Hepatobiliary carcinoma in primary sclerosing cholangitis: a case control study.


BACKGROUND/AIMS:[corrected] Hepatobiliary carcinoma (HBC) has been considered to be a late complication of end-stage primary sclerosing cholangitis (PSC). The incidence of HBC is approximately 20% in PSC patients evaluated for liver transplantation. The diagnosis of HBC is difficult, at least at an early stage and the prognosis is poor even after liver transplantation. The aim of the study was to look for signs and risk factors for developing hepatobiliary carcinoma in patients with PSC. METHODS:Thirty-six consecutive patients with PSC and HBC (32 with bile duct carcinoma, BDC, and four with hepatocellular carcinoma, HCC) were pair-matched to control patients referred for liver transplantation because of PSC but who did not have HBC. Gender and age at referral were used as matching factors. Clinical and biochemical data were registered. RESULTS:PSC patients with BDC had a shorter median duration of PSC (1 year) compared with the controls (7 years) and PSC patients with HCC (8 years). There were no statistically significant differences in the liver biochemistry between the patient groups. Varices were more common in patients with PSC and HCC (100%) than in controls (56%) or patients with PSC and HBC (12%) (P < 0.0005). CONCLUSIONS:The relatively short duration of PSC and the absence of varices in patients with BDC suggest that BDC, unlike HCC, is not necessarily a late complication of end-stage PSC, as was previously assumed.


J Hepatol


Journal of hepatology


Leidenius M,Höckersted K,Broomé U,Ericzon BG,Friman S,Olausson M,Schrumpf E




Has Abstract


2001-06-01 00:00:00














  • Host- and disease-specific factors affecting steatosis in chronic hepatitis C.

    abstract:BACKGROUND/AIM:Steatosis is commonly present in chronic hepatitis C. Our aim was to evaluate host- and disease-specific factors associated with its occurrence. METHODS:Histologic findings in 60 patients were correlated with body mass index, human leukocyte antigens, and other conventional parameters. Comparisons were ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Czaja AJ,Carpenter HA,Santrach PJ,Moore SB

    更新日期:1998-08-01 00:00:00

  • Hepatopulmonary syndrome in candidates for liver transplantation.

    abstract:BACKGROUND:Hepatopulmonary syndrome (HPS) has been defined as a clinical triad, including chronic liver disease, gas exchange defects (increased alveolar-arterial PO2 difference irrespective of the presence of arterial hypoxemia), and widespread intrapulmonary vascular dilatations. We determined the incidence and the c...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Martínez GP,Barberà JA,Visa J,Rimola A,Paré JC,Roca J,Navasa M,Rodés J,Rodriguez-Roisin R

    更新日期:2001-05-01 00:00:00

  • Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

    abstract:BACKGROUND & AIMS:Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bankwitz D,Doepke M,Hueging K,Weller R,Bruening J,Behrendt P,Lee JY,Vondran FWR,Manns MP,Bartenschlager R,Pietschmann T

    更新日期:2017-09-01 00:00:00

  • Defective aggregation in cirrhosis is independent of in vivo platelet activation.

    abstract:BACKGROUND/AIMS:Platelet function abnormalities contribute to the hemostatic defect in patients with cirrhosis. In this study we evaluated the occurrence of in vivo platelet activation as a possible mechanism of defective platelet aggregation in patients with cirrhosis. METHODS:Nine patients with severe (Child B-C) ci...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Laffi G,Cinotti S,Filimberti E,Ciabattoni G,Caporale R,Marra F,Melani L,Grossi A,Carloni V,Gentilini P

    更新日期:1996-04-01 00:00:00

  • Occurrence of porphyria cutanea tarda during peginterferon/ribavirin therapy for chronic viral hepatitis C.

    abstract::Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by a reduced hepatic activity of uroporphynogen decarboxylase (URO-D), an enzyme of the heme synthesis. The clinical features of PCT may be brought into light by hepatic injury induced by hepatitis C virus (HCV). A significant association between HCV ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Thevenot T,Bachmeyer C,Hammi R,Dumouchel P,Ducamp-Posak I,Cadranel JF

    更新日期:2005-04-01 00:00:00

  • Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associa...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ji J,Zhao L,Budhu A,Forgues M,Jia HL,Qin LX,Ye QH,Yu J,Shi X,Tang ZY,Wang XW

    更新日期:2010-05-01 00:00:00

  • A performance evaluation of the expert system 'Jaundice' in comparison with that of three hepatologists.

    abstract::The diagnostic performance of an Expert System (Jaundice) designed to discriminate between different causes of jaundice was evaluated in a test sample of 200 consecutive in-patients with serum bilirubin greater than or equal to 51 mumol/l. The average probability assigned to true diagnosis, the non-error rate and the ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Cammà C,Garofalo G,Almasio P,Tinè F,Craxì A,Palazzo U,Pinzello G,Fiorello F,Angelo PM,Pagliaro L

    更新日期:1991-11-01 00:00:00

  • Bile duct bacterial isolates in primary sclerosing cholangitis: a study of explanted livers.

    abstract:BACKGROUND/AIMS:The pathogenesis of the inflammatory lesion in primary sclerosing cholangitis is unknown. The clinical picture is characterized by i.a. episodes of fever, the cause of which also remains speculative. Previous studies of bacterial isolates in the liver or bile ducts in primary sclerosing cholangitis have...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Olsson R,Björnsson E,Bäckman L,Friman S,Höckerstedt K,Kaijser B,Olausson M

    更新日期:1998-03-01 00:00:00

  • The role of serial measurement of serum HBV DNA levels in patients with chronic HBeAg(-) hepatitis B infection: association with liver disease progression. A prospective cohort study.

    abstract:BACKGROUND/AIMS:To evaluate the fluctuating course of serum HBV-DNA levels during the natural history of chronic HBV infection in the general population of North-Eastern Greece, in association with liver disease progression. METHODS:Two hundred and sixty-three adults with chronic HBV, median 34 years of age, were rand...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zacharakis G,Koskinas J,Kotsiou S,Tzara F,Vafeiadis N,Papoutselis M,Maltezos E,Sivridis E,Papoutselis K

    更新日期:2008-12-01 00:00:00

  • Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoni.

    abstract:BACKGROUND/AIMS:The tropical parasite Schistosoma mansoni causes granulomatous inflammation following lodging of eggs in portal capillaries. In vitro studies indicated that the host reaction should involve reactive oxygen intermediates; however, it is not known what occurs in vivo at the site of the disease. Moreover, ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Gharib B,Abdallahi OM,Dessein H,De Reggi M

    更新日期:1999-04-01 00:00:00

  • Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.

    abstract:BACKGROUND & AIMS:Acetaminophen (APAP)-induced liver injury is the most frequent cause of acute liver failure in the US and many other countries. Metabolism of APAP results in formation of APAP protein adducts (APAP-AD) in hepatocytes and triggers mitochondrial dysfunction and necrosis. However, the mechanisms for how ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ni HM,McGill MR,Chao X,Du K,Williams JA,Xie Y,Jaeschke H,Ding WX

    更新日期:2016-08-01 00:00:00

  • Expression of HLA antigens and T cell infiltrates in chronic viral hepatitis. A comparison of biopsy and fine-needle aspiration findings.

    abstract::To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

    更新日期:1991-03-01 00:00:00

  • Agreement between reported use of interventions for liver diseases and research evidence in Cochrane systematic reviews.

    abstract:BACKGROUND/AIMS:This study evaluates the agreement between reported use of interventions for patients with liver diseases and research evidence in Cochrane systematic reviews. METHODS:In July 2002, the Cochrane Hepato-Biliary Group had completed 28 systematic reviews on 36 interventions that were available in Denmark....

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kürstein P,Gluud LL,Willemann M,Olsen KR,Kjellberg J,Sogaard J,Gluud C

    更新日期:2005-12-01 00:00:00

  • Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.

    abstract:BACKGROUND & AIMS:Interleukin-6 (IL-6) is a crucial factor in liver regeneration following partial hepatectomy (PH); however, the role of IL-6 and IL-6 trans-signaling in particular, in hepatocyte mitosis remains controversial. IL-6 trans-signaling relies upon the release of the soluble IL-6R (sIL-6R), which binds IL-6...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Nechemia-Arbely Y,Shriki A,Denz U,Drucker C,Scheller J,Raub J,Pappo O,Rose-John S,Galun E,Axelrod JH

    更新日期:2011-05-01 00:00:00

  • Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

    abstract:BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

    更新日期:2011-12-01 00:00:00

  • Pancreatic Duodenal Homeobox-1 de novo expression drives cholangiocyte neuroendocrine-like transdifferentiation.

    abstract:BACKGROUND & AIMS:Reactive cholangiocytes acquire a neuroendocrine-like phenotype, with synthesis and local release of neuropeptides and hormones. The mechanism that drives such phenotypical changes is still undefined. Pancreatic Duodenal Homeobox-1 (PDX-1) is a transcription factor required for pancreatic development,...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Marzioni M,Saccomanno S,Candelaresi C,Rychlicki C,Agostinelli L,Shanmukhappa K,Trozzi L,Pierantonelli I,De Minicis S,Benedetti A

    更新日期:2010-10-01 00:00:00

  • Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients.

    abstract:BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

    更新日期:2009-02-01 00:00:00

  • Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection.

    abstract:BACKGROUND & AIMS:HCV requires host lipid metabolism for replication, and apolipoproteins have been implicated in the response to treatment. METHODS:We examined plasma apolipoprotein concentrations in three cohorts of patients: mono-infected patients with symptomatic acute hepatitis C (aHCV); those undergoing treatmen...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Laird ME,Mohsen A,Duffy D,Mamdouh R,LeFouler L,Casrouge A,El-Daly M,Rafik M,Abdel-Hamid M,Soulier A,Pawlotsky JM,Hézode C,Rosa I,Renard P,Mohamed MK,Bonnard P,Izopet J,Mallet V,Pol S,Albert ML,Fontanet A

    更新日期:2014-10-01 00:00:00

  • Menopausal age and sex hormones in postmenopausal women with alcoholic and non-alcoholic liver disease.

    abstract::In order to evaluate age at menopause and serum sex hormone profiles in postmenopausal women with stable chronic liver disease, six non-cirrhotic alcoholics, 13 with alcoholic cirrhosis, eight with non-alcoholic cirrhosis, and 46 healthy controls were studied. In all three groups, patients were significantly (p less t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Becker U,Gluud C,Farholt S,Bennett P,Micic S,Svenstrup B,Hardt F

    更新日期:1991-07-01 00:00:00

  • The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of th...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM

    更新日期:2013-07-01 00:00:00

  • Can antiviral therapy for hepatitis C reduce the prevalence of HCV among injecting drug user populations? A modeling analysis of its prevention utility.

    abstract:BACKGROUND & AIMS:Hepatitis C virus antiviral treatment is effective for individual patients but few active injecting drug users are treated. We considered the utility of antiviral treatment for primary prevention of hepatitis C. METHODS:A hepatitis C transmission model among injecting drug users was developed, incorp...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Martin NK,Vickerman P,Foster GR,Hutchinson SJ,Goldberg DJ,Hickman M

    更新日期:2011-06-01 00:00:00

  • Clinical implications of GBV-C/HGV infection in patients with "HCV-related" chronic hepatitis.

    abstract:BACKGROUND/AIMS:To evaluate the clinical, biochemical and histological implications of a concomitant HGV infection in "HCV-related" chronic liver disease. METHODS:Eighty-three HCV-RNA positive patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR. RESULTS:Twenty-two (26.5%) patie...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Francesconi R,Giostra F,Ballardini G,Manzin A,Solforosi L,Lari F,Descovich C,Ghetti S,Grassi A,Bianchi G,Zauli D,Clementi M,Bianchi FB

    更新日期:1997-06-01 00:00:00

  • Management of hepatitis C: current and future perspectives.

    abstract::Chronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. In March 1997, the National Institutes of Health sponsored a Consensus Development Conference entitled "Management of Hepatitis C". The final statement from the Consensus Panel set forth clear, evidence-based gui...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hoofnagle JH

    更新日期:1999-01-01 00:00:00

  • Regional sympathetic activity, severity of liver disease and hemodynamics in patients with cirrhosis.

    abstract::One hundred and eight patients with cirrhosis (23 grade A, 46 grade B and 39 grade C, according to Pugh's classification) underwent hemodynamic studies and plasma catecholamine concentration measurements. Blood samples were withdrawn from the pulmonary artery (n = 108), the hepatic vein (n = 108), the azygos vein (n =...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Gaudin C,Braillon A,Poo JL,Moreau R,Hadengue A,Lebrec D

    更新日期:1991-09-01 00:00:00

  • Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.

    abstract:BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

    更新日期:1997-10-01 00:00:00

  • miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.

    abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been extensively studied in hepatocarcinogenesis. However, the role of miR-122 in liver fibrosis remains unknown. METHODS:The mRNA expression levels of miR-122, prolyl...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Li J,Ghazwani M,Zhang Y,Lu J,Li J,Fan J,Gandhi CR,Li S

    更新日期:2013-03-01 00:00:00

  • Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices.

    abstract:BACKGROUND/AIMS:Periodic endoscopic screening for oesophageal varices is recommended in patients with cirrhosis, but might be limited to a subgroup of patients if a simple non-invasive test was available to select those at risk of bleeding. METHODS:We studied in 165 patients with cirrhosis the relation between the pre...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kazemi F,Kettaneh A,N'kontchou G,Pinto E,Ganne-Carrie N,Trinchet JC,Beaugrand M

    更新日期:2006-08-01 00:00:00

  • Dendritic cell maturation in HCV infection: altered regulation of MHC class I antigen processing-presenting machinery.

    abstract:BACKGROUND & AIMS:Modulation of dendritic cell (DC) function has been theorized as one of the mechanisms used by hepatitis C virus (HCV) to evade the host immune response and cause persistent infection. METHODS:We used a range of cell and molecular biology techniques to study DC subsets from uninfected and HCV-infecte...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Leone P,Di Tacchio M,Berardi S,Santantonio T,Fasano M,Ferrone S,Vacca A,Dammacco F,Racanelli V

    更新日期:2014-08-01 00:00:00

  • Fatal ischemic acute pancreatitis complicating trans-catheter arterial embolization of small hepatocellular carcinoma: do the risks outweigh the benefits?

    abstract::Hepatocellular carcinoma (HCC) is an accepted indication for liver transplantation (LT). Pre-LT adjuvant ablation treatments to prevent tumour progression and drop out from the waiting list have been increasingly adopted at most transplant centers. Trans-catheter arterial chemo-embolization (TACE) is frequently used, ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Addario L,Di Costanzo GG,Tritto G,Cavaglià E,Angrisani B,Ascione A

    更新日期:2008-07-01 00:00:00

  • Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.

    abstract:BACKGROUND/AIMS:Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing. The objective of this retrospective study is to assess the safety and effectiveness ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Reddy SK,Kishnani PS,Sullivan JA,Koeberl DD,Desai DM,Skinner MA,Rice HE,Clary BM

    更新日期:2007-11-01 00:00:00