The classification and biological functions of the interferons. A review.

abstract：:A technique is described for the isolation and culture of Kupffer cells (Kc) from needle and surgical liver biopsies of humans and rats. The isolation procedure is based on puncture perfusion of the specimen with collagenase and pronase, and subsequent gradient centrifugation. The ultrastructure of the cultured cells ...

journal_title：Journal of hepatology

authors： Van Bossuyt H,Wisse E

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND/AIMS:Health-related quality of life (HRQoL) is impaired in patients with chronic hepatitis C. We investigated HRQoL and fatigue in patients with chronic hepatitis C virus (HCV) infection in relation to the degree of fibrosis and inflammation, and controlled for the influence of relevant demographic and medic...

journal_title：Journal of hepatology

authors： Teuber G,Schäfer A,Rimpel J,Paul K,Keicher C,Scheurlen M,Zeuzem S,Kraus MR

更新日期：2008-12-01 00:00:00

abstract：:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human...

journal_title：Journal of hepatology

authors： Rasche A,Sander AL,Corman VM,Drexler JF

更新日期：2019-03-01 00:00:00

abstract：:The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks. The clinical response to hematin occurred unifo...

journal_title：Journal of hepatology

authors： Bissell DM

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinoma (CCA) carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. While these tumors commonly express PD-1 and PD-L1, the response to immune checkpoint inhibitors (ICI) is poor. Stimulating antigen-presenting cells includi...

journal_title：Journal of hepatology

authors： Diggs LP,Ruf B,Ma C,Heinrich B,Cui L,Zhang Q,McVey JC,Wabitsch S,Heinrich S,Rosato U,Lai W,Subramanyam V,Longerich T,Loosen SH,Luedde T,Neumann UP,Desar S,Kleiner D,Gores G,Wang XW,Greten TF

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND & AIMS:p53 mutations occur frequently in human HCC. Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these changes together initiate HCC and can be targeted as a potential therapeutic strategy. METHODS:We generated mouse models ...

journal_title：Journal of hepatology

authors： Luo YD,Fang L,Yu HQ,Zhang J,Lin XT,Liu XY,Wu D,Li GX,Huang D,Zhang YJ,Chen S,Jiang Y,Shuai L,He Y,Zhang LD,Bie P,Xie CM

更新日期：2021-01-01 00:00:00

abstract：:The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers with chronic hepatitis...

journal_title：Journal of hepatology

authors： Pignatelli M,Waters J,Lever A,Iwarson S,Gerety R,Thomas HC

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND/AIMS:Gene therapy for inherited liver diseases requires permanent expression of the therapeutic gene. However, in vivo liver transduction with retroviral vectors triggers an immune elimination of transduced hepatocytes. Here we investigated whether immune response could be prevented by treatment with compoun...

journal_title：Journal of hepatology

authors： Puppi J,Guillonneau C,Pichard V,Bellodi-Privato M,Cuturi MC,Anegon I,Ferry N

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that hepatic natural killer (NK) cells, also called pit cells, have a higher cytotoxicity against certain tumor cells and have a higher expression of the cell adhesion molecule CD11a as compared with blood NK cells. We further investigated the involvement of the adhesion mole...

journal_title：Journal of hepatology

authors： Luo D,Vermijlen D,Vanderkerken K,Kuppen PJ,Seynaeve C,Eddouks M,Baekeland M,Wisse E

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIMS:Intestinal microflora plays an important role in the pathogenesis of neonatal jaundice by inhibiting enterosystemic circulation of bilirubin. The present study aimed to investigate the influence of intestinal microflora on serum bilirubin levels in hyperbilirubinemic Gunn rats. METHODS:After a baseline...

journal_title：Journal of hepatology

authors： Vítek L,Zelenka J,Zadinová M,Malina J

更新日期：2005-02-01 00:00:00

abstract：:Fulminant hepatic failure has a high mortality rate despite intensive medical treatment. Urgent hepatic transplantation was considered over a 3 year period in 26 (36%) of 73 patients with the worst prognostic features of fulminant hepatic failure. The criteria for patient selection were based on the duration of advanc...

journal_title：Journal of hepatology

authors： Vickers C,Neuberger J,Buckels J,McMaster P,Elias E

更新日期：1988-10-01 00:00:00

abstract：:We have studied the roles of immunoprophylaxis, patient selection policy and coexistent hepatitis D virus infection in the outcome of 56 HBsAg-positive elective liver transplant recipients. Twenty-nine unselected patients not treated with immunoprophylaxis formed group 1 and were compared to a recent consecutive serie...

journal_title：Journal of hepatology

authors： Devlin J,Smith HM,O'Grady JG,Portmann B,Tan KC,Williams R

更新日期：1994-08-01 00:00:00

abstract：:Endoscopic ultrasonography was performed in 80 cirrhotic patients and 50 control subjects. The aim of the study was to describe and classify the vascular abnormalities of the gastric wall as observed on echoendoscopy in cirrhotic patients and to compare the data with endoscopy. The size of gastric varices was classifi...

journal_title：Journal of hepatology

authors： Boustière C,Dumas O,Jouffre C,Letard JC,Patouillard B,Etaix JP,Barthélémy C,Audigier JC

更新日期：1993-09-01 00:00:00

abstract：:Recently antibodies to hepatitis C virus were detected in sera of chronic active hepatitis patients, with anti-smooth muscle autoantibodies or with anti-liver/kidney microsomal type 1 autoantibodies. As the latter were used to differentiate autoimmune chronic active hepatitis from chronic non-A, non-B virus hepatitis,...

journal_title：Journal of hepatology

authors： Abuaf N,Lunel F,Giral P,Borotto E,Laperche S,Poupon R,Opolon P,Huraux JM,Homberg JC

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND/AIMS:No information is yet available about the influence of alcohol abuse on the translocation of larger molecules (Mr>1200) through the intestinal mucosa in man. The present study aimed to determine the intestinal permeability to macromolecules in patients with chronic alcohol abuse and mild to more advance...

journal_title：Journal of hepatology

authors： Parlesak A,Schäfer C,Schütz T,Bode JC,Bode C

更新日期：2000-05-01 00:00:00

abstract：:A total of 37 patients with histologically confirmed chronic viral hepatitis B and presence of HBV-DNA and HBsAg in the serum were treated in a randomized, prospectively controlled multicenter trial either with recombinant IFN alpha-2b alone or a combination of IFN alpha-2b and recombinant IL-2. Twenty-two patients fr...

journal_title：Journal of hepatology

authors： Bruch HR,Korn A,Klein H,Markus R,Malmus K,Baumgarten R,Müller R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

journal_title：Journal of hepatology

authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND/AIMS:Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differ...

journal_title：Journal of hepatology

authors： Tsai YH,Kuang WF,Lu TY,Kao JH,Lai MY,Liu CJ,Chen PJ,Hwang LH

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Chronic liver failure resulting from hepatitis C virus infection often necessitates orthotopic liver transplantation. Recurrence of hepatitis C virus infection after transplantation is inevitable, and the infection is usually severe. Interferon and ribavirin have both been used to treat hepatitis C virus inf...

journal_title：Journal of hepatology

authors： Bizollon T,Ducerf C,Trépo C

更新日期：1995-01-01 00:00:00

abstract：:Infection with the hepatitis C virus (HCV) is the major cause of nonA-nonB hepatitis worldwide. Although this virus cannot be cultivated in vitro, several of its key features have been elucidated in the past few years. The viral genome is a positive-sense, single-stranded, 9.6 kb long RNA molecule. The viral genome is...

journal_title：Journal of hepatology

authors： De Francesco R

更新日期：1999-01-01 00:00:00

abstract：:To evaluate the efficacy of recombinant interferon alpha-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected recombinant interferon alpha-2...

journal_title：Journal of hepatology

authors： Hwang SJ,Lee SD,Chan CY,Lu RH,Lo KJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and develop...

journal_title：Journal of hepatology

authors： Dong LQ,Peng LH,Ma LJ,Liu DB,Zhang S,Luo SZ,Rao JH,Zhu HW,Yang SX,Xi SJ,Chen M,Xie FF,Li FQ,Li WH,Ye C,Lin LY,Wang YJ,Wang XY,Gao DM,Zhou H,Yang HM,Wang J,Zhu SD,Wang XD,Cao Y,Zhou J,Fan J,Wu K,Gao

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND/AIMS:5-Aminolevulinic acid (ALA), a precursor of porphyrins is used for photodynamic diagnosis and therapy within topical or systemic applications. A potential toxic effect on the human liver is of major interest and therefore we investigated the impact of a repeated application of ALA without illumination o...

journal_title：Journal of hepatology

authors： Weiss TS,Pahernik S,Scheruebl I,Jauch KW,Thasler WE

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHOD...

journal_title：Journal of hepatology

authors： Bozic M,Guzmán C,Benet M,Sánchez-Campos S,García-Monzón C,Gari E,Gatius S,Valdivielso JM,Jover R

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) is characterised by the presence of organ failure in patients with decompensated cirrhosis and is associated with high short-term mortality. However, there are limited data on the prevalence and short-term outcomes of ACLF in patients with cirrhosis seen in the US...

journal_title：Journal of hepatology

authors： Hernaez R,Kramer JR,Liu Y,Tansel A,Natarajan Y,Hussain KB,Ginès P,Solà E,Moreau R,Gerbes A,El-Serag HB,Kanwal F

更新日期：2019-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) cDNA sequence in the nonstructural region NS3 was amplified from the serum of 66% French non-A, non-B hepatitis patients by the nested polymerase chain reaction. A 407 base-pair sequence was determined from four such cases, which revealed the presence of two different virus genotypes F1 (three ...

journal_title：Journal of hepatology

authors： Li JS,Tong SP,Vitvitski L,Lepot D,Trépo C

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. METHODS:31 patients with cirrhosis (Child classes A/B/C=8/14/9) received an intr...

journal_title：Journal of hepatology

authors： Brinch K,Møller S,Bendtsen F,Becker U,Henriksen JH

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis C virus (HCV) infection and cirrhosis have a higher risk for liver-related complications and have historically been more difficult to cure than patients without cirrhosis. We evaluated the safety and efficacy of ombitasvir/paritaprevir/ritonavir and dasabuvir, without r...

journal_title：Journal of hepatology

authors： Feld JJ,Moreno C,Trinh R,Tam E,Bourgeois S,Horsmans Y,Elkhashab M,Bernstein DE,Younes Z,Reindollar RW,Larsen L,Fu B,Howieson K,Polepally AR,Pangerl A,Shulman NS,Poordad F

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:The toll-like receptor 9 (TLR9) agonist IMO-2125 is currently evaluated in clinical trials for chronic hepatitis C therapy. The aim of this study was to investigate the in vivo mode of action of a closely related compound, referred to as immunomodulatory oligonucleotide (IMO). METHODS:We analyzed the...

journal_title：Journal of hepatology

authors： Makowska Z,Blumer T,Duong FH,La Monica N,Kandimalla ER,Heim MH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND/AIM:Smooth muscle antibodies and antinuclear antibodies characterize type 1 autoimmune hepatitis. Our aim was to correlate the appearance and disappearance of these autoantibodies with clinical and histological events. METHODS:One hundred and seven patients were evaluated successively over 128+/-9 months. A...

journal_title：Journal of hepatology

authors： Czaja AJ

更新日期：1999-03-01 00:00:00