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Interleukin-15 increases hepatic regenerative activity.

Abstract：

BACKGROUND/AIMS:Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity. METHODS:Expression of IL-15 and its receptors was evaluated in several liver injury models, primary hepatocytes, and two liver cell lines. Effects of IL-15 on viability, proliferation, and apoptosis were assessed in cultured liver cells, and also in the livers of healthy mice. RESULTS:IL-15 and its receptors are expressed constitutively in healthy livers, and ligand expression is induced in injured livers. Cultured primary hepatocytes and liver cell lines express IL-15 and its receptors. Administration of IL-15 has minimal effects on cultured liver cells, but significantly up-regulates oval cell accumulation, cyclin mRNA expression, and mature hepatocyte replication in healthy mice. These effects are associated with focal hepatic inflammation and increased expression of TNF-alpha and IFN-gamma, but not with increased cell death or aminotransferase release. CONCLUSIONS:IL-15 expression increases during liver injury and IL-15 treatment induces a wound healing-type response in healthy adult mice. These findings suggest that IL-15 may contribute to regenerative activity in damaged liver.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Suzuki A,McCall S,Choi SS,Sicklick JK,Huang J,Qi Y,Zdanowicz M,Camp T,Li YX,Diehl AM

doi

10.1016/j.jhep.2006.04.008

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

410-8

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(06)00241-8

journal_volume

45

pub_type

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