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Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study.

Abstract：

BACKGROUND/AIMS:Treatment of hepatorenal syndrome (HRS) is based on vasoconstrictors. Terlipressin is the one with the soundest evidence. Noradrenalin has been suggested as an effective alternative. The current study was aimed at assessing the efficacy and safety of noradrenalin vs terlipressin in patients with HRS. METHODS:Twenty-two consecutive cirrhotic patients with HRS (9 with HRS type 1; 13 with HRS type 2) were included. Patients were randomly assigned to be treated with noradrenalin (0.1-0.7 microg/kg/min) and albumin (10 patients) or with terlipressin (1-2 mg/4h) and albumin (12 patients). Treatment was administered until HRS reversal or for a maximum of two weeks. Patients were followed-up until liver transplantation or death. RESULTS:Reversal of HRS was observed in 7 of the 10 patients (70%) treated with noradrenalin and in 10 of the 12 patients (83%) treated with terlipressin, p=ns. Treatment led in both groups to a significant improvement in renal and circulatory function. No patient developed signs of myocardial ischemia. CONCLUSIONS:Data from this unblinded, pilot study suggest that noradrenalin is as effective and safe as terlipressin in patients with HRS. These results would support the use of noradrenalin, a cheap and widely available drug, in the management of these patients.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Alessandria C,Ottobrelli A,Debernardi-Venon W,Todros L,Cerenzia MT,Martini S,Balzola F,Morgando A,Rizzetto M,Marzano A

doi

10.1016/j.jhep.2007.04.010

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

499-505

issue

4

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(07)00287-5

journal_volume

47

pub_type

杂志文章,随机对照试验

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