Evolutionary biology of human hepatitis viruses.


:Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Herein, we describe both surprising conservation and striking differences of the unique biological properties and infection patterns of human hepatitis viruses and their animal homologues, including transmission routes, liver tropism, oncogenesis, chronicity, pathogenesis and envelopment. We discuss the potential for translation of newly discovered hepatitis viruses into preclinical animal models for drug testing, studies on pathogenesis and vaccine development. Finally, we re-evaluate the evolutionary origins of human hepatitis viruses and discuss the past and present zoonotic potential of their animal homologues.


J Hepatol


Journal of hepatology


Rasche A,Sander AL,Corman VM,Drexler JF




Has Abstract


2019-03-01 00:00:00














  • Impairment of metabolic hepatic nerve action by chronic but not acute ethanol intoxication studied in isolated perfused rat liver.

    abstract:BACKGROUND/AIMS:Liver carbohydrate metabolism and blood flow are regulated by hepatic nerves and hormones such as glucagon, insulin or catecholamines. Acute and chronic application of alcohol are known to depress the function of central and peripheral nerves. The extent of inhibition of the autonomic nervous system is ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kucera T,Stümpel F,Jungermann K

    更新日期:1997-01-01 00:00:00

  • Therapeutic strategies in inflammasome mediated diseases of the liver.

    abstract::Tissue stress and cell death result in inflammation even in the absence of pathogens. Such sterile inflammation is dependent on a cytosolic complex of proteins inside immune cells termed the inflammasome. This complex converts two groups of extracellular signals into an inflammatory response via activation of caspase-...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hoque R,Vodovotz Y,Mehal W

    更新日期:2013-05-01 00:00:00

  • Dendritic cell maturation in HCV infection: altered regulation of MHC class I antigen processing-presenting machinery.

    abstract:BACKGROUND & AIMS:Modulation of dendritic cell (DC) function has been theorized as one of the mechanisms used by hepatitis C virus (HCV) to evade the host immune response and cause persistent infection. METHODS:We used a range of cell and molecular biology techniques to study DC subsets from uninfected and HCV-infecte...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Leone P,Di Tacchio M,Berardi S,Santantonio T,Fasano M,Ferrone S,Vacca A,Dammacco F,Racanelli V

    更新日期:2014-08-01 00:00:00

  • A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results.

    abstract::The results of a 3-year, placebo-controlled trial of prednisolone treatment in primary biliary cirrhosis (PBC) are presented. The active (n = 19) and placebo (n = 17) arms were initially well matched for age, menopausal status and disease severity. At 3 years hepatic symptoms were relatively improved in the prednisolo...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mitchison HC,Palmer JM,Bassendine MF,Watson AJ,Record CO,James OF

    更新日期:1992-07-01 00:00:00

  • Hepatic regeneration in insulin-like growth factor binding protein-1 transgenic mice.

    abstract:BACKGROUND/AIMS:Partial hepatectomy results in activation of genes in the residual liver tissue which serve to restore glucose homeostasis and regenerate liver mass. Expression of insulin-like growth factor binding protein-1 (IGFBP-1) is up-regulated following partial hepatectomy and IGFBP-1 can modulate both the metab...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Liu YY,Rajkumar K,Murphy LJ

    更新日期:1999-04-01 00:00:00

  • Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:The MAGE, GAGE and BAGE genes encode tumor antigens recognized by autologous cytotoxic T lymphocytes. The aim of this study was to evaluate the possibility of using these genes as molecular markers and as the targets of specific immunotherapy for human hepatocellular carcinoma (HCC). METHODS:The expres...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kobayashi Y,Higashi T,Nouso K,Nakatsukasa H,Ishizaki M,Kaneyoshi T,Toshikuni N,Kariyama K,Nakayama E,Tsuji T

    更新日期:2000-04-01 00:00:00

  • Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma.

    abstract::Surveillance of patients at risk of developing hepatocellular carcinoma (HCC) is based on ultrasound (US) examinations performed at either 6 or 12 month intervals. Early detection of HCC in patients with cirrhosis is a challenging issue, since the different entities that are involved in the multi-step process of hepat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Lencioni R,Piscaglia F,Bolondi L

    更新日期:2008-05-01 00:00:00

  • Targeted vaccination programme successful in reducing acute hepatitis B in men having sex with men in Amsterdam, the Netherlands.

    abstract:BACKGROUND & AIMS:In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's larg...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: van Rijckevorsel G,Whelan J,Kretzschmar M,Siedenburg E,Sonder G,Geskus R,Coutinho R,van den Hoek A

    更新日期:2013-12-01 00:00:00

  • Safety and efficacy of in vitro fertilisation in patients with chronic liver disease and liver transplantation recipients.

    abstract:BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

    更新日期:2021-01-15 00:00:00

  • Defective aggregation in cirrhosis is independent of in vivo platelet activation.

    abstract:BACKGROUND/AIMS:Platelet function abnormalities contribute to the hemostatic defect in patients with cirrhosis. In this study we evaluated the occurrence of in vivo platelet activation as a possible mechanism of defective platelet aggregation in patients with cirrhosis. METHODS:Nine patients with severe (Child B-C) ci...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Laffi G,Cinotti S,Filimberti E,Ciabattoni G,Caporale R,Marra F,Melani L,Grossi A,Carloni V,Gentilini P

    更新日期:1996-04-01 00:00:00

  • Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α.

    abstract:BACKGROUND & AIMS:Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and func...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Chen KT,Pernelle K,Tsai YH,Wu YH,Hsieh JY,Liao KH,Guguen-Guillouzo C,Wang HW

    更新日期:2014-12-01 00:00:00

  • Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:Little is known about the nucleotide excision repair (NER) pathway in the resistance of human hepatocellular carcinoma (HCC) to chemotherapeutics. We investigated expression of several NER genes in human HCC and matching non-tumor tissue (NT) and in normal liver. METHODS:Expression of CSA, CSB, XPC, hH...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Fautrel A,Andrieux L,Musso O,Boudjema K,Guillouzo A,Langouët S

    更新日期:2005-08-01 00:00:00

  • Treatment of concanavalin A-induced hepatitis in mice with low molecular weight heparin.

    abstract:BACKGROUND/AIMS:Heparin has been noted to inhibit inflammation independent of its known anti-coagulant activity. In the present study, we examined the ability of heparin and low molecular weight heparin to prevent immune-mediated, concanavalin A-induced liver damage. METHODS:Mice were pretreated with either heparin or...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hershkoviz R,Bruck R,Aeed H,Shirin H,Halpern Z

    更新日期:1999-11-01 00:00:00

  • Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan.

    abstract:BACKGROUND & AIMS:To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C. METHODS:In a multi-center randomized clinical trial in Japan, on patients infected with HCV of genotype 1, 126 patients were assigned to telaprev...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kumada H,Toyota J,Okanoue T,Chayama K,Tsubouchi H,Hayashi N

    更新日期:2012-01-01 00:00:00

  • Significance of increased plasma adrenomedullin concentration in patients with cirrhosis.

    abstract:BACKGROUND/AIMS:Adrenomedullin recently discovered in human pheochromocytoma is a potent vasodilatory peptide mainly derived from vascular endothelial and smooth muscle cells. Hyperdynamic circulation, ultimately leading to ascites formation, has been attributed to peripheral vasodilatation in liver cirrhosis. However,...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kojima H,Tsujimoto T,Uemura M,Takaya A,Okamoto S,Ueda S,Nishio K,Miyamoto S,Kubo A,Minamino N,Kangawa K,Matsuo H,Fukui H

    更新日期:1998-05-01 00:00:00

  • Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.

    abstract::Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiation codon and three am...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Fernholz D,Stemler M,Brunetto M,Bonino F,Will H

    更新日期:1991-01-01 00:00:00

  • DR human leukocyte antigens and disease severity in chronic hepatitis C.

    abstract:BACKGROUND/AIMS:Immune mechanisms may modulate disease severity in chronic hepatitis C and the DR human leukocyte antigens may affect these mechanisms. Our aims were to evaluate the association between the DR antigens and disease severity at presentation and to seek correlation between these antigens, disease severity ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Czaja AJ,Carpenter H,Santrach PJ,Moore SB

    更新日期:1996-06-01 00:00:00

  • Identification of naïve HCV-1 patients with chronic hepatitis who may benefit from dual therapy with peg-interferon and ribavirin.

    abstract:BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

    更新日期:2014-01-01 00:00:00

  • Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis.

    abstract:BACKGROUND & AIM:Virus-induced fulminant hepatitis is a major cause of acute liver failure. During acute viral hepatitis the impact of type I interferon (IFN-I) on myeloid cells, including liver-resident Kupffer cells (KC), is only partially understood. Herein, we dissected the impact of locally induced IFN-I responses...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Borst K,Frenz T,Spanier J,Tegtmeyer PK,Chhatbar C,Skerra J,Ghita L,Namineni S,Lienenklaus S,Köster M,Heikenwaelder M,Sutter G,Kalinke U

    更新日期:2018-04-01 00:00:00

  • Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient.

    abstract::An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kremsdorf D,Garreau F,Duclos H,Thiers V,Schellekens H,Petit MA,Bréchot C

    更新日期:1993-06-01 00:00:00

  • Prolonged treatment (18 months) of chronic hepatitis C with recombinant alpha-interferon in comparison with a control group.

    abstract::The effectiveness of recombinant alpha-interferon was evaluated in chronic non-A, non-B hepatitis of parenteral transmission. Thirty patients were randomly allocated two groups: control group (without treatment) and treatment group (alpha-interferon 5 mega units thrice weekly for 2 months, and then 1.5 mega units unti...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gómez-Rubio M,Porres JC,Castillo I,Quiroga JA,Moreno A,Carreño V

    更新日期:1990-01-01 00:00:00

  • Prevalence of hepatitis C viral infection in a community in Taiwan. Detection by synthetic peptide-based assay and polymerase chain reaction.

    abstract::The prevalence of antibodies to hepatitis C virus (anti-HCV) in a hepatitis B virus hyperendemic region was evaluated with a second-generation enzyme immunoassay. A general population of 1500 from Northern Taiwan was tested with this immunoassay which includes synthetic peptides from the capsid and non-structural prot...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Sheu JC,Wang JT,Wang TH,Wang CY,Yang PM,Huang GT,Shih LN,Lee HS,Chen DS

    更新日期:1993-02-01 00:00:00

  • Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

    abstract::Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD has traditionally been considered a consequence of metabolic syndrome (MetS). However, the link between NAFLD and MetS components, especially typ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Lonardo A,Nascimbeni F,Mantovani A,Targher G

    更新日期:2018-02-01 00:00:00

  • An ultrasound scoring system for the diagnosis of liver disease in cystic fibrosis.

    abstract::Advances in the management of the pulmonary complications of cystic fibrosis may result in an increasing prevalence of patients with chronic liver disease which may, therefore, become more important in the long-term management of cystic fibrosis patients. However, no simple and reliable test is available for the diagn...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Williams SG,Evanson JE,Barrett N,Hodson ME,Boultbee JE,Westaby D

    更新日期:1995-05-01 00:00:00

  • The lung in patients with cirrhosis.

    abstract::To summarize, nowadays it seems clear that in patients with cirrhosis: (a) the pulmonary circulation is usually markedly dilated. (b) This vasodilation is due to a loss of vascular tone and it is characterized by a poor (or even absent) vascular reactivity in front of the hypoxic stimulus. (c) This abnormal behaviour ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Agustí AG,Roca J,Bosch J,Rodriguez-Roisin R

    更新日期:1990-03-01 00:00:00

  • Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1.

    abstract:BACKGROUND/AIMS:The underlying mechanisms of steatosis, the first stage of non-alcoholic fatty liver disease (NAFLD) that is characterized by the accumulation of lipids in hepatocytes, remain unclear. Our study aimed to investigate the hypothesis that cigarette smoke is known to change circulating lipid profiles and th...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Yuan H,Shyy JY,Martins-Green M

    更新日期:2009-09-01 00:00:00

  • CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis.

    abstract:BACKGROUND AND AIMS:Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in non-alcoholic steatohepatitis (NASH). METHODS:Human liver tissue sam...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zhao L,Zhang C,Luo X,Wang P,Zhou W,Zhong S,Xie Y,Jiang Y,Yang P,Tang R,Pan Q,Hall AR,Luong TV,Fan J,Varghese Z,Moorhead JF,Pinzani M,Chen Y,Ruan XZ

    更新日期:2018-09-01 00:00:00

  • Ion transport in hepatocytes: mechanisms and correlations to cell volume, hormone actions and metabolism.

    abstract::Intracellular ion homeostasis in liver cell is accomplished through the concerted action of ion pumps, carriers and channels. Description of these elements includes the Na+/K+-ATPase, Na+/H+- and Cl-/ HCO3(-)-exchange and Na+-HCO-3(-)- and Na(+)-K(+)-2 Cl(-)-cotransport as well as K+-, Cl(-)-, Na+ and nonselective cat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Graf J,Häussinger D

    更新日期:1996-01-01 00:00:00

  • Global liver disease burdens and research trends: Analysis from a Chinese perspective.

    abstract::Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

    更新日期:2019-07-01 00:00:00

  • In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence.

    abstract:BACKGROUND & AIMS:We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin in established tumours had a therapeutic effect. METHODS:We used lenti...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ménard L,Taras D,Grigoletto A,Haurie V,Nicou A,Dugot-Senant N,Costet P,Rousseau B,Rosenbaum J

    更新日期:2010-05-01 00:00:00