High doses of aminoglycosides did not produce liver toxicity in patients with cystic fibrosis.


:Liver disease is common in patients with cystic fibrosis, but the pathogenesis is poorly understood. The chronic colonization of bacteria in the lower airways leads to repeated treatments with antibiotics, especially aminoglycosides in high dosages. To investigate the possible role of aminoglycoside treatment in the natural history of liver disease in cystic fibrosis, five patients were studied for 3 years. Four of the patients received repeated courses of antibiotics, in two of the patients at the time of the liver biopsies. One patient did not receive any aminoglycosides. Light and electron microscopical morphometry was done on liver biopsy specimens. The contents of fat and lysosomes were quantified and expressed as volume density of liver cell volume (%). The amount of fat calculated in this way (13-35%) was highest in one patient who had not received any aminoglycosides. The two patients being treated with aminoglycosides at the time of the biopsy showed small amounts of fat in their liver cells (0.2-1.5%); similar values were noted in some patients who had not been treated for years. The lysosomes did not show the specific changes previously reported to occur in the kidney, nor did the morphometrical quantitation reveal any abnormalities which could be related to the administration of aminoglycosides. The present study did not find liver toxicity related to aminoglycosides in repeated high therapeutic dosages given to patients with cystic fibrosis.


J Hepatol


Journal of hepatology


Lindblad A,Hultcrantz R,Strandvik B




Has Abstract


1994-02-01 00:00:00














  • Different turnover rate of hepatitis C virus clearance by different treatment regimen using interferon-beta.

    abstract:BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

    更新日期:2000-08-01 00:00:00

  • Characterisation of citrate and iron citrate uptake by cultured rat hepatocytes.

    abstract:BACKGROUND/AIMS:The endogenous low molecular weight iron chelator, citrate, is considered to be an important contributor to iron transport and the liver the main site of uptake of iron citrate in subjects suffering from diseases of iron overload. Moreover, the citrate-metabolising enzyme, aconitase, is implicated in th...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Graham RM,Morgan EH,Baker E

    更新日期:1998-10-01 00:00:00

  • Characteristics of patients with dual infection by hepatitis B and C viruses.

    abstract:BACKGROUND/AIMS:The purpose of this study was to compare the epidemiological, biochemical, virological and histological characteristics of patients with chronic hepatitis B and C with those of patients suffering from chronic hepatitis C alone. METHODS:Twenty-three patients with chronic hepatitis C, who were anti-HCV p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zarski JP,Bohn B,Bastie A,Pawlotsky JM,Baud M,Bost-Bezeaux F,Tran van Nhieu J,Seigneurin JM,Buffet C,Dhumeaux D

    更新日期:1998-01-01 00:00:00

  • Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.

    abstract:BACKGROUND & AIMS:To evaluate the hypothesis that increasing T cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a programmed death receptor 1 (PD-1) inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally suppressed patients with HBV e ant...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Gane E,Verdon DJ,Brooks AE,Gaggar A,Nguyen AH,Subramanian GM,Schwabe C,Dunbar PR

    更新日期:2019-11-01 00:00:00

  • HIV infection increases HCV-induced hepatocyte apoptosis.

    abstract:BACKGROUND & AIMS:HCV related liver disease is one of the most important complications in persons with HIV, with accelerated fibrosis progression in coinfected persons compared to those with HCV alone. We hypothesized that HCV-HIV coinfection increases HCV related hepatocyte apoptosis and that HCV and HIV influence TRA...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Jang JY,Shao RX,Lin W,Weinberg E,Chung WJ,Tsai WL,Zhao H,Goto K,Zhang L,Mendez-Navarro J,Jilg N,Peng LF,Brockman MA,Chung RT

    更新日期:2011-04-01 00:00:00

  • Agreement between reported use of interventions for liver diseases and research evidence in Cochrane systematic reviews.

    abstract:BACKGROUND/AIMS:This study evaluates the agreement between reported use of interventions for patients with liver diseases and research evidence in Cochrane systematic reviews. METHODS:In July 2002, the Cochrane Hepato-Biliary Group had completed 28 systematic reviews on 36 interventions that were available in Denmark....

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kürstein P,Gluud LL,Willemann M,Olsen KR,Kjellberg J,Sogaard J,Gluud C

    更新日期:2005-12-01 00:00:00

  • Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is affected by epigenetic factors as well as by genetic variation. METHODS:We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions o...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kitamoto T,Kitamoto A,Ogawa Y,Honda Y,Imajo K,Saito S,Yoneda M,Nakamura T,Nakajima A,Hotta K

    更新日期:2015-08-01 00:00:00

  • Treatment of alcohol use disorders in patients with alcoholic liver disease.

    abstract::Alcohol use disorders (AUDs) is one of the leading causes of disease and disability in almost all European countries. Among the alcohol-related diseases, alcoholic liver disease (ALD) is the most common. At present, alcohol is the most frequent cause of liver cirrhosis in the Western world. The cornerstone of treatmen...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Addolorato G,Mirijello A,Barrio P,Gual A

    更新日期:2016-09-01 00:00:00

  • Suramin inhibits duck hepatitis B virus DNA polymerase activity.

    abstract::Suramin, a polybasic anion, blocks the activity of the DNA polymerase encoded by the duck hepatitis B virus. The interaction with the virus was studied under conditions in which the property of the drug to bind with proteins was used with plasma obtained from infected ducks with viraemia. Inhibition of DNA polymerase ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Tsiquaye K,Zuckerman A

    更新日期:1985-01-01 00:00:00

  • Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.

    abstract:BACKGROUND & AIMS:Glucagon-like peptide-1 (GLP-1), a gut-derived peptide degraded by dipeptidyl peptidase-4 (DPP4), stimulates insulin secretion in response to nutrients, yet its direct effect on the liver is controversial. We investigated the effects of GLP-1 on hepatic fat and glucose metabolism and elucidated its me...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ben-Shlomo S,Zvibel I,Shnell M,Shlomai A,Chepurko E,Halpern Z,Barzilai N,Oren R,Fishman S

    更新日期:2011-06-01 00:00:00

  • Fulminant hepatitis due to Epstein-Barr virus infection.

    abstract::Epstein-Barr virus infection is a benign disease, which may occasionally be fatal, particularly in children. Epstein-Barr virus infection is rare in elderly subjects and appears to have a self-limited course. An unusual case of fulminant hepatitis due to primary Epstein-Barr virus infection in a 62-year-old male 18 da...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Papatheodoridis GV,Delladetsima JK,Kavallierou L,Kapranos N,Tassopoulos NC

    更新日期:1995-09-01 00:00:00

  • New target region of allelic loss in hepatocellular carcinomas within a 1-cM interval on chromosome 6q23.

    abstract:BACKGROUND/AIMS:Frequent allelic losses on the long arm of chromosome 16 in several types of human cancers have suggested that 16q harbors one or more genes that are important for suppressing tumorigenesis in the tissues in question. METHODS:To identify the locations of putative tumor suppressor genes involved in hepa...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Koyama M,Nagai H,Bando K,Matsumoto S,Tajiri T,Onda M,Ito M,Moriyama Y,Emi M

    更新日期:2000-07-01 00:00:00

  • The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease.

    abstract::Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic incre...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Boyle M,Masson S,Anstee QM

    更新日期:2018-02-01 00:00:00

  • Isolation, characterization and biological significance of hepatitis B virus mutants from serum of a patient with immunologically negative HBV infection.

    abstract:BACKGROUND/AIM:A low-titered hepatitis B virus infection without immunological markers was identified in a prospective study in the serum of a kidney transplant recipient by PCR. The aim of this study was to analyze HBV genomes and their biological significance. METHODS:The genome was amplified in two overlapping frag...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Schories M,Peters T,Rasenack J

    更新日期:2000-11-01 00:00:00

  • Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.

    abstract:BACKGROUND/AIMS:Interaction between CYP2E1, ethanol metabolites, and enhanced lipid peroxidation is linked to the pathogenesis of alcoholic liver disease. This study was conducted to compare the expression of various cytochrome enzymes and the appearance of aldehyde adducts in humans. METHODS:Acetaldehyde- and lipid p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Niemelä O,Parkkila S,Juvonen RO,Viitala K,Gelboin HV,Pasanen M

    更新日期:2000-12-01 00:00:00

  • Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.

    abstract:BACKGROUND & AIMS:Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear and compounded by compariso...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Baxter M,Withey S,Harrison S,Segeritz CP,Zhang F,Atkinson-Dell R,Rowe C,Gerrard DT,Sison-Young R,Jenkins R,Henry J,Berry AA,Mohamet L,Best M,Fenwick SW,Malik H,Kitteringham NR,Goldring CE,Piper Hanley K,Vallier L,

    更新日期:2015-03-01 00:00:00

  • Type A, but not type B, endothelin receptor antagonists significantly decrease portal pressure in portal hypertensive rats.

    abstract:BACKGROUND/AIM:Endothelin-1 plays an important role in the regulation of portal hypertension; endothelin antagonists have been extensively studied in portal hypertensive animals. We aimed to evaluate the efficacy of highly selective endothelin antagonists in partial portal vein ligated (PPVL) rats. METHODS:Four groups...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: De Gottardi A,Shaw S,Sägesser H,Reichen J

    更新日期:2000-11-01 00:00:00

  • Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice.

    abstract:BACKGROUND & AIMS:Receptor mediated cell death through the activation of caspases has been identified as an important mechanism to control life and death in various tissues and is thus crucial for the maintenance of liver tissue homeostasis. Here we investigated how caspase 8 (Casp8) differentially regulates immune-med...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Chaudhary K,Liedtke C,Wertenbruch S,Trautwein C,Streetz KL

    更新日期:2013-12-01 00:00:00

  • Analysis of the cost of population screening for haemochromatosis using biochemical and genetic markers.

    abstract:AIMS:To estimate the cost of population screening for haemochromatosis in Australia and to compare the cost of alternative screening strategies. METHODS:The costs of screening for haemochromatosis were analysed in a hypothetical study using transferrin saturation as the primary screening test, with confirmation of the...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bassett ML,Leggett BA,Halliday JW,Webb S,Powell LW

    更新日期:1997-09-01 00:00:00

  • Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

    abstract:BACKGROUND & AIMS:Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b. METHODS:We analyzed p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kawaoka T,Hayes CN,Ohishi W,Ochi H,Maekawa T,Abe H,Tsuge M,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Tsunoda T,Nakamura Y,Kumada H,Chayama K

    更新日期:2011-03-01 00:00:00

  • Non-hypervascular hypointense nodules detected by Gd-EOB-DTPA-enhanced MRI are a risk factor for recurrence of HCC after hepatectomy.

    abstract:BACKGROUND & AIMS:The gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) often depicts non-hypervascular hypointense hepatic nodules during the hepatobiliary phase in patients with hepatocellular carcinoma (HCC). It is unclear whether the presence of thes...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Toyoda H,Kumada T,Tada T,Niinomi T,Ito T,Sone Y,Kaneoka Y,Maeda A

    更新日期:2013-06-01 00:00:00

  • Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study.

    abstract:BACKGROUND/AIMS:Treatment of hepatorenal syndrome (HRS) is based on vasoconstrictors. Terlipressin is the one with the soundest evidence. Noradrenalin has been suggested as an effective alternative. The current study was aimed at assessing the efficacy and safety of noradrenalin vs terlipressin in patients with HRS. M...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Alessandria C,Ottobrelli A,Debernardi-Venon W,Todros L,Cerenzia MT,Martini S,Balzola F,Morgando A,Rizzetto M,Marzano A

    更新日期:2007-10-01 00:00:00

  • Portal vein thrombosis as complication of romiplostim treatment in a cirrhotic patient with hepatitis C-associated immune thrombocytopenic purpura.

    abstract:BACKGROUND & AIMS:Thrombopoietin receptor agonists are a new class of compounds licenced for the treatment of immune thrombocytopenic purpura. They are currently being studied for patients with thrombopenia in advanced liver disease or under therapy for hepatitis C. There are indications that the risk for development o...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Dultz G,Kronenberger B,Azizi A,Mihm U,Vogl TJ,Sarrazin U,Sarrazin C,Zeuzem S,Hofmann WP

    更新日期:2011-07-01 00:00:00

  • Pulmonary contraindications, indications and MELD exceptions for liver transplantation: a contemporary view and look forward.

    abstract::Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Krowka MJ,Wiesner RH,Heimbach JK

    更新日期:2013-08-01 00:00:00

  • Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered.

    abstract:BACKGROUND/AIMS:Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, th...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: McPherson S,Jonsson JR,Cowin GJ,O'Rourke P,Clouston AD,Volp A,Horsfall L,Jothimani D,Fawcett J,Galloway GJ,Benson M,Powell EE

    更新日期:2009-08-01 00:00:00

  • Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis.

    abstract:BACKGROUND/AIMS:Leptin has a particular profibrogenic role in the liver. We investigated whether IFN-alpha influences leptin production in patients with chronic hepatitis B (CHB) and C (CHC). Leptin was determined in serial samples from 63 CHB and 42 CHC IFN-alpha treated patients. Furthermore, we evaluated whether lep...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zografos TA,Rigopoulou EI,Liaskos C,Togousidis E,Zachou K,Gatselis N,Germenis A,Dalekos GN

    更新日期:2006-05-01 00:00:00

  • Accumulation of hydroxyethyl starch (HES) in the liver of patients with renal failure and portal hypertension.

    abstract::Hydroxyethyl starch (HES) has gained wide clinical acceptance as a colloidal plasma substitute. We were able to study the liver biopsies of two patients with renal failure who developed ascites after repeated infusions of HES. All types of liver cells displayed massive accumulation of HES with the morphologic resembla...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Dienes HP,Gerharz CD,Wagner R,Weber M,John HD

    更新日期:1986-01-01 00:00:00

  • Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α.

    abstract:BACKGROUND & AIMS:Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and func...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Chen KT,Pernelle K,Tsai YH,Wu YH,Hsieh JY,Liao KH,Guguen-Guillouzo C,Wang HW

    更新日期:2014-12-01 00:00:00

  • Improvement of ischemic cholangiopathy in three patients with hereditary hemorrhagic telangiectasia following treatment with bevacizumab.

    abstract::The ischemic biliary phenotype of hereditary hemorrhagic telangiectasia (HHT) is rare but distinct, with progressive biliary tree ischemia usually resulting in an irreversible secondary sclerosing cholangiopathy. When clinically severe, liver transplant is often indicated. We report three patients with marked HHT asso...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Vlachou PA,Colak E,Koculym A,Kirpalani A,Kim TK,Hirschfield GM,Faughnan ME

    更新日期:2013-07-01 00:00:00

  • Ion transport in hepatocytes: mechanisms and correlations to cell volume, hormone actions and metabolism.

    abstract::Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Graf J,Häussinger D

    更新日期:1996-01-01 00:00:00