies N,Ali T,Gupta S,Andreola F,Jalan R

    更新日期:2020-07-01 00:00:00

  • Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associa...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2009.12.025

    authors: Ji J,Zhao L,Budhu A,Forgues M,Jia HL,Qin LX,Ye QH,Yu J,Shi X,Tang ZY,Wang XW

    更新日期:2010-05-01 00:00:00

  • Elevated levels of serum carbohydrate deficient transferrin are not specific for alcohol abuse in patients with liver disease.

    abstract:BACKGROUND:Serum carbohydrate deficient transferrin is a marker of chronic alcohol consumption; it increases above normal in healthy individuals after a daily alcohol intake of more than 60 g/d for more than 2 weeks. The influence of liver disease itself on carbohydrate deficient transferrin levels has not been suffici...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/0168-8278(95)80037-9

    authors: Radosavljevic M,Temsch E,Hammer J,Pfeffel F,Mayer G,Renner F,Pidlich J,Muller C

    更新日期:1995-12-01 00:00:00

  • Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2.

    abstract::Interleukin-6 has a variety of biological effects, mainly on the immune system. The regulation of this signal at both the site of production and the site of action is necessary to maintain the organism's homeostasis. In the microenvironment of the hepatic sinusoids, Kupffer cells as resident macrophages are the most p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(94)80099-5

    authors: Hoffmann R,Henninger HP,Schulze-Specking A,Decker K

    更新日期:1994-10-01 00:00:00

  • The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis.

    abstract:BACKGROUND/AIMS:Chronic liver disease is a well-recognised complication of cystic fibrosis. Recent reports suggest that its development is not determined by specific mutations within the cystic fibrosis gene; however, familial clustering of portal hypertension cases and inappropriate immune responses against liver memb...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/0168-8278(95)80058-1

    authors: Duthie A,Doherty DG,Donaldson PT,Scott-Jupp R,Tanner MS,Eddleston AL,Mowat AP

    更新日期:1995-11-01 00:00:00

  • Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing.

    abstract:BACKGROUND/AIMS:The aim of our study was to evaluate the proportion of patients with severe alcoholic cirrhosis who would need orthotopic liver transplantation (OLT) and to determine the optimal delay to evaluate an abstinent patient for transplantation. METHODS:Survival without OLT, improvement in liver function and ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(01)00228-8

    authors: Veldt BJ,Lainé F,Guillygomarc'h A,Lauvin L,Boudjema K,Messner M,Brissot P,Deugnier Y,Moirand R

    更新日期:2002-01-01 00:00:00

  • The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease.

    abstract::Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic incre...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2017.11.006

    authors: Boyle M,Masson S,Anstee QM

    更新日期:2018-02-01 00:00:00

  • Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease.

    abstract:BACKGROUND/AIMS:The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. METHODS:31 patients with cirrhosis (Child classes A/B/C=8/14/9) received an intr...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/s0168-8278(03)00160-0

    authors: Brinch K,Møller S,Bendtsen F,Becker U,Henriksen JH

    更新日期:2003-07-01 00:00:00