当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Gastro-oesophageal reflux and alcoholic cirrhosis. A reappraisal.

Gastro-oesophageal reflux and alcoholic cirrhosis. A reappraisal.

Abstract：

:The oesophageal pH was recorded for 3 h after a test-meal in 27 healthy control subjects (group I), 40 patients with alcoholic cirrhosis (group II), and 22 patients with a normal liver and symptoms of gastro-oesophageal reflux (control refluxers). Gastro-oesophageal reflux was observed in 10 of the cirrhotic patients. Marked reflux episodes lasted longer in cirrhotic refluxers than in control refluxers (P less than 0.05). The frequency of ascites, bleeding from ruptured oesophageal varices, peripheral neuropathy and hepatic encephalopathy were not significantly different according to presence or absence of reflux. Plasma concentrations of gastrin, somatostatin, motilin and vasoactive intestinal peptide (VIP) were measured in groups I and II. Fasting plasma motilin levels, and the release of motilin and of VIP after the meal were higher in group II than in group I. Basal levels and post-prandial profiles of the four peptides tested did not differ between cirrhotics with or without gastro-oesophageal reflux. We conclude that in patients with alcoholic cirrhosis: gastro-oesophageal reflux is frequent (25%) and characterized by prolonged reflux episodes; reflux is not correlated with the degree of liver failure and plays no significant role in the rupture of oesophageal varices; and raised plasma motilin and VIP levels cannot account for the high incidence of reflux in cirrhotics.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Arsene D,Bruley des Varannes S,Galmiche JP,Denis P,Chayvialle JA,Hellot MF,Ducrotte P,Colin R

doi

10.1016/s0168-8278(87)80088-0

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

250-8

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(87)80088-0

journal_volume

4

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Transplantation of the liver in adults and children with fulminant hepatic failure.

    abstract：:Fulminant hepatic failure has a high mortality rate despite intensive medical treatment. Urgent hepatic transplantation was considered over a 3 year period in 26 (36%) of 73 patients with the worst prognostic features of fulminant hepatic failure. The criteria for patient selection were based on the duration of advanc...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80475-6

    authors： Vickers C,Neuberger J,Buckels J,McMaster P,Elias E

    更新日期：1988-10-01 00:00:00

  • Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.

    abstract：BACKGROUND & AIMS:It is widely recognized that in the early stages of liver regeneration after partial hepatectomy, the hepatocytes accumulate a significant amount of lipids. The functional meaning of this transient steatosis and its effect on hepatocellular proliferation are not well defined. In addition, the basic me...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.05.026

    authors： Pauta M,Rotllan N,Vales F,Fernandez-Hernando A,Allen RM,Ford DA,Marí M,Jiménez W,Baldán A,Morales-Ruiz M,Fernández-Hernando C

    更新日期：2013-10-01 00:00:00

  • Lactitol versus lactulose in the treatment of chronic hepatic encephalopathy. A double-blind, randomised, cross-over study.

    abstract：:Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. The efficacy of lactitol in the treatment of chronic hepatic encephalopathy was assessed in 9 cirrhotic patients in a randomised, double-blind, cross-over comparison with lactulose. The sugars were dispensed in solutions,...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(87)80086-7

    authors： Morgan MY,Hawley KE,Stambuk D

    更新日期：1987-04-01 00:00:00

  • Delta infection in the Naples area. Epidemiologic and clinical significance.

    abstract：:To define the epidemiologic and clinical significance of delta infection in the Naples area, we sought anti-delta antibodies in all cases of HBV-associated liver diseases, hospitalized in our department during 1983 (234 acute hepatitis, 9 of which fulminant; 51 chronic hepatitis; 32 cirrhosis; 19 hepatocarcinomas) and...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80003-4

    authors： Amoroso P,Giorgio A,Fico P,Lettieri G,de Stefano G,Scala V,Pesce G,Pierri P,Pempinello R,Finelli L

    更新日期：1986-01-01 00:00:00

  • Transfusion-transmitted hepatitis B virus infection.

    abstract：:Hepatitis B virus (HBV) remains a major risk of transfusion-transmitted infection due to the pre-seroconversion window period (WP), infection with immunovariant viruses, and with occult carriage of HBV infection (OBI). Reduction of HBV residual risk depends upon developing more sensitive HBV surface antigen (HBsAg) te...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2009.05.020

    authors： Candotti D,Allain JP

    更新日期：2009-10-01 00:00:00

  • Effects of ursodeoxycholate, its glucuronide and disulfate and beta-muricholate on biliary bicarbonate concentration and biliary lipid excretion.

    abstract：:We previously reported that high-dose ursodeoxycholate (UDC) infusion in rats resulted in extensive glucuronidation of UDC, and speculated that the glucuronidation causes bicarbonate-rich hypercholeresis induced by UDC (Takikawa, H., Sano, N., Narita, T. and Yamanaka, M. Hepatology 1990; 11: 743-749). To test this hyp...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90015-h

    authors： Takikawa H,Sano N,Minagawa K,Yamanaka M

    更新日期：1992-05-01 00:00:00

  • Sustained virological response to antiviral therapy reduces mortality in HCV reinfection after liver transplantation.

    abstract：BACKGROUND/AIMS:HCV infection recurs almost in all HCV-positive patients receiving liver transplantation and carries a poor prognosis. Aim of this study was to analyze efficacy and effect on survival of antiviral therapy in this clinical setting. METHODS:Pegylated-interferon alpha-2b and ribavirin were administered at...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jhep.2006.10.017

    authors： Picciotto FP,Tritto G,Lanza AG,Addario L,De Luca M,Di Costanzo GG,Lampasi F,Tartaglione MT,Marsilia GM,Calise F,Cuomo O,Ascione A

    更新日期：2007-03-01 00:00:00

  • Blunted postprandial reaction of portal venous flow in chronic liver disease, assessed with duplex Doppler: significance for prognosis.

    abstract：:To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 patients with chronic liver disease and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 patients and 21 healthy subjects. Postprandial portal veno...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80603-8

    authors： de Vries PJ,de Hooge P,Hoekstra JB,van Hattum J

    更新日期：1994-12-01 00:00:00

  • Reducing environment protects sinusoidal lymphocytes isolated from normal human liver from apoptosis.

    abstract：BACKGROUND/AIMS:We previously reported that the populations of lymphocytes and the expression of activated antigens in human sinusoidal mononuclear cells were different from those in peripheral blood mononuclear cells. Attempts to culture these cells for further study failed because they died rapidly under standard cul...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80016-5

    authors： Kinoshita K,Kanai M,Awane M,Furuke K,Shirakata Y,Gomi T,Nakamura Y,Ikai I,Yamauchi A,Inamoto T,Ohmori K,Yamaoka Y

    更新日期：1997-01-01 00:00:00

  • Management of adverse events with tailored sorafenib dosing prolongs survival of hepatocellular carcinoma patients.

    abstract：BACKGROUND & AIMS:Sorafenib is associated with multiple adverse events (AEs), potentially causing its permanent interruption. It is unknown how physicians' experience has impacted on the management of these AEs and consequently on clinical outcomes. We aimed to assess whether AE management changed over time and if thes...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.08.015

    authors： Tovoli F,Ielasi L,Casadei-Gardini A,Granito A,Foschi FG,Rovesti G,Negrini G,Orsi G,Renzulli M,Piscaglia F

    更新日期：2019-12-01 00:00:00

  • Natural history of chronic hepatitis B in Euro-Mediterranean and African countries.

    abstract：:Data derived from population, case-control, and cohort studies conducted in several Euro-Mediterranean and African countries disclose impressive similarities in the age and modes of hepatitis B virus (HBV) transmission and in the prevalence, duration, and outcome of the four phases of the natural history of chronic in...

    journal_title：Journal of hepatology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.jhep.2010.12.030

    authors： Hadziyannis SJ

    更新日期：2011-07-01 00:00:00

  • Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.

    abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80091-8

    authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

    更新日期：1997-10-01 00:00:00

  • Prevalence of hepatitis C viral infection in a community in Taiwan. Detection by synthetic peptide-based assay and polymerase chain reaction.

    abstract：:The prevalence of antibodies to hepatitis C virus (anti-HCV) in a hepatitis B virus hyperendemic region was evaluated with a second-generation enzyme immunoassay. A general population of 1500 from Northern Taiwan was tested with this immunoassay which includes synthetic peptides from the capsid and non-structural prot...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80037-6

    authors： Sheu JC,Wang JT,Wang TH,Wang CY,Yang PM,Huang GT,Shih LN,Lee HS,Chen DS

    更新日期：1993-02-01 00:00:00

  • Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

    abstract：BACKGROUND & AIMS:Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient G...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.12.015

    authors： Wittlich M,Dudek M,Böttcher JP,Schanz O,Hegenbarth S,Bopp T,Schmitt E,Kurts C,Garbers C,Rose John S,Knolle PA,Wohlleber D

    更新日期：2017-05-01 00:00:00

  • Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

    abstract：BACKGROUND/AIMS:Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion will engraft. Such cells can promote liver repair in rodent models of liver injury and lead to improved liver function in uncontrolled clinical studies. In order t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.06.021

    authors： Crosby HA,Lalor PF,Ross E,Newsome PN,Adams DH

    更新日期：2009-10-01 00:00:00

  • Experimental cholestatic liver disease through bile-duct ligation in rats results in skeletal fragility and impaired osteoblastogenesis.

    abstract：BACKGROUND/AIMS:Patients with cholestatic liver disease have 'low-turnover' osteoporosis. Since we reported that bile-duct ligated (BDL) rats develop bone disease with low bone formation and mass, we examined whether their reduced bone mass results in skeletal fragility, and whether the reduction in osteoprogenitor cel...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.11.032

    authors： Weinreb M,Pollak RD,Ackerman Z

    更新日期：2004-03-01 00:00:00

  • Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra.

    abstract：BACKGROUND/AIMS:Patients with hepatic encephalopathy show altered motor function, psychomotor slowing and hypokinesia. The underlying mechanisms remain unclear. This work's aims were: (1) to analyse in rats with chronic liver failure due to portacaval shunt (PCS) the neurochemical alterations in the basal ganglia-thala...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.06.019

    authors： Cauli O,Llansola M,Erceg S,Felipo V

    更新日期：2006-11-01 00:00:00

  • Treatment of hepatitis B-related polyarteritis nodosa with famciclovir and interferon alfa-2b.

    abstract：BACKGROUND:The association between polyarteritis nodosa and viral hepatitis B infection is well established and still remains a therapeutic challenge. Famciclovir--a new nucleoside analog--has a broad spectrum of antiviral activity against herpes viruses and the human hepatitis B virus. CASE REPORT:A 56-year-old man w...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80263-2

    authors： Kruger M,Böker KH,Zeidler H,Manns MP

    更新日期：1997-04-01 00:00:00

  • Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α.

    abstract：BACKGROUND & AIMS:Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and func...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.07.025

    authors： Chen KT,Pernelle K,Tsai YH,Wu YH,Hsieh JY,Liao KH,Guguen-Guillouzo C,Wang HW

    更新日期：2014-12-01 00:00:00

  • Tumour suppressors in liver carcinogenesis.

    abstract：:The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in check and if impaired, can alter a delicate balance in favour of...

    journal_title：Journal of hepatology

    pub_type：

    doi：10.1016/j.jhep.2007.09.003

    authors： Dufour JF,Huber O,Kozma SC,Lu X,Toftgård R

    更新日期：2007-12-01 00:00:00

  • Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

    abstract：BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.03.030

    authors： Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

    更新日期：2011-12-01 00:00:00

  • Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).

    abstract：BACKGROUND & AIMS:FibroTest™ (FT) and Transient Elastography (TE) have been validated as non-invasive markers of METAVIR fibrosis stages from F0 to F4 using biopsy, and as prognostic markers of liver related mortality in patients with chronic hepatitis C. The aim was to extend the validation of FT and TE as markers of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.11.016

    authors： Poynard T,Vergniol J,Ngo Y,Foucher J,Munteanu M,Merrouche W,Colombo M,Thibault V,Schiff E,Brass CA,Albrecht JK,Rudler M,Deckmyn O,Lebray P,Thabut D,Ratziu V,de Ledinghen V,FibroFrance Study Group.,Epic3 Study Group.,

    更新日期：2014-04-01 00:00:00

  • The classification and biological functions of the interferons. A review.

    abstract：:There are three main types of interferon, now designated alpha, beta and gamma. Human interferons-alpha exist as many subtypes, probably more than 26. These are chemically quite closely related, but each has a unique chemical composition and biological properties. Preparations of interferon-alpha derived from stimulat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(86)80115-5

    authors： Finter NB

    更新日期：1986-01-01 00:00:00

  • The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver.

    abstract：BACKGROUND/AIMS:Liver growth factor (LGF) is a hepatic mitogen, however, the hepatic stimulation pathway remains to be characterized. The aim of this study was to determine whether tumor necrosis factor alpha (TNF-alpha) stimulation constitutes a step in the mitogenic pathway of LGF. METHODS:Rats were injected with 4....

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00030-8

    authors： Díaz-Gil JJ,Majano PL,López-Cabrera M,Sánchez-López V,Rúa C,Machín C,Trilla C,García-Cañero R,Moreno-Otero R

    更新日期：2003-05-01 00:00:00

  • The impact of organ dysfunction in cirrhosis: survival at a cost?

    abstract：BACKGROUND & AIMS:The incidence of cirrhosis and subsequent development of organ dysfunction (OD) requiring intensive care unit (ICU) support is rising. Historically, critically ill cirrhotics are perceived as having poor prognosis and substantial cost of care. METHODS:The aim was to prospectively analyse resource uti...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.12.014

    authors： Shawcross DL,Austin MJ,Abeles RD,McPhail MJW,Yeoman AD,Taylor NJ,Portal AJ,Jamil K,Auzinger G,Sizer E,Bernal W,Wendon JA

    更新日期：2012-05-01 00:00:00

  • Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study.

    abstract：BACKGROUND & AIMS:TMC435 is an investigational, once-daily, oral NS3/4A protease inhibitor currently in phase III development for the treatment of hepatitis C virus (HCV) infection. Phase I and II studies in patients infected with HCV genotype 1 have demonstrated that TMC435 is generally well tolerated, has a pharmacok...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2011.12.033

    authors： Moreno C,Berg T,Tanwandee T,Thongsawat S,Van Vlierberghe H,Zeuzem S,Lenz O,Peeters M,Sekar V,De Smedt G

    更新日期：2012-06-01 00:00:00

  • Taurocholate transport by liver plasma membrane vesicles is not altered in cirrhotic rats.

    abstract：:Recently, we have shown that taurocholate transport is impaired in hepatocytes isolated from CCl4 cirrhotic rats. Na+,K+-ATPase activity depends on the lipid composition of the surrounding membrane. Therefore, we performed this study in order to detect differences in plasma membrane composition and membrane functions ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(89)90068-8

    authors： Krähenbühl S,Meier-Abt PJ,Reichen J

    更新日期：1989-07-01 00:00:00

  • Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis.

    abstract：BACKGROUND & AIMS:Primary biliary cirrhosis (PBC) is believed to result from the interaction of genetic and environmental factors. The controlled studies aiming to assess risk factors for PBC are still limited. Our aim was to identify risk factors and co-morbidities associated with PBC in a large monocentric cohort. M...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.02.019

    authors： Corpechot C,Chrétien Y,Chazouillères O,Poupon R

    更新日期：2010-07-01 00:00:00

  • HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis.

    abstract：BACKGROUND/AIMS:Type 2 autoimmune hepatitis (AIH) is characterized by the presence of anti-liver kidney microsome (anti-LKM-1) and/or anti-liver cytosol type 1 (anti-LC1) autoantibodies. However, the correlation between these autoantibodies and the genetic background has not been studied. METHODS:Frequencies of HLA cl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.07.034

    authors： Djilali-Saiah I,Fakhfakh A,Louafi H,Caillat-Zucman S,Debray D,Alvarez F

    更新日期：2006-12-01 00:00:00

  • Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.

    abstract：BACKGROUND & AIMS:To evaluate the hypothesis that increasing T cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a programmed death receptor 1 (PD-1) inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally suppressed patients with HBV e ant...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.06.028

    authors： Gane E,Verdon DJ,Brooks AE,Gaggar A,Nguyen AH,Subramanian GM,Schwabe C,Dunbar PR

    更新日期：2019-11-01 00:00:00