当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis.

Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis.

Abstract：

BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc interval were determined in 130 patients (Child A 42, B 53, C 35) with alcoholic and non-alcoholic liver disease. RESULTS:Prolonged QTc (>440ms) was seen in 58 (Child A 30%, B 46%, C 60%, P=0.04) patients. Autonomic tests were normal in 21%, borderline abnormal in 36% and definitely abnormal in 43%. QTc correlated with albumin (P<0.001), prothrombin time (P=0.003) and Child-Pugh score (P<0.001), but not with Valsalva ratio, heart rate variation with 6 breath/min breathing, tilt table or isometric exercise. By logistic regression analysis, QTc correlated only with Child-Pugh score (P<0.001). Mean QTc of 34 who died during the follow up was higher than survivors. Cox regression analysis showed that only Child-Pugh score and AN were independent predictors of mortality. CONCLUSIONS:Prolonged QTc seen in liver disease is independent of their cardiac autonomic function, but is related to the severity of the liver disease.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Puthumana L,Chaudhry V,Thuluvath PJ

doi

10.1016/s0168-8278(01)00217-3

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

733-8

issue

6

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(01)00217-3

journal_volume

35

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome.

    abstract：BACKGROUND/AIMS:The independent role of soft drink consumption in non-alcoholic fatty liver disease (NAFLD) patients remains unclear. We aimed to assess the association between consumption of soft drinks and fatty liver in patients with or without metabolic syndrome. METHODS:We recruited 31 patients (age: 43+/-12 year...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.05.033

    authors： Abid A,Taha O,Nseir W,Farah R,Grosovski M,Assy N

    更新日期：2009-11-01 00:00:00

  • Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1.

    abstract：BACKGROUND/AIMS:Although matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs) play an essential role in liver injury associated with tissue remodeling, the cellular origin of MMPs/TMPs within the liver remains to be clarified. METHODS:Different liver cell populations were analysed with respect to the...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80007-5

    authors： Knittel T,Mehde M,Kobold D,Saile B,Dinter C,Ramadori G

    更新日期：1999-01-01 00:00:00

  • Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications.

    abstract：BACKGROUND & AIMS:Despite the clinical and genetic significance of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC), its characteristics on imaging have not been described. This study aimed to characterise MTM-HCC on gadoxetic acid-enhanced MRI and to evaluate the diagnostic accuracy and prognostic value of t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.08.013

    authors： Rhee H,Cho ES,Nahm JH,Jang M,Chung YE,Baek SE,Lee S,Kim MJ,Park MS,Han DH,Choi JY,Park YN

    更新日期：2021-01-01 00:00:00

  • The classification and biological functions of the interferons. A review.

    abstract：:There are three main types of interferon, now designated alpha, beta and gamma. Human interferons-alpha exist as many subtypes, probably more than 26. These are chemically quite closely related, but each has a unique chemical composition and biological properties. Preparations of interferon-alpha derived from stimulat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(86)80115-5

    authors： Finter NB

    更新日期：1986-01-01 00:00:00

  • The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.

    abstract：BACKGROUND/AIMS:The organic anion transporting polypeptides (OATPs) mediate the uptake of numerous amphipathic compounds into hepatocytes. Our aim was to study the expression and regulation of OATP8 (OATP1B3, SLC21A8/SLCO1B3) and OATP-C (OATP1B1, SLC21A6/SLCO1B1) in hepatocellular carcinomas (HCC). METHODS:RNA and pro...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2003.10.008

    authors： Vavricka SR,Jung D,Fried M,Grützner U,Meier PJ,Kullak-Ublick GA

    更新日期：2004-02-01 00:00:00

  • HBe antibody unrelated to 'e minus' hepatitis B virus variant infection in patients with chronic type D hepatitis.

    abstract：:The presence of HBV-DNA sequences was evaluated in DNA extracted from serum samples, peripheral blood lymphocytes and liver biopsy specimens of five HBsAg/anti-HBe-positive carriers with chronic HDV infection. DNAs were tested by polymerase chain reaction (PCR) amplification technique using two pairs of oligonucleotid...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90032-7

    authors： Raimondo G,Rodinò G,Brancatelli S,Sardo MA,Campo S,Smedile V,Villari D,Pernice M,Longo G,Squadrito G

    更新日期：1991-01-01 00:00:00

  • Effects of propranolol and sucralfate on ethanol-induced gastric mucosal damage in chronic portal hypertensive rats.

    abstract：:In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80568-8

    authors： Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

    更新日期：1987-10-01 00:00:00

  • Oncostatin M stimulates tissue inhibitor of metalloproteinase-1 via a MEK-sensitive mechanism in human myofibroblasts.

    abstract：BACKGROUND/AIMS:We previously showed that in cultured human myofibroblasts (hMFBs), Oncostatin M (OSM)-stimulated collagen accumulation is associated with increased tissue inhibitor of metalloproteinase (TIMP)1 message. However, the mechanism is unknown. METHODS:hMFBs were isolated by outgrowth from cirrhotic liver ex...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00265-3

    authors： Sohara N,Trojanowska M,Reuben A

    更新日期：2002-02-01 00:00:00

  • Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen.

    abstract：BACKGROUND/AIMS:The pathophysiology of binge drinking of ethanol and its potentiation of acetaminophen (APAP) toxicity has received very little attention. To evaluate if ethanol binging sensitizes hepatic sinusoidal endothelial cells (SEC) and liver to APAP toxicity. METHODS:The histopathological responses to APAP wer...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.11.033

    authors： McCuskey RS,Bethea NW,Wong J,McCuskey MK,Abril ER,Wang X,Ito Y,DeLeve LD

    更新日期：2005-03-01 00:00:00

  • Transactivating function and expression of the x gene of hepatitis B virus.

    abstract：BACKGROUND/AIMS:The x gene of hepatitis B virus encodes a transactivating factor of 154 amino acids, termed HBx, which stimulates transcription of multiple viral and cellular genes. The transactivating function is probably associated with a tumorigenic potential of HBx, since x gene sequences, encoding functional HBx, ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80311-4

    authors： Renner M,Haniel A,Bürgelt E,Hofschneider PH,Koch W

    更新日期：1995-07-01 00:00:00

  • Visceral adiposity index is not a predictor of liver histology in patients with non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:Visceral adiposity is associated with hepatic steatosis, inflammation, and fibrosis in non-alcoholic fatty liver disease (NAFLD). The visceral adiposity index (VAI), a novel marker of visceral fat distribution and dysfunction, has been correlated with histology in hepatitis C. We assessed the ability ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.03.013

    authors： Vongsuvanh R,George J,McLeod D,van der Poorten D

    更新日期：2012-08-01 00:00:00

  • Urinary 7alpha-hydroxy-3-oxochol-4-en-24-oic and 3-oxochola-4,6-dien-24-oic acids in infants with cholestasis.

    abstract：BACKGROUND/AIMS:Urinary 3-oxo-delta4 bile acids have been detected in infants who ultimately died of liver disease. We used qualitative and quantitative methods to compare urinary 3-oxo-delta4 bile acids in liver disease, determining their composition and evaluating the prognostic implication in patients of various age...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(88)80014-x

    authors： Kimura A,Suzuki M,Murai T,Kurosawa T,Tohma M,Sata M,Inoue T,Hoshiyama A,Nakashima E,Yamashita Y,Fujisawa T,Kato H

    更新日期：1998-02-01 00:00:00

  • New molecular insights into the mechanisms of cholestasis.

    abstract：:Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibil...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2009.05.012

    authors： Wagner M,Zollner G,Trauner M

    更新日期：2009-09-01 00:00:00

  • Microsteatosis may not interact with macrosteatosis in living donor liver transplantation.

    abstract：BACKGROUND & AIMS:The insignificance of pure microsteatosis (MiS) was reported in living donor liver transplantation (LDLT). However, since steatosis is mostly found in a mixed form of microsteatosis (MiS) and macrosteatosis (MaS), we aimed to determine the importance of MiS mixed with MaS in LDLT. METHODS:Donor match...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.10.027

    authors： Han S,Ha SY,Park CK,Joh JW,Kwon CH,Kwon GY,Kim G,Gwak MS,Jeong WK,Ko JS

    更新日期：2015-03-01 00:00:00

  • High doses of aminoglycosides did not produce liver toxicity in patients with cystic fibrosis.

    abstract：:Liver disease is common in patients with cystic fibrosis, but the pathogenesis is poorly understood. The chronic colonization of bacteria in the lower airways leads to repeated treatments with antibiotics, especially aminoglycosides in high dosages. To investigate the possible role of aminoglycoside treatment in the n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80058-3

    authors： Lindblad A,Hultcrantz R,Strandvik B

    更新日期：1994-02-01 00:00:00

  • The efficacy and safety of pegylated interferon plus ribavirin combination therapy in chronic hepatitis c patients with hepatocellular carcinoma post curative therapies - a multicenter prospective trial.

    abstract：BACKGROUND & AIMS:Evidence on the efficacy of antiviral treatment in chronic hepatitis C (CHC) patients with hepatocellular carcinoma (HCC) after curative treatment is scarce. We aimed to evaluate the efficacy and safety of pegylated interferon-alpha plus ribavirin (pegIFN/RBV) combination therapy in these patients, co...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2010.07.011

    authors： Huang JF,Yu ML,Huang CF,Chiu CF,Dai CY,Huang CI,Yeh ML,Yang JF,Hsieh MY,Hou NJ,Lin ZY,Chen SC,Wang LY,Chuang WL

    更新日期：2011-02-01 00:00:00

  • Non-organ specific autoantibodies associated with chronic C virus hepatitis.

    abstract：:Recently antibodies to hepatitis C virus were detected in sera of chronic active hepatitis patients, with anti-smooth muscle autoantibodies or with anti-liver/kidney microsomal type 1 autoantibodies. As the latter were used to differentiate autoimmune chronic active hepatitis from chronic non-A, non-B virus hepatitis,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80281-8

    authors： Abuaf N,Lunel F,Giral P,Borotto E,Laperche S,Poupon R,Opolon P,Huraux JM,Homberg JC

    更新日期：1993-07-01 00:00:00

  • Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.

    abstract：BACKGROUND & AIMS:Acetaminophen (APAP)-induced liver injury is the most frequent cause of acute liver failure in the US and many other countries. Metabolism of APAP results in formation of APAP protein adducts (APAP-AD) in hepatocytes and triggers mitochondrial dysfunction and necrosis. However, the mechanisms for how ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2016.04.025

    authors： Ni HM,McGill MR,Chao X,Du K,Williams JA,Xie Y,Jaeschke H,Ding WX

    更新日期：2016-08-01 00:00:00

  • Interleukins in chronic active hepatitis B. Relationship with viral markers.

    abstract：:Interleukin-2, a product of helper T cells, is essentially involved in the regulation of cell-mediated immunity. Two monocyte-derived factors, interleukin-1 and prostaglandin E2, influence interleukin-2 synthesis with opposite actions. To analyse immunoregulatory function in HBsAg-positive chronic active hepatitis, T ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80059-4

    authors： Civeira M,Prieto J,Morte S,Riñon M,Serrano M

    更新日期：1987-08-01 00:00:00

  • Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices.

    abstract：BACKGROUND/AIMS:Periodic endoscopic screening for oesophageal varices is recommended in patients with cirrhosis, but might be limited to a subgroup of patients if a simple non-invasive test was available to select those at risk of bleeding. METHODS:We studied in 165 patients with cirrhosis the relation between the pre...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.04.006

    authors： Kazemi F,Kettaneh A,N'kontchou G,Pinto E,Ganne-Carrie N,Trinchet JC,Beaugrand M

    更新日期：2006-08-01 00:00:00

  • Influence of viral hepatitis on HIV infection.

    abstract：:The natural history of HBV is known to be complicated by HIV-co-infection. In contrast, the effect of HBV on the outcome of patients infected with HIV-1 is controversial. Some cohort studies from the pre-HAART era described a more rapid progression to AIDS in patients carrying antibodies to the core-antigen or having ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2005.11.007

    authors： Rockstroh JK

    更新日期：2006-01-01 00:00:00

  • Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

    abstract：BACKGROUND & AIMS:Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H(2)O(2) by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H(2)O(2) reduction, we explored the interplay between superoxide, H(2)O(2), and mGSH in n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.05.024

    authors： von Montfort C,Matias N,Fernandez A,Fucho R,Conde de la Rosa L,Martinez-Chantar ML,Mato JM,Machida K,Tsukamoto H,Murphy MP,Mansouri A,Kaplowitz N,Garcia-Ruiz C,Fernandez-Checa JC

    更新日期：2012-10-01 00:00:00

  • Significance of increased plasma adrenomedullin concentration in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:Adrenomedullin recently discovered in human pheochromocytoma is a potent vasodilatory peptide mainly derived from vascular endothelial and smooth muscle cells. Hyperdynamic circulation, ultimately leading to ascites formation, has been attributed to peripheral vasodilatation in liver cirrhosis. However,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(98)80235-3

    authors： Kojima H,Tsujimoto T,Uemura M,Takaya A,Okamoto S,Ueda S,Nishio K,Miyamoto S,Kubo A,Minamino N,Kangawa K,Matsuo H,Fukui H

    更新日期：1998-05-01 00:00:00

  • Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

    abstract：BACKGROUND & AIMS:Hallmarks of non-alcoholic fatty liver disease (NAFLD) are increased triglyceride accumulation within hepatocytes. The prevalence of NAFLD increases steadily with increasing thyrotropin (TSH) levels. However, the underlying mechanisms are largely unknown. Here, we focused on exploring the effect and m...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.06.037

    authors： Yan F,Wang Q,Lu M,Chen W,Song Y,Jing F,Guan Y,Wang L,Lin Y,Bo T,Zhang J,Wang T,Xin W,Yu C,Guan Q,Zhou X,Gao L,Xu C,Zhao J

    更新日期：2014-12-01 00:00:00

  • Decrease in serum ALT and increase in serum HCV RNA during pregnancy in women with chronic hepatitis C.

    abstract：BACKGROUND/AIMS:The natural history of chronic hepatitis C infection during pregnancy has not been clearly established, and thus our aim was to assess serum alanine aminotransferase levels and serum HCV RNA levels during pregnancy. METHODS:Twenty-six pregnant women with chronic hepatitis C were studied. Serum alanine ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80075-6

    authors： Gervais A,Bacq Y,Bernuau J,Martinot M,Auperin A,Boyer N,Kilani A,Erlinger S,Valla D,Marcellin P

    更新日期：2000-02-01 00:00:00

  • Altered pathogenicity in the liver induced by a mouse hepatitis virus type 3 thermosensitive mutant.

    abstract：:Intraperitoneal inoculation into sensitive BALB/c mice of D85, a thermosensitive (ts) mutant, provokes acute hepatitis followed by recovery of the mice. The ts mutant was able to replicate in the liver. However, the maximal viral titre was obtained 2 days later than was the case with the wild-type (wt) MHV 3 infection...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90865-9

    authors： Martin JP,Bingen A,Koehren F,Gut JP,Kirn A

    更新日期：1991-07-01 00:00:00

  • Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.

    abstract：BACKGROUND/AIMS:Interaction between CYP2E1, ethanol metabolites, and enhanced lipid peroxidation is linked to the pathogenesis of alcoholic liver disease. This study was conducted to compare the expression of various cytochrome enzymes and the appearance of aldehyde adducts in humans. METHODS:Acetaldehyde- and lipid p...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80120-8

    authors： Niemelä O,Parkkila S,Juvonen RO,Viitala K,Gelboin HV,Pasanen M

    更新日期：2000-12-01 00:00:00

  • New target region of allelic loss in hepatocellular carcinomas within a 1-cM interval on chromosome 6q23.

    abstract：BACKGROUND/AIMS:Frequent allelic losses on the long arm of chromosome 16 in several types of human cancers have suggested that 16q harbors one or more genes that are important for suppressing tumorigenesis in the tissues in question. METHODS:To identify the locations of putative tumor suppressor genes involved in hepa...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80163-4

    authors： Koyama M,Nagai H,Bando K,Matsumoto S,Tajiri T,Onda M,Ito M,Moriyama Y,Emi M

    更新日期：2000-07-01 00:00:00

  • Management of anemia induced by triple therapy in patients with chronic hepatitis C: challenges, opportunities and recommendations.

    abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2013.07.014

    authors： Romero-Gómez M,Berenguer M,Molina E,Calleja JL

    更新日期：2013-12-01 00:00:00

  • HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice.

    abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) is a major etiologic agent of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The aim of this study was to elucidate pathological effects of HCV-core protein on liver cells. METHODS:We have generated transgenic mice carrying HCV-core cDNA (Px-core) and pathologically...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80280-9

    authors： Honda A,Hatano M,Kohara M,Arai Y,Hartatik T,Moriyama T,Imawari M,Koike K,Yokosuka O,Shimotohno K,Tokuhisa T

    更新日期：2000-09-01 00:00:00