Abstract：
BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guidelines. However, the best indication and appropriateness of the algorithm for TACE are still unclear. METHODS:In 4966 HCC patients who underwent TACE, survival was evaluated based on tumor number, size and liver function; and the adequacy of the algorithm for TACE was validated. Exclusion criteria were: vascular invasion, extrahepatic metastasis, and prior treatment. The mean follow up period was 1.6 years. RESULTS:The overall median and 5-year survivals were 3.3 years and 34%, respectively. Multivariate analysis revealed that Child-Pugh class, tumor number, size, alpha-fetoprotein, and des-gamma carboxy-prothrombin were independent predictors. The survival rate decreased as the tumor number (p=0.0001) and size increased (p=0.04 to p=0.0001) in all but one subgroup in both Child-Pugh-A and -B. The stratification of these patients to four treatments in the algorithm showed potential ability to discriminate survivals of the resection and ablation (non-TACE) groups from those of the TACE group in Child-Pugh-B and partially in A. CONCLUSIONS:TACE showed higher survival rates in patients with fewer tumor numbers, smaller tumor size, and better liver function. The treatment algorithm proposed by the Japanese guidelines might be appropriate to discriminate the survival of patients with non-TACE from TACE therapy.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi Mdoi
10.1016/j.jhep.2011.10.021subject
Has Abstractpub_date
2012-04-01 00:00:00pages
886-92issue
4eissn
0168-8278issn
1600-0641pii
S0168-8278(11)00865-8journal_volume
56pub_type
杂志文章abstract：BACKGROUND/AIMS:The roles of T cells, natural killer T cells (NKT) and macrophages in autoimmune hepatitis have been well documented. However, the roles of natural killer (NK) cells in liver injury remain obscure. Here we examined the effect of Polyinosinic: polycytidylic acid (PolyI:C)-activated NK cells on liver inju...
journal_title：Journal of hepatology
pub_type： 杂志文章
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更新日期：2004-12-01 00:00:00
abstract：BACKGROUND/AIMS:Bio-artificial liver support systems for treatment of hepatic failure require maintained expression of hepatocyte function in vitro. We studied cultures of human hepatocyte cell-lines proliferating within alginate beads, investigating the hypothesis that 3-dimensional cohesive colonies of hepatocyte cel...
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pub_type： 杂志文章
doi：10.1016/s0168-8278(00)00080-5
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND/AIMS:As conditional knockout mice for stat3 are impaired in liver regeneration after partial hepatectomy while those for gp130 have defects in early STAT3 phosphorylation but have normal DNA synthesis, late STAT3 phosphorylation induced independently of gp130 seems to be essential for liver regeneration. Sin...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2007.08.020
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND/AIMS:Copper toxicosis (CT) in Bedlington terriers is an autosomal recessive disorder characterized by massive lysosomal copper accumulation in livers of affected dogs, and a defect in the biliary excretion of this metal. We propose that MURR1, the gene defective in canine CT, has a role in the regulation of ...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(03)00380-5
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND/METHODS:We recently established two hepatitis C virus (HCV) replication systems, using MT-2, a human T-cell leukemia virus type I-infected human T-cell line, and PH5CH, a non-neoplastic human hepatocyte line immortalized with simian virus 40 large T antigen. These HCV replication systems were used to assess ...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(97)80347-9
更新日期：1997-09-01 00:00:00
abstract：:Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause. The findings are described in detail in...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(86)80087-3
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND/AIMS:Liver negative-strand hepatitis C virus (HCV) RNA is the most direct indicator of active viral replication but has only been examined in a few semiquantitative studies. METHODS:Positive- and negative-strand HCV RNA in the right (R) and left (L) liver lobes was quantified by rTth-based strand-specific r...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2005.10.014
更新日期：2006-02-01 00:00:00
abstract：:Short- and long-term effects of intraperitoneally transplanted microcarrier attached liver cells (MAL) have been studied in two experimental models of severe liver insufficiency in the rat: subtotal hepatectomy (HX) and acute liver ischemia. Intraperitoneal transplantation of MAL immediately after subtotal hepatectomy...
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pub_type： 杂志文章
doi：10.1016/0168-8278(89)90075-5
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pub_type： 杂志文章
doi：10.1016/s0168-8278(98)80225-0
更新日期：1998-05-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jhep.2012.07.015
更新日期：2012-12-01 00:00:00
abstract：:It has been postulated that one of the mechanisms of hypotension associated with cirrhosis is an attenuated responsiveness to catecholamines despite the increased activity of the sympathetic nervous system and the elevated plasma concentrations of the sympathetic neurotransmitter, norepinephrine. This abnormality was ...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(05)80531-8
更新日期：1993-01-01 00:00:00
abstract：:To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 patients with chronic liver disease and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 patients and 21 healthy subjects. Postprandial portal veno...
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pub_type： 杂志文章
doi：10.1016/s0168-8278(05)80603-8
更新日期：1994-12-01 00:00:00
abstract：:Hepatitis B virus (HBV) remains a major risk of transfusion-transmitted infection due to the pre-seroconversion window period (WP), infection with immunovariant viruses, and with occult carriage of HBV infection (OBI). Reduction of HBV residual risk depends upon developing more sensitive HBV surface antigen (HBsAg) te...
journal_title：Journal of hepatology
pub_type： 杂志文章,评审
doi：10.1016/j.jhep.2009.05.020
更新日期：2009-10-01 00:00:00
abstract：:Portal hypertension is the main cause of complications in patients with chronic liver disease. Over the past 25 years, progress in the understanding of the pathophysiology of portal hypertension was followed by the introduction of an effective pharmacological therapy, consisting mainly of treatments aimed at correctin...
journal_title：Journal of hepatology
pub_type： 杂志文章,评审
doi：10.1016/j.jhep.2010.03.021
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND & AIMS:In developed countries, hepatitis E is usually associated with travelling to endemic areas, but a growing number of sporadic cases are also seen in patients with no travel history. The aim of this study was to assess the impact and the molecular epidemiology of hepatitis E in Italy. METHODS:Between J...
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pub_type： 杂志文章
doi：10.1016/j.jhep.2010.06.017
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND & AIMS:Current techniques for predicting outcome and requirement for emergency liver transplantation (ELT) in acute liver failure (ALF) are imperfect, though The Kings College Criteria (KCC) are the most commonly applied tools for this purpose. Their performance in identification of patients with non-paracet...
journal_title：Journal of hepatology
pub_type： 杂志文章,meta分析
doi：10.1016/j.jhep.2010.03.023
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Platelet cytosolic calcium is necessary for normal platelet function, and may reflect intracellular signalling in vascular smooth muscle cells. METHODS:The cytosolic calcium of platelets from patients with cirrhosis and control subjects was measured in contact with plasma from either source, using FURA 2AM....
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pub_type： 杂志文章
doi：10.1016/s0168-8278(96)80117-6
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND & AIMS:During chronic HCV infection, T cell dependent virus-specific antibodies are produced. However, the role of B-T cell interaction in chronic HCV is largely unknown. CD4(+)CXCR5(+) T follicular helper (TFH)-cells activate B cells and are important for clearance of various chronic viral infections. We in...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2014.09.024
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND & AIMS:Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to trans...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2009.10.006
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND/AIMS:Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, th...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2009.04.012
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND & AIMS:Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis. The aim of this nationwide registry study was to describe renal disease in Swedish patients with CHC. ME...
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pub_type： 杂志文章
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journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2010.09.019
更新日期：2011-06-01 00:00:00
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journal_title：Journal of hepatology
pub_type： 杂志文章,评审
doi：10.1016/j.jhep.2008.02.005
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND & AIMS:The pathomechanisms underlying non-alcoholic fatty liver disease (NAFLD) and the involved molecular regulators are incompletely explored. The nuclear factor-kappa B (NF-κB)-cofactor gene B cell leukemia-3 (Bcl-3) plays a critical role in altering the transcriptional capacity of NF-κB - a key inducer o...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2016.06.026
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(02)00413-0
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND/AIMS:[corrected] Hepatobiliary carcinoma (HBC) has been considered to be a late complication of end-stage primary sclerosing cholangitis (PSC). The incidence of HBC is approximately 20% in PSC patients evaluated for liver transplantation. The diagnosis of HBC is difficult, at least at an early stage and the ...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/s0168-8278(01)00042-3
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND/AIMS:In acute liver injury, fibronectin (FN) is deposited at the site of hepatocellular necrosis. We have previously shown that liver inflammatory mononuclear phagocytes (MNP), in contrast to quiescent hepatic macrophages, synthesize abundant amounts of FN. We now analyzed effects of agents known to influenc...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2003.12.013
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND/AIMS:Patients with hepatic encephalopathy show altered motor function, psychomotor slowing and hypokinesia. The underlying mechanisms remain unclear. This work's aims were: (1) to analyse in rats with chronic liver failure due to portacaval shunt (PCS) the neurochemical alterations in the basal ganglia-thala...
journal_title：Journal of hepatology
pub_type： 杂志文章
doi：10.1016/j.jhep.2006.06.019
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND/AIMS:The factors which predict the long-term outcome in patients with hepatocellular carcinoma who are treated with percutaneous laser ablation (PLA) are not well established. METHODS:We prospectively analyzed treatment and survival parameters of 148 cirrhotic patients with nonsurgical hepatocellular carcin...
journal_title：Journal of hepatology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jhep.2006.01.031
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND/AIMS:To assess the efficacy and safety of naltrexone for the short and long term treatment of pruritus of cholestasis. METHODS:Twenty patients with pruritus and cholestasis were included. A baseline pruritus score was obtained over 1 week. Patients were then randomized to receive 50 mg/day of naltrexone or ...
journal_title：Journal of hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0168-8278(02)00318-5
更新日期：2002-12-01 00:00:00
