Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: molecular networks and biological concepts.

abstract：BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

journal_title：Journal of hepatology

authors： Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acyclic retinoid (AR; all trans-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid) prevented hepatocarcinogenesis in animal models and in a randomized clinical trial by eradicating premalignant and latent malignant clones of transformed cells from the liver. We investigated the possible mechanis...

journal_title：Journal of hepatology

authors： Yasuda I,Shiratori Y,Adachi S,Obora A,Takemura M,Okuno M,Shidoji Y,Seishima M,Muto Y,Moriwaki H

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND & AIMS:Although antiviral treatment for hepatitis C (HCV) is highly effective, side effects often occur, including weight loss, digestive symptoms, and impaired quality of life. We aimed at exploring the beneficial effects of preventive nutritional support. METHODS:In a randomized controlled trial, 53 HCV p...

journal_title：Journal of hepatology

authors： Huisman EJ,van Hoek B,van Soest H,van Nieuwkerk KM,Arends JE,Siersema PD,van Erpecum KJ

更新日期：2012-11-01 00:00:00

abstract：:All routinely available assays to detect hepatitis C virus (HCV) infection are based on the specific reaction of serum antibodies to corresponding viral antigens. The only method to detect viral nucleic acids in serum or liver is the enzymatic amplification of reversely transcribed HCV-RNA by polymerase chain reaction...

journal_title：Journal of hepatology

authors： Geiger CP,Caselmann WH

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:There is no data to suggest that the size of bile ducts, portal venules, and hepatic arterioles varies according to age in the normal human liver. We sought to examine whether hepatic arteriolar size, wall thickness, and luminal diameter change with increasing age. METHODS:Histologically normal liver...

journal_title：Journal of hepatology

authors： Fiel MI,Deniz K,Elmali F,Schiano TD

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIMS:IgM antibodies to hepatitis C virus have been found in a variable proportion of patients with chronic hepatitis C. We have evaluated whether IgM anti-core antibodies correlate with viraemia or hepatic injury in chronic hepatitis C. METHODS:Serum from 106 patients with chronic hepatitis C with varying s...

journal_title：Journal of hepatology

authors： Martinelli AL,Brown D,Braun HB,Michel G,Dusheiko GM

更新日期：1996-01-01 00:00:00

abstract：:Experimental autoimmune hepatitis was induced in C57BL/6 mice by immunization with syngeneic liver protein and adjuvant. Hepatitis was characterized by marked cellular infiltrates, but hepatic necrosis was mild to moderate. A small dose of endotoxin (25 micrograms/mouse) produced lethal hepatitis with elevation of ser...

journal_title：Journal of hepatology

authors： Ogawa M,Mori Y,Ueda S,Mori T,Makino Y,Hori J,Ohto M,Wakashin M

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alco...

journal_title：Journal of hepatology

authors： Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND & AIMS:Liver failure is associated with progressive cytotoxic brain oedema (astrocyte swelling), which underlies hepatic encephalopathy (HE). Ammonia and superimposed inflammation are key synergistic factors in HE, but the mechanism(s) involved remain unknown. We aimed to determine whether aquaporin-4 (AQP4)...

journal_title：Journal of hepatology

authors： Wright G,Soper R,Brooks HF,Stadlbauer V,Vairappan B,Davies NA,Andreola F,Hodges S,Moss RF,Davies DC,Jalan R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatitis C virus (HCV) has been recognized as a major cause of liver disease, but little is known about its diffusion at population level. To estimate the prevalence and incidence of HCV infection and to explore potential risk factors at population level, an epidemiologic study was carried out. METHOD...

journal_title：Journal of hepatology

authors： Osella AR,Misciagna G,Leone A,Di Leo A,Fiore G

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIMS:Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder characterized by reduced plasma levels of low-density lipoproteins. It can be caused by mutations in the gene encoding apolipoprotein B-100 (apo B), leading to the formation of truncated apo Bs which have a reduced capacity to export lipi...

journal_title：Journal of hepatology

authors： Tarugi P,Lonardo A,Ballarini G,Erspamer L,Tondelli E,Bertolini S,Calandra S

更新日期：2000-09-01 00:00:00

abstract：:The ischemic biliary phenotype of hereditary hemorrhagic telangiectasia (HHT) is rare but distinct, with progressive biliary tree ischemia usually resulting in an irreversible secondary sclerosing cholangiopathy. When clinically severe, liver transplant is often indicated. We report three patients with marked HHT asso...

journal_title：Journal of hepatology

authors： Vlachou PA,Colak E,Koculym A,Kirpalani A,Kim TK,Hirschfield GM,Faughnan ME

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND & AIMS:Clinical cases of viral infections possibly involving the transfusion of blood components are systematically investigated. METHODS:Serological and molecular markers of hepatitis B virus were used including HBsAg, anti-HBc, anti-HBs, HBV DNA, and viral load. Full genome sequencing and phylogenetic ana...

journal_title：Journal of hepatology

authors： Niederhauser C,Candotti D,Weingand T,Maier A,Tinguely C,Stolz M,Allain JP

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis C virus (HCV) infection and cirrhosis have a higher risk for liver-related complications and have historically been more difficult to cure than patients without cirrhosis. We evaluated the safety and efficacy of ombitasvir/paritaprevir/ritonavir and dasabuvir, without r...

journal_title：Journal of hepatology

authors： Feld JJ,Moreno C,Trinh R,Tam E,Bourgeois S,Horsmans Y,Elkhashab M,Bernstein DE,Younes Z,Reindollar RW,Larsen L,Fu B,Howieson K,Polepally AR,Pangerl A,Shulman NS,Poordad F

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:Neonatal sclerosing cholangitis (NSC) is a severe neonatal-onset cholangiopathy commonly leading to liver transplantation (LT) for end-stage liver disease in childhood. Liver biopsy findings histopathologically resemble those in biliary atresia (BA); however, in NSC extrahepatic bile ducts are patent,...

journal_title：Journal of hepatology

authors： Grammatikopoulos T,Sambrotta M,Strautnieks S,Foskett P,Knisely AS,Wagner B,Deheragoda M,Starling C,Mieli-Vergani G,Smith J,University of Washington Center for Mendelian Genomics.,Bull L,Thompson RJ

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...

journal_title：Journal of hepatology

authors： Garcia-Tsao G,Bosch J,Kayali Z,Harrison SA,Abdelmalek MF,Lawitz E,Satapathy SK,Ghabril M,Shiffman ML,Younes ZH,Thuluvath PJ,Berzigotti A,Albillos A,Robinson JM,Hagerty DT,Chan JL,Sanyal AJ,IDN-6556-14 Investigators(‡).

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AIMS:In hepatitis C there is controversy over the linearity of the rate of progression and the significance of gender, mode of infection and viral factors. METHODS:2313 untreated patients with a reliable estimated duration of infection and liver fibrosis were included. Fibrosis progression was calculated us...

journal_title：Journal of hepatology

authors： Poynard T,Ratziu V,Charlotte F,Goodman Z,McHutchison J,Albrecht J

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND & AIMS:Non alcoholic steatohepatitis (NASH) has no approved pharmacological therapy. Insulin sensitisers such as thiazolidinediones ameliorate insulin resistance and are a potential therapeutic option. We performed a systematic review and meta-analysis of the effect of thiazolidinediones on histological and ...

journal_title：Journal of hepatology

authors： Mahady SE,Webster AC,Walker S,Sanyal A,George J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIM:Primary biliary cirrhosis (PBC) is an autoimmune cholestatic liver disease thought to develop through a complex interaction of genetic and environmental factors. It is characterised by T-cell-mediated non-suppurative destructive cholangitis. We have studied the polymorphic cytotoxic T lymphocyte-associat...

journal_title：Journal of hepatology

authors： Agarwal K,Jones DE,Daly AK,James OF,Vaidya B,Pearce S,Bassendine MF

更新日期：2000-04-01 00:00:00

abstract：:The First European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV Co-infected Patients aimed to produce recommendations that could be applied across Europe. However, some important differences exist around Europe, in terms of access to treatment and tests for monitoring. This short survey of...

journal_title：Journal of hepatology

authors： Salmon D,Robain M,Rockstroh JK,Benhamou Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell (HSC) transdifferentiation into collagen-producing myofibroblasts is a key event in hepatic fibrogenesis, but the transcriptional network that controls the acquisition of the activated phenotype is still poorly understood. In this study, we explored whether the nuclear receptor c...

journal_title：Journal of hepatology

authors： Ceni E,Mello T,Polvani S,Vasseur-Cognet M,Tarocchi M,Tempesti S,Cavalieri D,Beltrame L,Marroncini G,Pinzani M,Milani S,Galli A

更新日期：2017-04-01 00:00:00

abstract：:Calcium concentrations in pig livers were serially estimated following ischemia-reperfusion. Ischemia was produced by clamping the hepatic artery and the portal vein for 90 min (Group 1, n = 6) or for 180 min (Group 2, n = 6) during temporary side-to-side portacaval shunt performed before the induction of ischemia. Al...

journal_title：Journal of hepatology

authors： Uchida M,Takemoto Y,Nagasue N,Kimoto T,Dhar DK,Nakamura T

更新日期：1994-06-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. Increasing recognition of the importance of NAFLD and its association with the features of the metabolic syndrome has stimulated an interest in its putative role in the development and progression of chronic kidney dise...

journal_title：Journal of hepatology

authors： Targher G,Chonchol M,Zoppini G,Abaterusso C,Bonora E

更新日期：2011-05-01 00:00:00

abstract：:Medical treatment of cirrhotic ascites is essentially supportive, dictated by the patient's discomfort, impaired cardiovascular or respiratory function and potential for infection. Treatment of 'simple' ascites (moderate fluid accumulation, serum albumin > 3.5 g/dl, serum creatinine < 1.5 mg/dl, no electrolyte disturb...

journal_title：Journal of hepatology

authors： Gerbes AL

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aims were to study: 1) the prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic liver disease, 2) viral and host immunogenetic factors that may predispose to diabetes, and 3) liver transplantation outcome in patients with or without d...

journal_title：Journal of hepatology

authors： Zein NN,Abdulkarim AS,Wiesner RH,Egan KS,Persing DH

更新日期：2000-02-01 00:00:00

abstract：:The multidrug resistance genes encode plasma membrane glycoproteins named P-glycoproteins, that act as an ATP-dependent drug efflux pump and decrease the cytosolic concentration of chemotherapeutic agents. It has been hypothesized that in rat liver, this protein may have a physiological role as a biliary transporter o...

journal_title：Journal of hepatology

authors： Vollrath V,Wielandt AM,Acuña C,Duarte I,Andrade L,Chianale J

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

journal_title：Journal of hepatology

authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND & AIMS:To follow the local tissue delivery of doxorubicin in HCC explants from patients embolized with drug-eluting beads and to compare it with histologic modifications. METHODS:Six patients with HCC underwent chemoembolization with doxorubicin-eluting beads (caliber 100-300 μm, dose 75-150 mg) followed by...

journal_title：Journal of hepatology

authors： Namur J,Citron SJ,Sellers MT,Dupuis MH,Wassef M,Manfait M,Laurent A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary co-fac...

journal_title：Journal of hepatology

authors： Keshavarzian A,Farhadi A,Forsyth CB,Rangan J,Jakate S,Shaikh M,Banan A,Fields JZ

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND & AIMS:Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC(3) included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNα-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. METHO...

journal_title：Journal of hepatology

authors： Poynard T,Bruix J,Schiff ER,Diago M,Berg T,Moreno-Otero R,Lyra AC,Carrilho F,Griffel LH,Boparai N,Jiang R,Burroughs M,Brass CA,Albrecht JK

更新日期：2013-03-01 00:00:00