当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Clinical implications of GBV-C/HGV infection in patients with "HCV-related" chronic hepatitis.

Clinical implications of GBV-C/HGV infection in patients with "HCV-related" chronic hepatitis.

Abstract：

BACKGROUND/AIMS:To evaluate the clinical, biochemical and histological implications of a concomitant HGV infection in "HCV-related" chronic liver disease. METHODS:Eighty-three HCV-RNA positive patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR. RESULTS:Twenty-two (26.5%) patients were found to be positive for GBV-C/HGV RNA. GBV-C/HGV+ patients differed significantly from GBV-C/HGV- ones for younger age, higher frequency of history of drug addiction, which in turn might favor coinfection with interferon-sensitive HCV genotypes (3a), and increased probability of long-term response to interferon. GBV-C/HGV infection appears to have no responsibility for specific aspects of HCV infection such as biochemical or histological cholestatic features, lymphoid follicles, symptomatic cryoglobulinemia or presence of serum autoantibodies, including LKM1. It does not worsen the HCV-related disease (ALT levels and histological activity) and does not significantly interfere with HCV infection, as explored by the number of hepatocytes positive for HCV antigens. The amount of steatosis (mean score) was shown to be higher in GBV-C/HGV+ patients. A virological follow up was performed in 17 interferon-treated GBV-C/HGV+ patients On the whole, GBV-C/HGV seems to be as sensitive to IFN treatment as HCV, but recurrence after withdrawal is more frequent. In spite of this, ALT levels often remain normal after treatment withdrawal. CONCLUSIONS:The present data suggest that GBV-C/HGV infection, apart from more marked liver steatosis, does not modify the overall picture of chronic hepatitis due to HCV infection.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Francesconi R,Giostra F,Ballardini G,Manzin A,Solforosi L,Lari F,Descovich C,Ghetti S,Grassi A,Bianchi G,Zauli D,Clementi M,Bianchi FB

doi

10.1016/s0168-8278(97)80448-5

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

1165-72

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(97)80448-5

journal_volume

26

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Decorin and actin expression and distribution in patients with chronic hepatitis C following interferon-alfa-2b treatment.

    abstract：BACKGROUND/AIMS:Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma. Interferon-alfa therapy may prevent the progression of the disease. The expressions of decorin and alfa-smooth muscle cell actin of the extracellular matrix play a central role in liver fibrosis. We set out to assess the expressions...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80104-x

    authors： Jármay K,Gallai M,Karácsony G,Ozsvár Z,Schaff Z,Lonovics J,Kovalszky I

    更新日期：2000-06-01 00:00:00

  • The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis.

    abstract：BACKGROUND/AIMS:Copper toxicosis (CT) in Bedlington terriers is an autosomal recessive disorder characterized by massive lysosomal copper accumulation in livers of affected dogs, and a defect in the biliary excretion of this metal. We propose that MURR1, the gene defective in canine CT, has a role in the regulation of ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00380-5

    authors： Klomp AE,van de Sluis B,Klomp LW,Wijmenga C

    更新日期：2003-11-01 00:00:00

  • Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study.

    abstract：BACKGROUND & AIMS:Statins are widely used to treat hypercholesterolemia. Statins may prevent hepatocellular carcinoma (HCC), but have not yet been fully studied, particularly in patients at high risk. Therefore, we investigated the risk of HCC after statin use in the whole general population and evaluated the effects o...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2017.10.018

    authors： Kim G,Jang SY,Nam CM,Kang ES

    更新日期：2018-03-01 00:00:00

  • Epidemiology of hepatitis C virus infection in an area of Southern Italy.

    abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) has been recognized as a major cause of liver disease, but little is known about its diffusion at population level. To estimate the prevalence and incidence of HCV infection and to explore potential risk factors at population level, an epidemiologic study was carried out. METHOD...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80276-0

    authors： Osella AR,Misciagna G,Leone A,Di Leo A,Fiore G

    更新日期：1997-07-01 00:00:00

  • Pulmonary contraindications, indications and MELD exceptions for liver transplantation: a contemporary view and look forward.

    abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2013.03.026

    authors： Krowka MJ,Wiesner RH,Heimbach JK

    更新日期：2013-08-01 00:00:00

  • Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C.

    abstract：BACKGROUND/AIMS:To compare carotid intima-media thickness (IMT) - an index of early atherosclerosis - among patients with non-alcoholic steatohepatitis (NASH), patients with chronic hepatitis B (HBV) or C (HCV) and control subjects. METHODS:We studied 60 consecutive patients with biopsy-proven NASH, 60 patients with H...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.01.021

    authors： Targher G,Bertolini L,Padovani R,Rodella S,Arcaro G,Day C

    更新日期：2007-06-01 00:00:00

  • Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.

    abstract：BACKGROUND/AIMS:Aberrant c-Jun N-terminal kinase (JNK) activation has been linked to hepatocellular carcinoma (HCC) in mouse models. It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC. METHODS:The JNK activati...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2008.07.037

    authors： Chang Q,Zhang Y,Beezhold KJ,Bhatia D,Zhao H,Chen J,Castranova V,Shi X,Chen F

    更新日期：2009-02-01 00:00:00

  • Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients.

    abstract：BACKGROUND/AIMS:The electroencephalogram (EEG) is frequently altered in cirrhotic patients. We, therefore, performed a study to ascertain the features and the prognosis of cirrhotic patients without current overt hepatic encephalopathy (OHE) who have EEG alterations. METHODS:A series of 296 consecutive cirrhotic patie...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00129-5

    authors： Amodio P,Del Piccolo F,Pettenò E,Mapelli D,Angeli P,Iemmolo R,Muraca M,Musto C,Gerunda G,Rizzo C,Merkel C,Gatta A

    更新日期：2001-07-01 00:00:00

  • Human serum albumin, systemic inflammation, and cirrhosis.

    abstract：:Human serum albumin (HSA) is one of the most frequent treatments in patients with decompensated cirrhosis. Prevention of paracentesis-induced circulatory dysfunction, prevention of type-1 HRS associated with bacterial infections, and treatment of type-1 hepatorenal syndrome are the main indications. In these indicatio...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2014.04.012

    authors： Arroyo V,García-Martinez R,Salvatella X

    更新日期：2014-08-01 00:00:00

  • Inherited non-alcoholic fatty liver disease and dyslipidemia due to monoallelic ABHD5 mutations.

    abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition and the most common liver disease worldwide, affecting more than one-third of the population. So far there have been no reports on mendelian inheritance in families with NAFLD. METHODS:We performed whole-exome or targeted next-ge...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.03.026

    authors： Youssefian L,Vahidnezhad H,Saeidian AH,Pajouhanfar S,Sotoudeh S,Mansouri P,Amirkashani D,Zeinali S,Levine MA,Peris K,Colombo R,Uitto J

    更新日期：2019-08-01 00:00:00

  • HIV infection increases HCV-induced hepatocyte apoptosis.

    abstract：BACKGROUND & AIMS:HCV related liver disease is one of the most important complications in persons with HIV, with accelerated fibrosis progression in coinfected persons compared to those with HCV alone. We hypothesized that HCV-HIV coinfection increases HCV related hepatocyte apoptosis and that HCV and HIV influence TRA...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.07.042

    authors： Jang JY,Shao RX,Lin W,Weinberg E,Chung WJ,Tsai WL,Zhao H,Goto K,Zhang L,Mendez-Navarro J,Jilg N,Peng LF,Brockman MA,Chung RT

    更新日期：2011-04-01 00:00:00

  • SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19.

    abstract：Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.05.002

    authors： Wang Y,Liu S,Liu H,Li W,Lin F,Jiang L,Li X,Xu P,Zhang L,Zhao L,Cao Y,Kang J,Yang J,Li L,Liu X,Li Y,Nie R,Mu J,Lu F,Zhao S,Lu J,Zhao J

    更新日期：2020-10-01 00:00:00

  • Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are perisinusoidal pericytes which have receptors for vasoactive factors, such as endothelin-1, which can regulate cell contractility in an autocrine manner. It is unknown whether human HSCs have receptors for and are able to synthesize the vasodilator peptide adrenomedulli...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00016-7

    authors： Görbig MN,Ginès P,Bataller R,Nicolás JM,Garcia-Ramallo E,Cejudo P,Sancho-Bru P,Jiménez W,Arroyo V,Rodés J

    更新日期：2001-02-01 00:00:00

  • Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency.

    abstract：BACKGROUND & AIMS:Lysosomal acid lipase deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. METHODS:Seb...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jhep.2014.06.022

    authors： Valayannopoulos V,Malinova V,Honzík T,Balwani M,Breen C,Deegan PB,Enns GM,Jones SA,Kane JP,Stock EO,Tripuraneni R,Eckert S,Schneider E,Hamilton G,Middleton MS,Sirlin C,Kessler B,Bourdon C,Boyadjiev SA,Sharma R,Twe

    更新日期：2014-11-01 00:00:00

  • Isolation, characterization and biological significance of hepatitis B virus mutants from serum of a patient with immunologically negative HBV infection.

    abstract：BACKGROUND/AIM:A low-titered hepatitis B virus infection without immunological markers was identified in a prospective study in the serum of a kidney transplant recipient by PCR. The aim of this study was to analyze HBV genomes and their biological significance. METHODS:The genome was amplified in two overlapping frag...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80313-x

    authors： Schories M,Peters T,Rasenack J

    更新日期：2000-11-01 00:00:00

  • Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.

    abstract：BACKGROUND/AIMS:Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized tha...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.09.019

    authors： Nguyen JH,Yamamoto S,Steers J,Sevlever D,Lin W,Shimojima N,Castanedes-Casey M,Genco P,Golde T,Richelson E,Dickson D,McKinney M,Eckman CB

    更新日期：2006-06-01 00:00:00

  • Fibrosis and alcohol-related liver disease.

    abstract：:Histological fibrosis stage is one of the most important prognostic factors in compensated and decompensated alcohol-related liver disease (ALD). Morphological assessment of fibrosis is useful for patient stratification, enabling individualised management, and for evaluation of treatment effects in clinical studies. I...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2018.12.003

    authors： Lackner C,Tiniakos D

    更新日期：2019-02-01 00:00:00

  • The "interferon sensitivity determining region" of hepatitis C virus is a stable sequence element.

    abstract：BACKGROUND/AIMS:A sequence of 40 amino acids within the nonstructural protein 5A of hepatitis C virus (HCV) has been suggested to be an interferon sensitivity determining region (ISDR). The variations in the ISDR after 12-14 years of chronic infection and the correlation between ISDR and interferon response were studie...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(98)80051-2

    authors： Rispeter K,Lu M,Zibert A,Wiese M,de Oliveira JM,Roggendorf M

    更新日期：1998-09-01 00:00:00

  • Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00217-3

    authors： Puthumana L,Chaudhry V,Thuluvath PJ

    更新日期：2001-12-01 00:00:00

  • A randomized controlled trial of recombinant interferon alpha-2b in the treatment of Chinese patients with acute post-transfusion hepatitis C.

    abstract：:To evaluate the efficacy of recombinant interferon alpha-2b in the treatment of patients with acute post-transfusion hepatitis C, a randomized controlled trial was conducted in 33 acute post-transfusion hepatitis C patients; 16 patients received 3 million units of subcutaneously injected recombinant interferon alpha-2...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(94)80246-7

    authors： Hwang SJ,Lee SD,Chan CY,Lu RH,Lo KJ

    更新日期：1994-11-01 00:00:00

  • Quantification of HBV core antibodies may help predict HBV reactivation in patients with lymphoma and resolved HBV infection.

    abstract：BACKGROUND & AIMS:Absence or low anti-HBV surface antibody (anti-HBs) is associated with an increased risk of HBV reactivation in patients with lymphoma and resolved HBV infection receiving rituximab-containing chemotherapy. Quantification of anti-HBV core antibody (anti-HBc) is a new marker associated with the natural...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.02.033

    authors： Yang HC,Tsou HH,Pei SN,Chang CS,Chen JH,Yao M,Lin SJ,Lin J,Yuan Q,Xia N,Liu TW,Chen PJ,Cheng AL,Hsu C,Taiwan Cooperative Oncology Group.

    更新日期：2018-08-01 00:00:00

  • Autonomic dysfunction in patients with non-alcoholic chronic liver disease.

    abstract：AIMS:To assess the presence of autonomic neuropathy in patients with non-alcoholic chronic liver disease and its relationships with the severity of liver damage. METHODS:Thirty non-alcoholic patients with chronic liver disease and 26 healthy control subjects were studied. The silicone imprint technique was used to qua...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80458-8

    authors： Oliver MI,Miralles R,Rubíes-Prat J,Navarro X,Espadaler JM,Solá R,Andreu M

    更新日期：1997-06-01 00:00:00

  • Effect of amphotericin B on hepatic cytochrome P-450 and glucose-6-phosphatase in the rat.

    abstract：:The effect of amphotericin B on hepatic microsomal cytochrome P-450 (P-450) concentration was measured in vitro, in vivo and ex vivo in the rat. In vitro, both amphotericin B (0-500 micrograms/ml) and its vehicle, sodium deoxycholate (0-410 micrograms/ml), caused similar dose-dependent decreases of P-450 concentration...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90174-n

    authors： Heidemann H,Holzlöhner U,Heydemann J,Freitag T,Inselmann G

    更新日期：1992-03-01 00:00:00

  • Release of lysosomal enzymes is not correlated with superoxide and prostaglandin production by stimulated rat Kupffer cells in primary culture.

    abstract：:A substantial production of prostaglandin E2 (PGE2) was induced in primary cultures of rat Kupffer cells by zymosan, calcium ionophore A23187, phorbol ester and arachidonic acid, whereas contact with latex particles, glucan or immunocomplexes led to a minor PGE2 release only. Superoxide generation, on the other hand, ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80028-x

    authors： Dieter P,Schulze-Specking A,Decker K

    更新日期：1988-04-01 00:00:00

  • A predictive model of treatment outcome in patients with chronic HCV infection using IL28B and PD-1 genotyping.

    abstract：BACKGROUND & AIMS:The advent of new chronic hepatitis C virus (HCV) therapies requires characterization of patients in order to predict adequate treatment. A good candidate marker is Programmed Cell Death-1 (PD-1) which is involved in progression of HCV infection. The aim of this study was to analyse the effect of seve...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.01.011

    authors： Vidal-Castiñeira JR,López-Vázquez A,Alonso-Arias R,Moro-García MA,Martinez-Camblor P,Melón S,Prieto J,López-Rodriguez R,Sanz-Cameno P,Rodrigo L,Pérez-López R,Pérez-Álvarez R,López-Larrea C

    更新日期：2012-06-01 00:00:00

  • Liver stiffness is directly influenced by central venous pressure.

    abstract：BACKGROUND & AIMS:Liver stiffness (LS) as measured by transient elastography [Fibroscan] offers a novel non-invasive approach to assess liver cirrhosis. Since Fibroscan seems to be unreliable in patients with congestive heart failure, it remains to be determined whether hemodynamic changes affect LS irrespective of fib...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.11.018

    authors： Millonig G,Friedrich S,Adolf S,Fonouni H,Golriz M,Mehrabi A,Stiefel P,Pöschl G,Büchler MW,Seitz HK,Mueller S

    更新日期：2010-02-01 00:00:00

  • Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.

    abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.01.027

    authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

    更新日期：2009-06-01 00:00:00

  • Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion.

    abstract：BACKGROUND & AIMS:Hepatitis B e antigen (HBeAg) seroconversion is an important clinical and virological "landmark" during chronic hepatitis B virus (HBV) infection. Mutant viruses carrying the precore G1896A and/or the basal core promoter (BCP) A1762T/G1764A mutations are associated with HBeAg seroconversion. However, ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.11.012

    authors： Nie H,Evans AA,London WT,Block TM,Ren XD

    更新日期：2012-04-01 00:00:00

  • Liver biopsy in liver transplantation: no additional risk of infections in patients with choledochojejunostomy.

    abstract：BACKGROUND/AIMS:This study aimed to determine whether there is an increased infectious risk following liver biopsy in liver transplant patients with choledochojejunostomy. METHODS:We evaluated the incidence of liver-biopsy-related sepsis in a consecutive series of 27 patients who underwent choledochojejunostomy, eithe...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80012-2

    authors： Ben-Ari Z,Neville L,Rolles K,Davidson B,Burroughs AK

    更新日期：1996-03-01 00:00:00

  • Deriving the optimal limit of detection for an HCV point-of-care test for viraemic infection: Analysis of a global dataset.

    abstract：BACKGROUND & AIMS:Affordable point-of-care tests for hepatitis C (HCV) viraemia are needed to improve access to treatment in low- and middle-income countries. Our aims were to determine the target limit of detection (LOD) necessary to diagnose the majority of people with HCV eligible for treatment, and identify charact...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.02.011

    authors： Freiman JM,Wang J,Easterbrook PJ,Horsburgh CR,Marinucci F,White LF,Kamkamidze G,Krajden M,Loarec A,Njouom R,Nguyen KV,Shiha G,Soliman R,Solomon SS,Tsertsvadze T,Denkinger CM,Linas B

    更新日期：2019-07-01 00:00:00