Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.

abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

journal_title：Journal of hepatology

authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIMS:We developed a bioartificial liver (BAL) based on a direct hemoperfusion typed nonwoven fabric bioreactor containing porcine hepatocytes. In this study, the efficacy of our BAL was evaluated with a pig fulminant hepatic failure (FHF) model. METHODS:FHF was induced with intravenous administration of D-g...

journal_title：Journal of hepatology

authors： Li LJ,Du WB,Zhang YM,Li J,Pan XP,Chen JJ,Cao HC,Chen Y,Chen YM

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND/AIMS:Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro in pure cultures of these cells. METHODS:We investigated whether Kupffer cells in the liver slice are still responsive to an inflammatory stimulus of lipopolysacch...

journal_title：Journal of hepatology

authors： Olinga P,Merema MT,de Jager MH,Derks F,Melgert BN,Moshage H,Slooff MJ,Meijer DK,Poelstra K,Groothuis GM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

journal_title：Journal of hepatology

authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

更新日期：2004-02-01 00:00:00

abstract：:Hepatitis C infection is common in patients undergoing liver transplantation. Few studies have focused on the prevalence and epidemiology of hepatitis C infection among liver transplant recipients since the implementation of donor screening for antibodies against the hepatitis C virus (anti-HCV). Using reverse transcr...

journal_title：Journal of hepatology

authors： Weinstein JS,Poterucha JJ,Zein N,Wiesner RH,Persing DH,Rakela J

更新日期：1995-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared the safety, tolerabi...

journal_title：Journal of hepatology

authors： Shouval D,Ashur Y,Adler R,Lewis JA,Miller W,Kuter B,Brown L,Nalin DR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Reactive oxygen species (ROS), such as H2O2, are implicated in normal and pathological liver function. However, due to the lack of suitable in vivo models of ROS generation the (patho) physiological relevance of H2O2 remains controversial. METHODS:We established a novel model of sustained hepatic H2O2 ...

journal_title：Journal of hepatology

authors： Rost D,Welker A,Welker J,Millonig G,Berger I,Autschbach F,Schuppan D,Mueller S

更新日期：2007-03-01 00:00:00

abstract：AIM/METHODS:To elucidate the metabolic effect of interferon alpha, the following tests were performed on 14 patients with chronic active hepatitis C before and after interferon therapy (6 million units/day for 2 weeks): (1) oral glucose tolerance tests to measure insulin secretion; (2) euglycemic hyperinsulinemic clamp...

journal_title：Journal of hepatology

authors： Imano E,Kanda T,Ishigami Y,Kubota M,Ikeda M,Matsuhisa M,Kawamori R,Yamasaki Y

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis B virus can cause serious problems in individuals undergoing organ transplantation. The aim of this study was to evaluate the hepatic events among HBs-Ag positive recipients and HBs-Ag negative recipients who received products from hepatitis B virus carriers. METHODS:A total of 151 patients r...

journal_title：Journal of hepatology

authors： Ustün C,Idilman R,Gürman G,Ozcan M,Akyol G,Akan H,Ilhan O,Beksaç M,Uysal A,Konuk N,Karayalçin S,Poyraz A,Van Thiel D,Koç H

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND & AIMS:The primary aim of this study was to compare the rate of global radiofrequency ablation (RFA) failure between monopolar RFA (MonoRFA) vs. no-touch multi-bipolar RFA (NTmbpRFA) for small hepatocellular carcinoma (HCC) ⩽5cm in cirrhotic patients. METHODS:A total of 362 cirrhotic patients were included ...

journal_title：Journal of hepatology

authors： Hocquelet A,Aubé C,Rode A,Cartier V,Sutter O,Manichon AF,Boursier J,N'kontchou G,Merle P,Blanc JF,Trillaud H,Seror O

更新日期：2017-01-01 00:00:00

abstract：:Serotonin or 5-hydroxytryptamine (5-HT) is known to regulate several key aspects of liver biology and these functions include hepatic blood flow, innervation and wound healing. Given the importance of these functions it is surprising that relatively little time has been dedicated to studying the precise function and m...

journal_title：Journal of hepatology

authors： Ruddell RG,Mann DA,Ramm GA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND/AIMS:Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder characterized by reduced plasma levels of low-density lipoproteins. It can be caused by mutations in the gene encoding apolipoprotein B-100 (apo B), leading to the formation of truncated apo Bs which have a reduced capacity to export lipi...

journal_title：Journal of hepatology

authors： Tarugi P,Lonardo A,Ballarini G,Erspamer L,Tondelli E,Bertolini S,Calandra S

更新日期：2000-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and its burden is expected to increase further in the next years. In spite of the advances of classical therapies, such as surgery, transplantation, use of radiofrequency and transarterial embolization, the prognosis of this neoplasm ...

journal_title：Journal of hepatology

authors： Giordano S,Columbano A

更新日期：2014-02-01 00:00:00

abstract：:HCV is the principal etiologic agent of post-transfusion (PTH) hepatitis. The incidence and course of HCV hepatitis in liver transplant recipients is not well established. To resolve this information deficit, all records of recipients of single liver transplant (OLTx) between March 1986 and March 1990 at the Universit...

journal_title：Journal of hepatology

authors： Shah G,Demetris AJ,Irish W,Scheffel J,Mimms L,Van Thiel DH

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND/AIMS:Graft reperfusion in liver transplantation is usually performed by initial portal reperfusion (IPR) and delayed rearterialization. Its influence on graft microcirculation is unknown. This study aimed to assess sinusoidal perfusion in dependence to this reperfusion technique during human living-donor liv...

journal_title：Journal of hepatology

authors： Puhl G,Schaser KD,Pust D,Köhler K,Vollmar B,Menger MD,Neuhaus P,Settmacher U

更新日期：2004-08-01 00:00:00

abstract：:Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

journal_title：Journal of hepatology

authors： Graf J,Häussinger D

更新日期：1996-01-01 00:00:00

abstract：:The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...

journal_title：Journal of hepatology

authors： Reyes GR,Huang CC,Yarbough PO,Tam AW

更新日期：1991-01-01 00:00:00

abstract：:We have studied the roles of immunoprophylaxis, patient selection policy and coexistent hepatitis D virus infection in the outcome of 56 HBsAg-positive elective liver transplant recipients. Twenty-nine unselected patients not treated with immunoprophylaxis formed group 1 and were compared to a recent consecutive serie...

journal_title：Journal of hepatology

authors： Devlin J,Smith HM,O'Grady JG,Portmann B,Tan KC,Williams R

更新日期：1994-08-01 00:00:00

abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

journal_title：Journal of hepatology

authors： Krowka MJ,Wiesner RH,Heimbach JK

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIMS:The glycosphingolipid alpha-galactosylceramide has been shown to activate invariant natural killer T cells when presented in the context of CD1d and induces powerful antiviral immune responses via the production of inflammatory cytokines. The aim of this study was to investigate the safety and the antiv...

journal_title：Journal of hepatology

authors： Veldt BJ,van der Vliet HJ,von Blomberg BM,van Vlierberghe H,Gerken G,Nishi N,Hayashi K,Scheper RJ,de Knegt RJ,van den Eertwegh AJ,Janssen HL,van Nieuwkerk CM

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

journal_title：Journal of hepatology

authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:To review our experience of thrombolytic therapy in patients with acute Budd Chiari syndrome (BCS). METHODS:Records of 10 patients with BCS, treated by thrombolysis over a 12-year period were retrospectively analysed for demographics, clinical presentation/duration, primary disease, thrombolytic regime...

journal_title：Journal of hepatology

authors： Sharma S,Texeira A,Texeira P,Elias E,Wilde J,Olliff SP

更新日期：2004-01-01 00:00:00

abstract：:In an attempt to evaluate the prevalence, kinetics and impact of HCV infection in renal transplantation, we analyzed 140 kidney recipients according to the histopathological status of the liver. Thirty-three HBsAg-negative patients had chronic active hepatitis, 73 HBsAg-negative patients had a normal liver, 21 HBsAg-n...

journal_title：Journal of hepatology

authors： Pol S,Legendre C,Saltiel C,Carnot F,Bréchot C,Berthelot P,Mattlinger B,Kreis H

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory region and characterized its transcriptional regulation by the NFκB-dependent inflammatory pathways. METHODS:Mature miRNA expre...

journal_title：Journal of hepatology

authors： Scisciani C,Vossio S,Guerrieri F,Schinzari V,De Iaco R,D'Onorio de Meo P,Cervello M,Montalto G,Pollicino T,Raimondo G,Levrero M,Pediconi N

更新日期：2012-04-01 00:00:00

abstract：:Treatment of hepatic fibrosis by simple and inexpensive therapies is a new challenge for the near future. Hepatic fibrosis which may lead to cirrhosis, is indeed associated with most chronic liver diseases and affects millions of people. During the last decade, major breakthroughs have been accomplished in the field o...

journal_title：Journal of hepatology

authors： Clément B,Loréal O,Levavasseur F,Guillouzo A

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C patients infected by genotype 1 are the least responsive to combination therapy and therefore monitoring response is important in identifying non-responders quickly, permitting therapy discontinuation and avoiding side effects and costs. We examined the usefulness of measuring total ...

journal_title：Journal of hepatology

authors： Buti M,Mendez C,Schaper M,Sauleda S,Valdes A,Rodriguez-Frias F,Jardi R,Esteban R

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIMS:While combination of peginterferon-alpha (PEG-IFN) and ribavirin (RBV) therapy is the current standard of care for chronic hepatitis C (CHC), only 44-51% of genotype-1 patients achieve a sustained virological response (SVR), and both agents produce treatment-limiting toxicities. In the hepatitis C virus...

journal_title：Journal of hepatology

authors： Marcellin P,Horsmans Y,Nevens F,Grange JD,Bronowicki JP,Vetter D,Purdy S,Garg V,Bengtsson L,McNair L,Alam J

更新日期：2007-10-01 00:00:00

abstract：:To study experimentally the protective effect of post-exposure prophylaxis against hepatitis B (HB), a special preparation of hepatitis B immune globulin (HBIG) was injected intravenously (i.v.) into three chimpanzees simultaneously with, or at different time intervals after, intravenous injection of a titred inoculum...

journal_title：Journal of hepatology

authors： Wahl M,Iwarson S,Snoy P,Gerety RJ

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor c...

journal_title：Journal of hepatology

authors： Ceni E,Mello T,Polvani S,Vasseur-Cognet M,Tarocchi M,Tempesti S,Cavalieri D,Beltrame L,Marroncini G,Pinzani M,Milani S,Galli A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND & AIMS:The MELD score predicts short-term mortality in patients with cirrhosis; however, some patients with low scores develop complications and die unexpectedly. Consequently, we evaluated the diagnostic accuracy of the methacetin breath test (MBT), an assay of liver metabolic function, and the MELD score, ...

journal_title：Journal of hepatology

authors： Stravitz RT,Reuben A,Mizrahi M,Lalazar G,Brown K,Gordon SC,Ilan Y,Sanyal A

更新日期：2015-12-01 00:00:00