Evolutionary biology of human hepatitis viruses.

abstract：:Since interferons are reported to inhibit collagen synthesis in vivo and in vitro, they are possible anti-fibrogenic drugs. However, little is known about the effect of interferons on connective tissue metabolism in liver disease. To investigate the effect, serum concentrations of the aminoterminal domain of procollag...

journal_title：Journal of hepatology

authors： Hayasaka A,Kohen H,Yoshikawa N,Iida S,Ohto M

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND & AIMS:In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLK...

journal_title：Journal of hepatology

authors： Majdi A,Aoudjehane L,Ratziu V,Islam T,Afonso MB,Conti F,Mestiri T,Lagouge M,Foufelle F,Ballenghien F,Ledent T,Moldes M,Cadoret A,Fouassier L,Delaunay JL,Aït-Slimane T,Courtois G,Fève B,Scatton O,Prip-Buus C,Rodrig

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND/AIMS:Combinations of beta-blockers and vasodilators have been assessed for their ability to lower portal pressure and so prevent variceal haemorrhage. However, reservations have been raised particularly with respect to renal function and perfusion after the use of these medicines in patients with chronic liv...

journal_title：Journal of hepatology

authors： Forrest EH,Bouchier IA,Hayes PC

更新日期：1996-12-01 00:00:00

abstract：:Interferon-alpha therapy has a beneficial effect in 30-40% of selected patients with chronic hepatitis B who respond by clearing hepatitis B e antigen (HBeAg) and hepatitis B viral (HBV) DNA from serum. This is usually associated with normalization of serum aminotransferase activities. On long-term follow-up of treate...

journal_title：Journal of hepatology

authors： Di Bisceglie AM

更新日期：1995-01-01 00:00:00

abstract：:We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but i...

journal_title：Journal of hepatology

authors： van 't Wout JW,Herrmann WA,de Vries RA,Stricker BH

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Primary sclerosing cholangitis (PSC) is an idiopathic, chronic cholestatic liver disorder characterized by biliary inflammation and fibrosis. Increased numbers of intrahepatic interferon-γ- (IFNγ) producing lymphocytes have been documented in patients with PSC, yet their functional role remains to b...

journal_title：Journal of hepatology

authors： Ravichandran G,Neumann K,Berkhout LK,Weidemann S,Langeneckert AE,Schwinge D,Poch T,Huber S,Schiller B,Hess LU,Ziegler AE,Oldhafer KJ,Barikbin R,Schramm C,Altfeld M,Tiegs G

更新日期：2019-10-01 00:00:00

abstract：:The reversibility and time course of the adaptive changes in hepatic bile salt transport related to modifications of the bile salt enterohepatic circulation and bile salt pool size have not been previously studied. For this reason a model of reversible interruption of entero-hepatic circulation was characterized in un...

journal_title：Journal of hepatology

authors： Accatino L,Hono J,Koenig C,Pizarro M,Rodriguez L

更新日期：1993-08-01 00:00:00

abstract：:The present study was conducted to evaluate if the increased rate of apoptosis previously reported in the liver of ethanol-treated rats was accompanied by increased cell renewal. A quantitative analysis of apoptosis was performed in rats fed an ethanol-containing liquid diet for 5 weeks. S-phase cells were demonstrate...

journal_title：Journal of hepatology

authors： Baroni GS,Marucci L,Benedetti A,Mancini R,Jezequel AM,Orlandi F

更新日期：1994-04-01 00:00:00

abstract：:The natural history of HBV is known to be complicated by HIV-co-infection. In contrast, the effect of HBV on the outcome of patients infected with HIV-1 is controversial. Some cohort studies from the pre-HAART era described a more rapid progression to AIDS in patients carrying antibodies to the core-antigen or having ...

journal_title：Journal of hepatology

authors： Rockstroh JK

更新日期：2006-01-01 00:00:00

abstract：:The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers with chronic hepatitis...

journal_title：Journal of hepatology

authors： Pignatelli M,Waters J,Lever A,Iwarson S,Gerety R,Thomas HC

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND/AIMS:Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic chol...

journal_title：Journal of hepatology

authors： Brites D,Rodrigues CM,Oliveira N,Cardoso M,Graça LM

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND & AIMS:Primary biliary cirrhosis (PBC) is believed to result from the interaction of genetic and environmental factors. The controlled studies aiming to assess risk factors for PBC are still limited. Our aim was to identify risk factors and co-morbidities associated with PBC in a large monocentric cohort. M...

journal_title：Journal of hepatology

authors： Corpechot C,Chrétien Y,Chazouillères O,Poupon R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIMS:Adipocytokines play a key role in the pathophysiology of non-alcoholic fatty liver diseases (NAFLD). Whereas adiponectin has mainly anti-inflammatory functions, leptin, resistin and pre-B cell enhancing factor (PBEF)/Nampt/visfatin are considered as mainly pro-inflammatory mediators regulating metabolic...

journal_title：Journal of hepatology

authors： Moschen AR,Molnar C,Wolf AM,Weiss H,Graziadei I,Kaser S,Ebenbichler CF,Stadlmann S,Moser PL,Tilg H

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:Several lipid synthesis pathways play important roles in the development and progression of hepatocellular carcinoma (HCC), although the precise molecular mechanisms remain to be elucidated. Here, we show the relationship between HCC progression and alteration of phospholipid composition regulated by ...

journal_title：Journal of hepatology

authors： Morita Y,Sakaguchi T,Ikegami K,Goto-Inoue N,Hayasaka T,Hang VT,Tanaka H,Harada T,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Murakami M,Setou M,Konno H

更新日期：2013-08-01 00:00:00

abstract：:TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies invivo, we show here that TGR5 sign...

journal_title：Journal of hepatology

authors： Jansen PL

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND/AIMS:Bacillus Calmette Guerin (BCG) infection causes hepatic injury following granuloma formation and secretion of cytokines which render mice highly sensitive to endotoxin-mediated hepatotoxicity. This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and en...

journal_title：Journal of hepatology

authors： Guler R,Olleros ML,Vesin D,Parapanov R,Vesin C,Kantengwa S,Rubbia-Brandt L,Mensi N,Angelillo-Scherrer A,Martinez-Soria E,Tacchini-Cottier F,Garcia I

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND & AIMS:IL28B polymorphisms, jaundice, decline in HCV-RNA, IP-10, and gender have been proposed to be indicative of spontaneous clearance of acute hepatitis C virus infection. The aim of this study was to define a score enabling the discrimination of patients with spontaneous clearance of HCV from those with ...

journal_title：Journal of hepatology

authors： Beinhardt S,Payer BA,Datz C,Strasser M,Maieron A,Dorn L,Grilnberger-Franz E,Dulic-Lakovic E,Stauber R,Laferl H,Aberle JH,Holzmann H,Krall C,Vogel W,Ferenci P,Hofer H

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND & AIMS:This study aimed to identify preoperative magnetic resonance (MR) imaging biomarkers for predicting microvascular invasion (MVI), to determine their diagnostic performance and to evaluate whether they are associated with early recurrence after surgery for single hepatocellular carcinoma (HCC). METHOD...

journal_title：Journal of hepatology

authors： Lee S,Kim SH,Lee JE,Sinn DH,Park CK

更新日期：2017-09-01 00:00:00

abstract：:Chronic hepatitis C is common in Saudi Arabia and most often presents in an advanced stage. To assess the response of patients to interferon, a randomized placebo-controlled double-blind study was undertaken. All but 1 patient had cirrhosis or fibrosis before interferon. After a 24-week observation period patients rec...

journal_title：Journal of hepatology

authors： Sieck JO,Ellis ME,Alfurayh O,Ali MA,Ali HA,Ayub A,al-Fadda M,Zafar M,Halim M,Bernvil SS

更新日期：1993-11-01 00:00:00

abstract：:A diagnostic test has been developed to detect hepatitis B virus (HBV) DNA in human sera. This test involves a dot-blot technique in which non-radioactive nucleic acid labelled with 2-acetylaminofluorene (AAF) is used as probe. Two series of human sera from 228 blood donors and 113 HBsAg chronic carriers were tested b...

journal_title：Journal of hepatology

authors： Larzul D,Thiers V,Courouce AM,Bréchot C,Guesdon JL

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND/METHODS:We recently established two hepatitis C virus (HCV) replication systems, using MT-2, a human T-cell leukemia virus type I-infected human T-cell line, and PH5CH, a non-neoplastic human hepatocyte line immortalized with simian virus 40 large T antigen. These HCV replication systems were used to assess ...

journal_title：Journal of hepatology

authors： Ikeda M,Kato N,Mizutani T,Sugiyama K,Tanaka K,Shimotohno K

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND & AIMS:High-carbohydrate diets contribute to the development of liver stress and fatty liver disease. While saturated fatty acids are known to induce liver stress, the role of monounsaturated fatty acids (MUFA), synthesized by the stearoyl-CoA desaturase (SCD) family of enzymes, in regulation of liver functi...

journal_title：Journal of hepatology

authors： Liu X,Burhans MS,Flowers MT,Ntambi JM

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/AIMS:During liver regeneration, a network of cytokines and growth factors interact with hepatocytes, helping to restore the liver mass and functions after partial tissue loss. Agonists that trigger Ca2+ signals in the liver contribute to this process, although little is known about calcium signalling during ...

journal_title：Journal of hepatology

authors： Nicou A,Serrière V,Hilly M,Prigent S,Combettes L,Guillon G,Tordjmann T

更新日期：2007-02-01 00:00:00

abstract：:Ultrastructural changes were observed in 23 consecutive patients who died from fulminant hepatic failure due to hepatitis B virus (4 cases), sporadic non-A, non-B (7), or paracetamol (acetaminophen) overdose (12) and in 3 patients with subacute hepatic necrosis of unknown cause. The findings are described in detail in...

journal_title：Journal of hepatology

authors： McCaul TF,Fagan EA,Tovey G,Portmann B,Williams R,Zuckerman AJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cholesterol crystallization in a dilute, bile salt-rich model bile is a multiphase process in which early filamentous crystals gradually transform to classical cholesterol monohydrate plates. The pertinence of similar transformations in more complex model systems or native bile is, however, unclear. The...

journal_title：Journal of hepatology

authors： Konikoff FM,Laufer H,Messer G,Gilat T

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIMS:Cystathionine beta synthase (CBS) deficiency leads to severe hyperhomocysteinemia, which confers diverse clinical manifestations, notably fatty liver. Recently, abnormal lipid metabolism has been demonstrated in CBS-deficient mice, a murine model of severe hyperhomocysteinemia. To gain further insights ...

journal_title：Journal of hepatology

authors： Hamelet J,Demuth K,Paul JL,Delabar JM,Janel N

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

journal_title：Journal of hepatology

authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

更新日期：2009-01-01 00:00:00

abstract：:Hydroxyethyl starch (HES) has gained wide clinical acceptance as a colloidal plasma substitute. We were able to study the liver biopsies of two patients with renal failure who developed ascites after repeated infusions of HES. All types of liver cells displayed massive accumulation of HES with the morphologic resembla...

journal_title：Journal of hepatology

authors： Dienes HP,Gerharz CD,Wagner R,Weber M,John HD

更新日期：1986-01-01 00:00:00

abstract：:Interleukin-6 has a variety of biological effects, mainly on the immune system. The regulation of this signal at both the site of production and the site of action is necessary to maintain the organism's homeostasis. In the microenvironment of the hepatic sinusoids, Kupffer cells as resident macrophages are the most p...

journal_title：Journal of hepatology

authors： Hoffmann R,Henninger HP,Schulze-Specking A,Decker K

更新日期：1994-10-01 00:00:00

abstract：:Interleukin-2, a product of helper T cells, is essentially involved in the regulation of cell-mediated immunity. Two monocyte-derived factors, interleukin-1 and prostaglandin E2, influence interleukin-2 synthesis with opposite actions. To analyse immunoregulatory function in HBsAg-positive chronic active hepatitis, T ...

journal_title：Journal of hepatology

authors： Civeira M,Prieto J,Morte S,Riñon M,Serrano M

更新日期：1987-08-01 00:00:00