Evolutionary biology of human hepatitis viruses.

Abstract:

:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human hepatitis viruses and their animal homologues, including transmission routes, liver tropism, oncogenesis, chronicity, pathogenesis and envelopment. We discuss the potential for translation of newly discovered hepatitis viruses into preclinical animal models for drug testing, studies on pathogenesis and vaccine development. Finally, we re-evaluate the evolutionary origins of human hepatitis viruses and discuss the past and present zoonotic potential of their animal homologues.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Rasche A,Sander AL,Corman VM,Drexler JF

doi

10.1016/j.jhep.2018.11.010

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

501-520

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(18)32542-X

journal_volume

70

pub_type

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