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Delta infection in the Naples area. Epidemiologic and clinical significance.

Abstract：

:To define the epidemiologic and clinical significance of delta infection in the Naples area, we sought anti-delta antibodies in all cases of HBV-associated liver diseases, hospitalized in our department during 1983 (234 acute hepatitis, 9 of which fulminant; 51 chronic hepatitis; 32 cirrhosis; 19 hepatocarcinomas) and in randomly selected acute hepatitis over the previous 6 years. Delta agent in acute forms and IgM anti-HBc in delta-positive acute forms were also tested. The acute cases were controlled for at least 9 months after dismissal. Delta infection showed a high prevalence in the Naples area (20% of all acute cases in 1983; similar prevalences in previous years; high rate of coinfections, 81%; no peculiar modalities of circulation) and a high pathogenicity, as proved by the greater prevalence in fulminant cases (66.7%) and severe chronic forms. Moreover superinfection appears a more dangerous event than coinfection as regards the diseases becoming chronic (77.8% vs 2.5%).

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Amoroso P,Giorgio A,Fico P,Lettieri G,de Stefano G,Scala V,Pesce G,Pierri P,Pempinello R,Finelli L

doi

10.1016/s0168-8278(86)80003-4

subject

Has Abstract,Author List Incomplete

pub_date

1986-01-01 00:00:00

pages

11-8

issue

1

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(86)80003-4

journal_volume

2

pub_type

杂志文章

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