Non-organ specific autoantibodies associated with chronic C virus hepatitis.

abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. Increasing recognition of the importance of NAFLD and its association with the features of the metabolic syndrome has stimulated an interest in its putative role in the development and progression of chronic kidney dise...

journal_title：Journal of hepatology

authors： Targher G,Chonchol M,Zoppini G,Abaterusso C,Bonora E

更新日期：2011-05-01 00:00:00

abstract：:This review will highlight some of the important recent trends in liver transplantation. When possible, we will compare and contrast these trends across various regions of the world, in an effort to improve global consensus and better recognition of emerging data. ...

journal_title：Journal of hepatology

authors： Burra P,Freeman R

更新日期：2012-01-01 00:00:00

abstract：:A monoclonal antibody, designated K-PLC1, has been produced to a tumour-associated antigen on the cell membrane of the PLC/PRF/5 cell line. Using an indirect immunofluorescence technique this antibody produced membrane staining of three hepatocellular carcinoma (HCC) cell lines and it has positively stained 10 of 11 h...

journal_title：Journal of hepatology

authors： Dunk AA,Brown D,Weidmann K,Thomas HC

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C. METHODS:HIV/HCV co-infected study participants (n=179) were recruited into a prospective cohort and underwent dual-energy X-ray absorptiometry (DXA) within 1 year of a liver...

journal_title：Journal of hepatology

authors： El-Maouche D,Mehta SH,Sutcliffe C,Higgins Y,Torbenson MS,Moore RD,Thomas DL,Sulkowski MS,Brown TT

更新日期：2011-10-01 00:00:00

abstract：:Hepatitis C infection is common in patients undergoing liver transplantation. Few studies have focused on the prevalence and epidemiology of hepatitis C infection among liver transplant recipients since the implementation of donor screening for antibodies against the hepatitis C virus (anti-HCV). Using reverse transcr...

journal_title：Journal of hepatology

authors： Weinstein JS,Poterucha JJ,Zein N,Wiesner RH,Persing DH,Rakela J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND/AIMS:Suspensions of isolated hepatocytes are a valuable tool to study liver functions. For optimal use of the isolated hepatocytes, methods are needed to preserve the hepatocytes while maintaining their viability, metabolic and transport functions. Until now, little has been known about the maintenance of th...

journal_title：Journal of hepatology

authors： Olinga P,Merema M,Slooff MJ,Meijer DK,Groothuis GM

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND/AIMS:Vascular endothelial growth factor (VEGF) is an angiogenic factor with a growth-promoting effect that is thought to be restricted to vascular endothelial cells. Its essential role during liver regeneration has yet to be determined. The aim of this study was to document the effect of exogenous VEGF admin...

journal_title：Journal of hepatology

authors： Assy N,Spira G,Paizi M,Shenkar L,Kraizer Y,Cohen T,Neufeld G,Dabbah B,Enat R,Baruch Y

更新日期：1999-05-01 00:00:00

abstract：:Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

journal_title：Journal of hepatology

authors： Thietart S,Rautou PE

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND/AIMS:The underlying mechanisms of steatosis, the first stage of non-alcoholic fatty liver disease (NAFLD) that is characterized by the accumulation of lipids in hepatocytes, remain unclear. Our study aimed to investigate the hypothesis that cigarette smoke is known to change circulating lipid profiles and th...

journal_title：Journal of hepatology

authors： Yuan H,Shyy JY,Martins-Green M

更新日期：2009-09-01 00:00:00

abstract：:A young female, who had been in excellent health and had used third-generation oral contraceptives, was admitted to hospital because of abdominal pain and ascites. Budd-Chiari syndrome (BCS) was diagnosed by radiographic and histological examination. Tests for myeloproliferative disease, deficiency of coagulation inhi...

journal_title：Journal of hepatology

authors： Minnema MC,Janssen HL,Niermeijer P,de Man RA

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND & AIMS:Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS:We used wild type mice and m...

journal_title：Journal of hepatology

authors： Ducheix S,Montagner A,Polizzi A,Lasserre F,Marmugi A,Bertrand-Michel J,Podechard N,Al Saati T,Chétiveaux M,Baron S,Boué J,Dietrich G,Mselli-Lakhal L,Costet P,Lobaccaro JM,Pineau T,Theodorou V,Postic C,Martin PG,Guil

更新日期：2013-05-01 00:00:00

abstract：:Our understanding of the process whereby replicating Hepatitis B virus is eradicated has been substantially modified by the development of highly sensitive assays of viral replication, such as the detection of HBV-DNA in serum. The implications of these developments on our therapeutic approach in terms of both timing ...

journal_title：Journal of hepatology

authors： Williams R,Alexander GJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

journal_title：Journal of hepatology

authors： Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND/AIMS:We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma. METHODS:We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones. RESULTS:Freq...

journal_title：Journal of hepatology

authors： Katoh H,Shibata T,Kokubu A,Ojima H,Loukopoulos P,Kanai Y,Kosuge T,Fukayama M,Kondo T,Sakamoto M,Hosoda F,Ohki M,Imoto I,Inazawa J,Hirohashi S

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about EBV-associated intrahepatic cholangiocarcinoma (EBVaICC) due to its rarity. We aimed to comprehensively investigate the clinicopathology, tumor immune microenvironment (TIME) and genomic landscape of this entity in southern China. METHODS:We evaluated 303 ICCs using in situ hy...

journal_title：Journal of hepatology

authors： Huang YH,Zhang CZ,Huang QS,Yeong J,Wang F,Yang X,He YF,Zhang XL,Zhang H,Chen SL,Zheng YL,Deng R,Lin CS,Yang MM,Li Y,Jiang C,Kin-Wah Lee T,Ma S,Zeng MS,Yun JP

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND & AIMS:We applied advanced magnetic resonance imaging and Voxed based Morphometry analysis to assess brain tissue density in patients with cirrhosis. METHODS:Forty eight patients with cirrhosis without overt hepatic encephalopathy (17 Child A, 13 Child B, and 18 Child C) and 51 healthy subjects were matched...

journal_title：Journal of hepatology

authors： Guevara M,Baccaro ME,Gómez-Ansón B,Frisoni G,Testa C,Torre A,Molinuevo JL,Rami L,Pereira G,Sotil EU,Córdoba J,Arroyo V,Ginès P

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholic patients develop severe liver disease with fibrosis progressing to cirrhosis. It is of practical importance to determine whether some markers can predict progression of liver fibrosis. METHODS:We used a baboon model that mimics human alcoholic liver disease. Cytokeratin 7 and 19 expre...

journal_title：Journal of hepatology

authors： Ren C,Paronetto F,Mak KM,Leo MA,Lieber CS

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND/AIMS:Suppressor of cytokine signaling (SOCS)-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis. We studied the effect of the core protein of hepatitis C virus (...

journal_title：Journal of hepatology

authors： Miyoshi H,Fujie H,Shintani Y,Tsutsumi T,Shinzawa S,Makuuchi M,Kokudo N,Matsuura Y,Suzuki T,Miyamura T,Moriya K,Koike K

更新日期：2005-11-01 00:00:00

abstract：:A quantitative immunohistochemical study of Kupffer cells in liver biopsies from alcoholics was carried out. Two markers were compared, lysozyme and an antimacrophage monoclonal antibody EMB/11. The results showed that there is no significant reduction in Kupffer cell numbers in acute and chronic alcoholic liver disea...

journal_title：Journal of hepatology

authors： Kelly PM,Heryet AR,McGee JO

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

journal_title：Journal of hepatology

authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

更新日期：2007-02-01 00:00:00

abstract：:Hydroxyethyl starch (HES) has gained wide clinical acceptance as a colloidal plasma substitute. We were able to study the liver biopsies of two patients with renal failure who developed ascites after repeated infusions of HES. All types of liver cells displayed massive accumulation of HES with the morphologic resembla...

journal_title：Journal of hepatology

authors： Dienes HP,Gerharz CD,Wagner R,Weber M,John HD

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Recently, a novel DNA virus was isolated from the serum of a patient with post-transfusion non-A-G hepatitis and named TT virus. The aim of this study was to determine the prevalence and clinical characteristics of TT virus infection in patients with sporadic acute hepatitis of unknown etiology. METHOD...

journal_title：Journal of hepatology

authors： Parquet MC,Yatsuhashi H,Koga M,Inoue O,Matsumoto T,Hamada R,Igarashi A,Yano M

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND/AIMS:Indomethacin has been shown to have adverse effects on renal function in patients with well-compensated alcoholic cirrhosis. The aim of this study was to determine whether an oral prostaglandin E1 analogue, misoprostol, could prevent this indomethacin-induced renal dysfunction. METHODS:Six patients wit...

journal_title：Journal of hepatology

authors： Wong F,Massie D,Hsu P,Dudley F

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is n...

journal_title：Journal of hepatology

authors： Peiseler M,Sebode M,Franke B,Wortmann F,Schwinge D,Quaas A,Baron U,Olek S,Wiegard C,Lohse AW,Weiler-Normann C,Schramm C,Herkel J

更新日期：2012-07-01 00:00:00

abstract：:The interaction between fat-storing cells (FSCs) and Kupffer cells (KCs) in vitro has been studied in an attempt to clarify certain aspects of the pathogenesis of fibrotic process in the liver. FSCs and KCs were isolated from the livers of rats either treated with CCl4 for 6 weeks, or with vitamin A for 6 weeks or fro...

journal_title：Journal of hepatology

authors： Shiratori Y,Geerts A,Ichida T,Kawase T,Wisse E

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the clinical, biochemical and histological implications of a concomitant HGV infection in "HCV-related" chronic liver disease. METHODS:Eighty-three HCV-RNA positive patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR. RESULTS:Twenty-two (26.5%) patie...

journal_title：Journal of hepatology

authors： Francesconi R,Giostra F,Ballardini G,Manzin A,Solforosi L,Lari F,Descovich C,Ghetti S,Grassi A,Bianchi G,Zauli D,Clementi M,Bianchi FB

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular ballooning is a key finding in nonalcoholic steatohepatitis (NASH). It is conventionally defined by hemotoxylin and eosin (H&E) staining showing enlarged cells with rarefied cytoplasm and recently by changes in the cytoskeleton. Fat droplets are emerging as important organelles in cell ...

journal_title：Journal of hepatology

authors： Caldwell S,Ikura Y,Dias D,Isomoto K,Yabu A,Moskaluk C,Pramoonjago P,Simmons W,Scruggs H,Rosenbaum N,Wilkinson T,Toms P,Argo CK,Al-Osaimi AM,Redick JA

更新日期：2010-10-01 00:00:00

abstract：:The term cirrhosis-associated immune dysfunction refers to the main syndromic abnormalities of immune function, immunodeficiency and systemic inflammation that are present in cirrhosis. The course of advanced cirrhosis, regardless of its aetiology, is complicated by cirrhosis-associated immune dysfunction and this con...

journal_title：Journal of hepatology

authors： Albillos A,Lario M,Álvarez-Mon M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIMS:In chronic hepatitis C, disease progression and clinical manifestations are heterogenous. To clarify the role and interactions of viral and host factors in inducing liver cell injury, we examined the associations of several virological and metabolic variables with serum alanine aminotransferase levels. ...

journal_title：Journal of hepatology

authors： Prati D,Shiffman ML,Diago M,Gane E,Rajender Reddy K,Pockros P,Farci P,O'Brien CB,Lardelli P,Blotner S,Zeuzem S

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C patients infected by genotype 1 are the least responsive to combination therapy and therefore monitoring response is important in identifying non-responders quickly, permitting therapy discontinuation and avoiding side effects and costs. We examined the usefulness of measuring total ...

journal_title：Journal of hepatology

authors： Buti M,Mendez C,Schaper M,Sauleda S,Valdes A,Rodriguez-Frias F,Jardi R,Esteban R

更新日期：2004-03-01 00:00:00