Effects of HIV superinfection on HBV replication in a chronic HBsAg carrier with liver disease.

Abstract:

:A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication lasting for several months as detected by an increase of the HBV-DNA concentration in the serum. Our observations suggest that the reduction of hepatocyte necrosis and the increase in HBV replication were a consequence of impaired T cell function during acute HIV infection.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Pastore G,Santantonio T,Monno L,Milella M,Luchena N,Angarano G

doi

10.1016/s0168-8278(88)80478-1

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

164-8

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(88)80478-1

journal_volume

7

pub_type

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