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Occurrence of porphyria cutanea tarda during peginterferon/ribavirin therapy for chronic viral hepatitis C.

Abstract：

:Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by a reduced hepatic activity of uroporphynogen decarboxylase (URO-D), an enzyme of the heme synthesis. The clinical features of PCT may be brought into light by hepatic injury induced by hepatitis C virus (HCV). A significant association between HCV and PCT is well recognized, although the role of HCV in the appearance of PCT is still debated because confounding factors often coexist, such as alcohol, other viruses, drugs or iron overload (). HCV therapy may improve PCT although PCT was rarely reported as a de novo occurrence during an interferon/ribavirin therapy (Jessner et al. Hepatology 2002;36:1301-1302); here, we describe two such other cases.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Thevenot T,Bachmeyer C,Hammi R,Dumouchel P,Ducamp-Posak I,Cadranel JF

doi

10.1016/j.jhep.2004.10.029

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

607-8

issue

4

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(04)00553-7

journal_volume

42

pub_type

杂志文章

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