Ultrasound, hepatic lymph nodes and primary biliary cirrhosis.

abstract：BACKGROUND/AIMS:5-Aminolevulinic acid (ALA), a precursor of porphyrins is used for photodynamic diagnosis and therapy within topical or systemic applications. A potential toxic effect on the human liver is of major interest and therefore we investigated the impact of a repeated application of ALA without illumination o...

journal_title：Journal of hepatology

authors： Weiss TS,Pahernik S,Scheruebl I,Jauch KW,Thasler WE

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

journal_title：Journal of hepatology

authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND/AIMS:Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder characterized by reduced plasma levels of low-density lipoproteins. It can be caused by mutations in the gene encoding apolipoprotein B-100 (apo B), leading to the formation of truncated apo Bs which have a reduced capacity to export lipi...

journal_title：Journal of hepatology

authors： Tarugi P,Lonardo A,Ballarini G,Erspamer L,Tondelli E,Bertolini S,Calandra S

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIMS:The liver is the major source of collagen XVIII (C18), the precursor of the angiogenesis inhibitor endostatin. In human liver C18 is mainly expressed by hepatocytes. However, its quantitative and temporospatial expression patterns during liver fibrogenesis are unknown. METHODS:We used RNA quantificatio...

journal_title：Journal of hepatology

authors： Jia JD,Bauer M,Sedlaczek N,Herbst H,Ruehl M,Hahn EG,Riecken EO,Schuppan D

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND/AIMS:The etiopathogenesis of bile duct lesion in primary biliary cirrhosis is unknown, though the participation of bacteria and/or their components and products is suspected. In this study, we tried to detect and identify bacteria in the bile of patients with primary biliary cirrhosis by polymerase chain rea...

journal_title：Journal of hepatology

authors： Hiramatsu K,Harada K,Tsuneyama K,Sasaki M,Fujita S,Hashimoto T,Kaneko S,Kobayashi K,Nakanuma Y

更新日期：2000-07-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：:Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause. The findings are described in detail in...

journal_title：Journal of hepatology

authors： McCaul TF,Fagan EA,Tovey G,Portmann B,Williams R,Zuckerman AJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating...

journal_title：Journal of hepatology

authors： Stienstra R,Mandard S,Tan NS,Wahli W,Trautwein C,Richardson TA,Lichtenauer-Kaligis E,Kersten S,Müller M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into t...

journal_title：Journal of hepatology

authors： Bianco C,Jamialahmadi O,Pelusi S,Baselli G,Dongiovanni P,Zanoni I,Santoro L,Maier S,Liguori A,Meroni M,Borroni V,D'Ambrosio R,Spagnuolo R,Alisi A,Federico A,Bugianesi E,Petta S,Miele L,Vespasiani-Gentilucci U,Anstee

更新日期：2020-11-25 00:00:00

abstract：:Twenty patients with paracetamol(acetaminophen)-induced acute liver damage of varying severity were studied longitudinally with assessment of clinical state, standard liver function tests and radiometric hyaluronate (HYA) assay (Pharmacia). In patients (n = 6) who developed coma, HYA rose rapidly with clinical deterio...

journal_title：Journal of hepatology

authors： Bramley PN,Rathbone BJ,Forbes MA,Cooper EH,Losowsky MS

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver. ME...

journal_title：Journal of hepatology

authors： Moriya A,Iwasaki Y,Ohguchi S,Kayashima E,Mitsumune T,Taniguchi H,Ando M,Yamamoto K

更新日期：2015-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most prevalent human malignancies worldwide with rising incidence in industrialised countries, few therapeutic options and poor prognosis. To expand and improve therapeutic strategies, identification of drug targets involved in several liver cancer-related pathways is crucia...

journal_title：Journal of hepatology

authors： Beck M,Schirmacher P,Singer S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIMS:Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differ...

journal_title：Journal of hepatology

authors： Tsai YH,Kuang WF,Lu TY,Kao JH,Lai MY,Liu CJ,Chen PJ,Hwang LH

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND & AIMS:To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C. METHODS:HIV/HCV co-infected study participants (n=179) were recruited into a prospective cohort and underwent dual-energy X-ray absorptiometry (DXA) within 1 year of a liver...

journal_title：Journal of hepatology

authors： El-Maouche D,Mehta SH,Sutcliffe C,Higgins Y,Torbenson MS,Moore RD,Thomas DL,Sulkowski MS,Brown TT

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:During chronic HCV infection, T cell dependent virus-specific antibodies are produced. However, the role of B-T cell interaction in chronic HCV is largely unknown. CD4(+)CXCR5(+) T follicular helper (TFH)-cells activate B cells and are important for clearance of various chronic viral infections. We in...

journal_title：Journal of hepatology

authors： Spaan M,Kreefft K,de Graav GN,Brouwer WP,de Knegt RJ,ten Kate FJ,Baan CC,Vanwolleghem T,Janssen HL,Boonstra A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/AIMS:To compare carotid intima-media thickness (IMT) - an index of early atherosclerosis - among patients with non-alcoholic steatohepatitis (NASH), patients with chronic hepatitis B (HBV) or C (HCV) and control subjects. METHODS:We studied 60 consecutive patients with biopsy-proven NASH, 60 patients with H...

journal_title：Journal of hepatology

authors： Targher G,Bertolini L,Padovani R,Rodella S,Arcaro G,Day C

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND & AIMS:We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin in established tumours had a therapeutic effect. METHODS:We used lenti...

journal_title：Journal of hepatology

authors： Ménard L,Taras D,Grigoletto A,Haurie V,Nicou A,Dugot-Senant N,Costet P,Rousseau B,Rosenbaum J

更新日期：2010-05-01 00:00:00

abstract：:Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

journal_title：Journal of hepatology

authors： Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

更新日期：1996-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is associated with tremendous morbidity and mortality due to liver complications. HCV infection is also associated with many extrahepatic manifestations including cardiovascular diseases, glucose metabolism impairment, cryoglobulinemia vasculitis, B cell non-Hodgkin lymphoma and chron...

journal_title：Journal of hepatology

authors： Cacoub P,Desbois AC,Isnard-Bagnis C,Rocatello D,Ferri C

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is a common cancer worldwide and remains a major clinical challenge. Ketoconazole, a traditional antifungal agent, has attracted considerable attention as a therapeutic option for cancer treatment. However, its mechanism of action is still not clearly defined. We aimed t...

journal_title：Journal of hepatology

authors： Chen Y,Chen HN,Wang K,Zhang L,Huang Z,Liu J,Zhang Z,Luo M,Lei Y,Peng Y,Zhou ZG,Wei Y,Huang C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis B virus (HBV) infection in extrahepatic tissues is controversial. To clarify whether episomal HBV can infect nonhepatic tissues, we investigated the molecular forms of HBV in the lymphatic cells of inactive HBV carriers who lacked viremia, thus avoiding contamination with HBV genomes originati...

journal_title：Journal of hepatology

authors： Umeda M,Marusawa H,Seno H,Katsurada A,Nabeshima M,Egawa H,Uemoto S,Inomata Y,Tanaka K,Chiba T

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND & AIMS:The therapeutic option for patients with chronic hepatitis delta virus infection (CHD) is limited to interferon alpha with rare curative outcome. Myrcludex B is a first-in-class entry inhibitor inactivating the hepatitis B virus (HBV) and hepatitis D virus (HDV) receptor sodium taurocholate co-transpo...

journal_title：Journal of hepatology

authors： Bogomolov P,Alexandrov A,Voronkova N,Macievich M,Kokina K,Petrachenkova M,Lehr T,Lempp FA,Wedemeyer H,Haag M,Schwab M,Haefeli WE,Blank A,Urban S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND & AIMS:Ventriculo-arterial coupling (VAC) reflects the interaction between ventricular performance and effective arterial load. Current criteria for cirrhotic cardiomyopathy focus only on cardiac function without addressing the effect of hyperdynamic, low-resistance circulation. We investigated alterations i...

journal_title：Journal of hepatology

authors： Shin WJ,Song JG,Jun IG,Moon YJ,Kwon HM,Jung K,Kim SO,Hwang GS

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...

journal_title：Journal of hepatology

authors： Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND/AIMS:Thrombin and MC tryptase, which are agonists for proteinase-activated receptors-1 and -2, respectively, are both increased in injured liver. We have examined if rat stellate cells express these receptors and if receptor agonists influence stellate cell activation. METHODS:Expression of mRNA for protein...

journal_title：Journal of hepatology

authors： Gaça MD,Zhou X,Benyon RC

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND & AIMS:Serological markers of hepatocellular carcinoma (HCC) indicate its invasiveness. We aimed to investigate whether the prognostic impact of surgical resection (SR) and radiofrequency thermal ablation (RFA) on patients with single nodular HCC ⩽5cm were different regarding positive conditions of the follo...

journal_title：Journal of hepatology

authors： Ueno M,Hayami S,Shigekawa Y,Kawai M,Hirono S,Okada K,Tamai H,Shingaki N,Mori Y,Ichinose M,Yamaue H

更新日期：2015-12-01 00:00:00

abstract：:An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations...

journal_title：Journal of hepatology

authors： Kremsdorf D,Garreau F,Duclos H,Thiers V,Schellekens H,Petit MA,Bréchot C

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND/AIM:Smooth muscle antibodies and antinuclear antibodies characterize type 1 autoimmune hepatitis. Our aim was to correlate the appearance and disappearance of these autoantibodies with clinical and histological events. METHODS:One hundred and seven patients were evaluated successively over 128+/-9 months. A...

journal_title：Journal of hepatology

authors： Czaja AJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIMS:Intestinal microflora plays an important role in the pathogenesis of neonatal jaundice by inhibiting enterosystemic circulation of bilirubin. The present study aimed to investigate the influence of intestinal microflora on serum bilirubin levels in hyperbilirubinemic Gunn rats. METHODS:After a baseline...

journal_title：Journal of hepatology

authors： Vítek L,Zelenka J,Zadinová M,Malina J

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND/AIMS:Pegylated interferon plus ribavirin can cause dose-limiting anemia. Taribavirin, a ribavirin prodrug, has shown a lower incidence of anemia. We sought to determine the efficacy and safety of taribavirin vs. ribavirin combined with pegylated interferon in patients with chronic hepatitis C (CHC). METHODS...

journal_title：Journal of hepatology

authors： Gish RG,Arora S,Rajender Reddy K,Nelson DR,O'Brien C,Xu Y,Murphy B

更新日期：2007-07-01 00:00:00