当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.

Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.

Abstract：

BACKGROUND & AIMS:Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alcoholic steatohepatitis (NASH). Our aim was to investigate the factors associated with NASH in children and adolescents with proven NAFLD, and to test whether UA concentrations and fructose consumption are independently associated with NASH. METHODS:Obese children with NAFLD were studied (n=271). NASH was diagnosed by a NAFLD activity score ⩾5 and the fatty liver inhibition of progression (FLIP) algorithm. Fructose consumption (g/day) was assessed by food frequency questionnaire, and UA (mg/dl) was measured in serum. Binary logistic regression with adjustment for covariates and potential confounders was undertaken to test factors independently associated with NASH. RESULTS:NASH occurred in 37.6% of patients. Hyperuricaemia (UA ⩾5.9mg/dl) was present in 47% of patients with NASH compared with 29.7% of non-NASH patients (p=0.003). Both UA concentration (OR=2.488, 95% CI: 1.87-2.83, p=0.004) and fructose consumption (OR=1.612, 95% CI 1.25-1.86, p=0.001) were independently associated with NASH, after adjustment for multiple (and all) measured confounders. Fructose consumption was independently associated with hyperuricaemia (OR=2.021, 95% CI: 1.66-2.78, p=0.01). These data were confirmed using the FLIP algorithm. CONCLUSIONS:Both dietary fructose consumption and serum UA concentrations are independently associated with NASH. Fructose consumption was the only factor independently associated with serum UA concentration. LAY SUMMARY:Currently, it is not known whether dietary fructose consumption and uric acid (UA) concentration are linked with non-alcoholic steatohepatitis (NASH) in children and adolescents. Our aim was to test whether UA concentrations and fructose consumption are independently associated with NASH in children and adolescents with proven non-alcoholic fatty liver disease (NAFLD). We show that both dietary fructose consumption and serum UA concentrations are independently associated with NASH and fructose consumption was independently linked with high serum UA concentrations.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Mosca A,Nobili V,De Vito R,Crudele A,Scorletti E,Villani A,Alisi A,Byrne CD

doi

10.1016/j.jhep.2016.12.025

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

1031-1036

issue

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(17)30002-8

journal_volume

pub_type

杂志文章

在线工具

Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.