Dynamics of the vascular profile of the finer branches of the biliary tree in normal and diseased human livers.


BACKGROUND/AIMS:Results of our previous studies supported the concept that in the human liver, the smallest ramification of the biliary tree, the bile ductules, might contain hepatic progenitor cells. An insufficient proliferative response and loss of bile ductules preceded bile duct loss whereas preservation of bile ductules mitigated bile duct loss. METHODS:Presently we investigated the vascular profile of the bile ductules in diseased human livers and livers showing normal histological features as controls, using CD34, CK7 and alphaSMA antibodies in a double immunolabeling technique. VEGF-A expression was also studied. In control livers bile ductules traversed the boundaries of the portal tract into the lobule as ductular-vascular units, in a pattern outlining the classic hexagonal lobule, following the vascular septa. The latter are thought to be extensions of portal veins. In diseased states the two structures reacted in unison. Increased or decreased numbers of ductules were consistently accompanied by similar changes of accompanying microvessels. Increased numbers of ductules and microvessels were paralleled by increased ductular expression of VEGF-A. RESULTS:Our data support the concept that the smallest branches of the biliary tree might have their own vascular supply and that the ductules might in turn maintain their vasculature during regenerative processes.


J Hepatol


Journal of hepatology


Gouw AS,van den Heuvel MC,Boot M,Slooff MJ,Poppema S,de Jong KP




Has Abstract


2006-09-01 00:00:00














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  • Association between elevated coffee consumption and daily chocolate intake with normal liver enzymes in HIV-HCV infected individuals: results from the ANRS CO13 HEPAVIH cohort study.

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    pub_type: 杂志文章


    authors: Carrieri MP,Lions C,Sogni P,Winnock M,Roux P,Mora M,Bonnard P,Salmon D,Dabis F,Spire B,ANRS CO13 HEPAVIH Study Group.

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  • Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment.

    abstract::Hepatitis B virus (HBV) variants with a stop codon, a mutated translation initiation codon or other mutations in the pre-C region which prevent e-antigen expression are highly prevalent in anti-HBe chronic carriers and can be positively selected from a mixed virus infection. Our laboratories recently described pre-C v...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Santantonio T,Jung MC,Schneider R,Pastore G,Pape GR,Will H

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    abstract:BACKGROUND/AIMS:Bio-artificial liver support systems for treatment of hepatic failure require maintained expression of hepatocyte function in vitro. We studied cultures of human hepatocyte cell-lines proliferating within alginate beads, investigating the hypothesis that 3-dimensional cohesive colonies of hepatocyte cel...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Khalil M,Shariat-Panahi A,Tootle R,Ryder T,McCloskey P,Roberts E,Hodgson H,Selden C

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  • Infection with a novel human DNA virus (TTV) has no pathogenic significance in patients with liver diseases.

    abstract:BACKGROUND/AIMS:A recently identified DNA virus, termed TT virus (TTV), has been associated with post-transfusional hepatitis, and a high prevalence of TTV infection in patients with acute or chronic liver disease of unknown etiology has been reported from Japan, but few data are available about TTV infection in other ...

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    pub_type: 杂志文章


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    authors: Igolnikov AC,Green RM

    更新日期:2006-03-01 00:00:00

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    authors: Mourelle M,Salas A,Vilaseca J,Guarner F,Malagelada JR

    更新日期:1995-02-01 00:00:00

  • Hepatic oxidant and antioxidant systems in portacaval-shunted rats.

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    authors: Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

    更新日期:1992-03-01 00:00:00

  • Prognostic impact of surgery and radiofrequency ablation on single nodular HCC ⩽5 cm: Cohort study based on serum HCC markers.

    abstract:BACKGROUND & AIMS:Serological markers of hepatocellular carcinoma (HCC) indicate its invasiveness. We aimed to investigate whether the prognostic impact of surgical resection (SR) and radiofrequency thermal ablation (RFA) on patients with single nodular HCC ⩽5cm were different regarding positive conditions of the follo...

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    更新日期:2015-12-01 00:00:00

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    更新日期:2013-06-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Hernando V,Perez-Cachafeiro S,Lewden C,Gonzalez J,Segura F,Oteo JA,Rubio R,Dalmau D,Moreno S,Amo JD,CoRIS.

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    authors: Halfon P,Bacq Y,De Muret A,Penaranda G,Bourliere M,Ouzan D,Tran A,Botta D,Renou C,Bréchot MC,Degott C,Paradis V

    更新日期:2007-03-01 00:00:00

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    authors: Lunel F,Cacoub P

    更新日期:1999-01-01 00:00:00

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    更新日期:2017-03-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章,meta分析


    authors: McPhail MJ,Wendon JA,Bernal W

    更新日期:2010-09-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Moldovan B,Mentha G,Majno P,Berney T,Morard I,Giostra E,Wildhaber BE,Van Delden C,Morel P,Toso C

    更新日期:2011-12-01 00:00:00

  • Liver biopsy in liver transplantation: no additional risk of infections in patients with choledochojejunostomy.

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ben-Ari Z,Neville L,Rolles K,Davidson B,Burroughs AK

    更新日期:1996-03-01 00:00:00

  • Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon.

    abstract::alpha-Interferon therapy normalizes aminotransferase levels in approximately 50% of the patients with chronic hepatitis C, but post-therapy relapses are common and predictive factors of sustained response remain largely unknown. We retrospectively assessed several parameters as predictors of sustained remission after ...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Camps J,García-Granero M,Riezu-Boj JI,Larrea E,de Alava E,Civeira MP,Castilla A,Prieto J

    更新日期:1994-07-01 00:00:00

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Dubuisson L,Lepreux S,Bioulac-Sage P,Balabaud C,Costa AM,Rosenbaum J,Desmoulière A

    更新日期:2001-04-01 00:00:00

  • Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma.

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    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Peng SY,Chou SP,Hsu HC

    更新日期:1998-08-01 00:00:00

  • Prognostic relevance of serum inhibitory factors (SIF) in protracted and persistent hepatitis B.

    abstract::In a follow-up study of 3 years' duration, serum inhibitory factors (SIF) were analysed in 23 patients with a protracted course of viral hepatitis B (PVH) and 12 patients with chronic persistent hepatitis (CPH). Four patients showed a progressive course, developing chronic active hepatitis, and one died of liver failu...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Brattig NW,Ortmans H,Wildhirt W,Klinge O,Berg PA

    更新日期:1987-04-01 00:00:00