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New molecular insights into the mechanisms of cholestasis.

Abstract：

:Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibility and disease progression in acquired cholestatic disorders. Cholestasis is associated with complex transcriptional and post-transcriptional alterations of hepatobiliary transporters and enzymes participating in bile formation. Ligand-activated nuclear receptors for bile acids and other biliary compounds play a key role in the regulation of genes required for bile formation. Pharmacological interventions in cholestasis may aim at modulating such novel regulatory pathways. This review will summarize the principles of molecular alterations in cholestasis and will give an overview of potential clinical implications.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Wagner M,Zollner G,Trauner M

doi

10.1016/j.jhep.2009.05.012

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

565-80

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(09)00365-1

journal_volume

51

pub_type

杂志文章,评审

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