当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Adaptive changes of hepatic bile salt transport in a model of reversible interruption of the enterohepatic circulation in the rat.

Adaptive changes of hepatic bile salt transport in a model of reversible interruption of the enterohepatic circulation in the rat.

Abstract：

:The reversibility and time course of the adaptive changes in hepatic bile salt transport related to modifications of the bile salt enterohepatic circulation and bile salt pool size have not been previously studied. For this reason a model of reversible interruption of entero-hepatic circulation was characterized in unrestrained rats, which allowed the study of changes in hepatic bile salt transport following bile salt pool depletion and subsequent restoration by either the de novo synthesis of bile acids or i.v. administration of exogenous taurocholate. Rats subjected to biliary drainage for 24 h through a transduodenal common bile duct cannula, followed by removal of the cannula and restoration of the enterohepatic circulation were studied at 24, 48 and 72 h. Neither light and electron microscopy examination nor plasma biochemical parameters showed evidence of necrosis, fibrosis, cholestasis or inflammatory changes. Maximum taurocholate secretory rate decreased to 50% following 24-h bile salt depletion. After restoration of the enterohepatic circulation maximum taurocholate secretory rate progressively increased to normal values at 72 h, following the normalization of the bile salt pool size, which had a similar composition compared with controls. The same effect was obtained when the native bile salt pool was substituted with exogenous taurocholate. Thus, adaptive down-regulation of hepatic bile salt transport capacity is a reversible process, related to restoration of entero-hepatic circulation and normalization of bile salt pool size.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Accatino L,Hono J,Koenig C,Pizarro M,Rodriguez L

doi

10.1016/s0168-8278(05)80182-5

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

95-104

issue

1

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(05)80182-5

journal_volume

19

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Severe alpha1-antitrypsin deficiency (PiZ homozygosity) with membranoproliferative glomerulonephritis and nephrotic syndrome, reversible after orthotopic liver transplantation.

    abstract：BACKGROUND/AIMS:Nephropathy associated with alpha1-antitrypsin deficiency is assumed to be an unusual entity. We describe the case of a 23-year-old woman with severe alpha1-antitrypsin (PiZ homozygosity) deficiency who developed hepatic cirrhosis in childhood, and glomerulonephritis and nephrotic syndrome in adult life...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80478-3

    authors： Elzouki AN,Lindgren S,Nilsson S,Veress B,Eriksson S

    更新日期：1997-06-01 00:00:00

  • Longitudinal study on osteodystrophy in primary biliary cirrhosis (PBC) and a pilot study on calcitonin treatment.

    abstract：:The aims of this study were to evaluate bone metabolism in primary biliary cirrhosis (PBC) and the effect of ADFR (activate, depress, free, repeat) therapy with vitamin D, calcium and calcitonin in preventing bone resorption. Sixty-nine female subjects entered the study: 38 PBC (AMA + ve) patients, 11 AMA-negative chr...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90941-4

    authors： Floreani A,Chiaramonte M,Giannini S,Malvasi L,Lodetti MG,Castrignano R,Giacomini A,D'Angelo A,Naccarato R

    更新日期：1991-03-01 00:00:00

  • The relationship of endoscopy, portal Doppler ultrasound flowmetry, and clinical and biochemical tests in cirrhosis.

    abstract：:The relationship of the endoscopic aspect of esophageal varices, portal quantitative Doppler ultrasound parameters and clinical and biochemical findings was assessed in 149 patients with cirrhosis stratified according to the presence of esophageal varices (n = 115) and the absence of previous bleeding (n = 96). In thi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80461-1

    authors： Siringo S,Bolondi L,Gaiani S,Sofia S,Di Febo G,Zironi G,Rigamonti A,Miglioli M,Cavalli G,Barbara L

    更新日期：1994-01-01 00:00:00

  • Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix.

    abstract：BACKGROUND/AIMS:The extracellular matrix plays an essential role in the regulation of cell proliferation in different cell types. However, the regulation of cell cycle control in hepatocytes in response to growth factors and extracellular matrix signals is not well understood. The aims of this study were to investigate...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80401-8

    authors： Nagaki M,Sugiyama A,Naiki T,Ohsawa Y,Moriwaki H

    更新日期：2000-03-01 00:00:00

  • The classification and biological functions of the interferons. A review.

    abstract：:There are three main types of interferon, now designated alpha, beta and gamma. Human interferons-alpha exist as many subtypes, probably more than 26. These are chemically quite closely related, but each has a unique chemical composition and biological properties. Preparations of interferon-alpha derived from stimulat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(86)80115-5

    authors： Finter NB

    更新日期：1986-01-01 00:00:00

  • Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: molecular networks and biological concepts.

    abstract：:Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying the diversity of CCA growth patterns remain a key issue of clinical concern. Crucial questions comp...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2014.09.007

    authors： Raggi C,Invernizzi P,Andersen JB

    更新日期：2015-01-01 00:00:00

  • Deletion of angiotensin II type I receptor reduces hepatic steatosis.

    abstract：BACKGROUND/AIMS:A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of thei...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.01.018

    authors： Nabeshima Y,Tazuma S,Kanno K,Hyogo H,Chayama K

    更新日期：2009-06-01 00:00:00

  • The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure.

    abstract：BACKGROUND/AIMS:Reactive oxygen species, proinflammatory cytokines, glutathione depletion and nitric oxide have all been implicated in the pathogenesis of fulminant hepatic failure. The aim of the present study was to examine the respective roles of these factors in the pathogenesis of thioacetamide-induced fulminant h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80160-3

    authors： Bruck R,Aeed H,Shirin H,Matas Z,Zaidel L,Avni Y,Halpern Z

    更新日期：1999-07-01 00:00:00

  • GBV-C/HGV is not the major cause of autoimmune hepatitis.

    abstract：:Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80306-0

    authors： Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

    更新日期：1996-12-01 00:00:00

  • Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats.

    abstract：BACKGROUND/AIMS:Angiogenesis plays a key role in development of portal hypertension (PHT) and represents a potential therapeutic target. We aimed to evaluate the molecular effects of sorafenib, a multiple tyrosine kinase inhibitor, on splanchnic hemodynamics in rats with partial portal vein ligation (PPVL). METHODS:Th...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.06.024

    authors： Reiberger T,Angermayr B,Schwabl P,Rohr-Udilova N,Mitterhauser M,Gangl A,Peck-Radosavljevic M

    更新日期：2009-11-01 00:00:00

  • Assessment of hepatitis B virus DNA levels in chronic HBsAg carriers with or without hepatitis delta virus superinfection.

    abstract：:In order to document the incidence of hepatitis delta virus (HDV) replication markers and their relationship to HBV replication, 91 HBsAg chronic carriers were studied. Of these, 51 were anti-HD-positive (19 HBeAg-positive and 32 anti-HBe-positive). Liver HDAg was found in 75% of anti-HD-positive patients. Of the 19 p...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(88)80033-3

    authors： Bas C,Bartolomé J,La Banda F,Porres JC,Quiroga JA,Mora I,Carreño V

    更新日期：1988-04-01 00:00:00

  • Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:Macrophages (Mϕ) represent a major component of tumor tissues and play an important role in both tumor progression and therapeutic response. Although tumor Mϕ are generally considered to be derived from circulating monocytes, emerging evidence indicates that tissue Mϕ pools can be maintained by self-r...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.10.021

    authors： Wang J,Wang Y,Chu Y,Li Z,Yu X,Huang Z,Xu J,Zheng L

    更新日期：2020-10-31 00:00:00

  • Alpha-tocopherol deficiency fails to aggravate toxic liver injury but liver injury causes alpha-tocopherol retention.

    abstract：:The possible aggravation of liver injury by impaired cellular antioxidant function was investigated. A vitamin E-deficient diet (0.5 mg/kg alpha-tocopherol; control 100 mg/kg) significantly reduced rat liver alpha-tocopherol concentrations after 4 weeks (1.8 +/- 1.7 micrograms/g; control 34.4 +/- 2.4 micrograms/g, p <...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80665-8

    authors： Barrow L,Patel HR,Tanner MS

    更新日期：1992-11-01 00:00:00

  • Hepatic regeneration in insulin-like growth factor binding protein-1 transgenic mice.

    abstract：BACKGROUND/AIMS:Partial hepatectomy results in activation of genes in the residual liver tissue which serve to restore glucose homeostasis and regenerate liver mass. Expression of insulin-like growth factor binding protein-1 (IGFBP-1) is up-regulated following partial hepatectomy and IGFBP-1 can modulate both the metab...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80199-8

    authors： Liu YY,Rajkumar K,Murphy LJ

    更新日期：1999-04-01 00:00:00

  • Bridging basic science and clinical research: the EASL Monothematic Conference on Translational Research in Viral Hepatitis.

    abstract：:The EASL Monothematic Conference on Translational Research in Viral Hepatitis brought together a group of leading scientists and clinicians working on both, basic and clinical aspects of viral hepatitis, thereby building bridges from bench to bedside. This report recapitulates the presentations and discussions at the ...

    journal_title：Journal of hepatology

    pub_type：

    doi：10.1016/j.jhep.2014.05.016

    authors： Boettler T,Moradpour D,Thimme R,Zoulim F

    更新日期：2014-09-01 00:00:00

  • A diagnostic score for the prediction of spontaneous resolution of acute hepatitis C virus infection.

    abstract：BACKGROUND & AIMS:IL28B polymorphisms, jaundice, decline in HCV-RNA, IP-10, and gender have been proposed to be indicative of spontaneous clearance of acute hepatitis C virus infection. The aim of this study was to define a score enabling the discrimination of patients with spontaneous clearance of HCV from those with ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.06.028

    authors： Beinhardt S,Payer BA,Datz C,Strasser M,Maieron A,Dorn L,Grilnberger-Franz E,Dulic-Lakovic E,Stauber R,Laferl H,Aberle JH,Holzmann H,Krall C,Vogel W,Ferenci P,Hofer H

    更新日期：2013-11-01 00:00:00

  • The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection.

    abstract：BACKGROUND/AIMS:The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis. METHODS:A genotype analysis of CX3CR1 variants was performed in 211 HCV-infect...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.09.008

    authors： Wasmuth HE,Zaldivar MM,Berres ML,Werth A,Scholten D,Hillebrandt S,Tacke F,Schmitz P,Dahl E,Wiederholt T,Hellerbrand C,Berg T,Weiskirchen R,Trautwein C,Lammert F

    更新日期：2008-02-01 00:00:00

  • Ascites from cirrhotic patients induces angiogenesis through the phosphoinositide 3-kinase/Akt signaling pathway.

    abstract：BACKGROUND/AIMS:Ascites in patients with cirrhosis is associated with worsening of systemic hemodynamics. Thus, the aim of this study was to investigate the biological activity of ascites on endothelial cells. METHODS:Human umbilical vein endothelial cells (HUVECs) were used to investigate the angiogenic activity of a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.01.035

    authors： Morales-Ruiz M,Tugues S,Cejudo-Martín P,Ros J,Melgar-Lesmes P,Fernández-Llama P,Arroyo V,Rodés J,Jiménez W

    更新日期：2005-07-01 00:00:00

  • Treatment of concanavalin A-induced hepatitis in mice with low molecular weight heparin.

    abstract：BACKGROUND/AIMS:Heparin has been noted to inhibit inflammation independent of its known anti-coagulant activity. In the present study, we examined the ability of heparin and low molecular weight heparin to prevent immune-mediated, concanavalin A-induced liver damage. METHODS:Mice were pretreated with either heparin or...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(99)80284-0

    authors： Hershkoviz R,Bruck R,Aeed H,Shirin H,Halpern Z

    更新日期：1999-11-01 00:00:00

  • Birth cohort-specific disparities in hepatocellular carcinoma stage at diagnosis, treatment, and long-term survival.

    abstract：BACKGROUND & AIMS:Individuals born between 1945 and 1965 account for nearly 75% of hepatitis C virus (HCV) infections in the United States. As this cohort ages, progressive HCV-related liver disease leading to cirrhosis and hepatocellular carcinoma (HCC) will place a significant burden on the healthcare system. We aim ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.09.006

    authors： Yan M,Ha J,Aguilar M,Bhuket T,Liu B,Gish RG,Cheung R,Wong RJ

    更新日期：2016-02-01 00:00:00

  • Trends in liver transplantation 2011.

    abstract：:This review will highlight some of the important recent trends in liver transplantation. When possible, we will compare and contrast these trends across various regions of the world, in an effort to improve global consensus and better recognition of emerging data. ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/S0168-8278(12)60011-7

    authors： Burra P,Freeman R

    更新日期：2012-01-01 00:00:00

  • Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing.

    abstract：BACKGROUND/AIMS:The aim of our study was to evaluate the proportion of patients with severe alcoholic cirrhosis who would need orthotopic liver transplantation (OLT) and to determine the optimal delay to evaluate an abstinent patient for transplantation. METHODS:Survival without OLT, improvement in liver function and ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00228-8

    authors： Veldt BJ,Lainé F,Guillygomarc'h A,Lauvin L,Boudjema K,Messner M,Brissot P,Deugnier Y,Moirand R

    更新日期：2002-01-01 00:00:00

  • Next-generation sequencing in the diagnosis of non-cirrhotic splanchnic vein thrombosis.

    abstract：BACKGROUND & AIMS:Myeloproliferative neoplasms (MPNs) are the most frequent cause of non-tumoural non-cirrhotic splanchnic vein thrombosis (NC-SVT). Diagnosis of MPN is based on blood cell count alterations, bone marrow histology, and detection of specific gene mutations. Next-generation sequencing (NGS) allows the sim...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.06.045

    authors： Magaz M,Alvarez-Larrán A,Colomer D,López-Guerra M,García-Criado MÁ,Mezzano G,Belmonte E,Olivas P,Soy G,Cervantes F,Darnell A,Ferrusquía-Acosta J,Baiges A,Turon F,Hernández-Gea V,García-Pagán JC

    更新日期：2021-01-01 00:00:00

  • A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure.

    abstract：BACKGROUND & AIMS:Animal models and human case series of acute liver failure (ALF) suggest moderate hypothermia (MH) to have protective effects against cerebral oedema (CO) development and intracranial hypertension (ICH). However, the optimum temperature for patient management is unknown. In a prospective randomized co...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jhep.2016.03.003

    authors： Bernal W,Murphy N,Brown S,Whitehouse T,Bjerring PN,Hauerberg J,Frederiksen HJ,Auzinger G,Wendon J,Larsen FS

    更新日期：2016-08-01 00:00:00

  • Liver stiffness is directly influenced by central venous pressure.

    abstract：BACKGROUND & AIMS:Liver stiffness (LS) as measured by transient elastography [Fibroscan] offers a novel non-invasive approach to assess liver cirrhosis. Since Fibroscan seems to be unreliable in patients with congestive heart failure, it remains to be determined whether hemodynamic changes affect LS irrespective of fib...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2009.11.018

    authors： Millonig G,Friedrich S,Adolf S,Fonouni H,Golriz M,Mehrabi A,Stiefel P,Pöschl G,Büchler MW,Seitz HK,Mueller S

    更新日期：2010-02-01 00:00:00

  • S-adenosylmethionine protects post-ischemic mitochondrial injury in rat liver.

    abstract：BACKGROUND/AIMS:S-adenosylmethionine (SAM) is a thiol-containing compound with known therapeutic affects on cholestasis and hepatotoxicity. The aim of this study was to investigate the effect of SAM on the prevention of mitochondrial injury induced by hepatic ischemia and reperfusion. METHODS/RESULTS:Rats were subject...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00045-3

    authors： Jeon BR,Lee SM

    更新日期：2001-03-01 00:00:00

  • Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.

    abstract：BACKGROUND/AIMS:The precise mechanism of formation and significance of Mallory bodies (MBs) are poorly understood. The endoplasmic reticulum (ER) is the organelle responsible for proper folding and elimination of unfolded proteins. Therefore, failure of this function increases defective proteins in the cell. METHODS:W...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2007.01.039

    authors： Hanada S,Harada M,Kumemura H,Bishr Omary M,Koga H,Kawaguchi T,Taniguchi E,Yoshida T,Hisamoto T,Yanagimoto C,Maeyama M,Ueno T,Sata M

    更新日期：2007-07-01 00:00:00

  • Hepatitis B: reflections on the current approach to antiviral therapy.

    abstract：:This article summarizes the current state of antiviral therapy of hepatitis B with special attention given to areas that remain controversial or poorly defined. Strict adherence to liver association practice guidelines may result in missed opportunities to treat patients with significant underlying liver disease. In p...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2008.01.011

    authors： Zoulim F,Perrillo R

    更新日期：2008-01-01 00:00:00

  • Gene expression regulation for interferon-alpha in hepatocellular carcinoma.

    abstract：:We investigated whether regulation of interferon-alpha gene expression could be involved in liver tumor biology and the role, if any, of hepatitis B virus in the regulation of tumor cytokine gene expression. Gene expression was investigated at the transcriptional level using 'in situ' hybridization of cytokine message...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80215-6

    authors： d'Arville CN,Nouri-Aria KT,Johnson P,Williams R

    更新日期：1993-03-01 00:00:00

  • Pulmonary contraindications, indications and MELD exceptions for liver transplantation: a contemporary view and look forward.

    abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2013.03.026

    authors： Krowka MJ,Wiesner RH,Heimbach JK

    更新日期：2013-08-01 00:00:00