当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > Alcohol in combination with malnutrition causes increased liver fibrosis in rats.

Alcohol in combination with malnutrition causes increased liver fibrosis in rats.

Abstract：

:Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in drinking water available ad libitum, the livers of all eight rats showed increased fibrosis and cirrhosis as compared to the livers of the eight non-alcohol-treated, isocalorically fed, paired control rats. Alcohol-treated rats developed fibrosis and cirrhosis on a dietary fat content of 38% of total caloric intake and low blood alcohol levels, ranging from 50 to 126 mg/dl, due to gradual intake over the day and to low absolute intake (mean 11.9 +/- 0.6 g/kg per day). None of the rats died spontaneously. Malnutrition is likely to be an important factor in the development of the fibrosis of alcoholic liver disease, and this rat model may be used to study aspects of the pathogenesis.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Bosma A,Seifert WF,van Thiel-de Ruiter GC,van Leeuwen RE,Blauw B,Roholl P,Knook DL,Brouwer A

doi

10.1016/s0168-8278(05)80319-8

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

394-402

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(05)80319-8

journal_volume

21

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • Quality of life and cognitive function in hepatitis C at different stages of liver disease.

    abstract：BACKGROUND/AIMS:Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function. METHODS:Quality of life, clinical variables and neuropsychological function were evaluated in ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00189-2

    authors： Córdoba J,Flavià M,Jacas C,Sauleda S,Esteban JI,Vargas V,Esteban R,Guardia J

    更新日期：2003-08-01 00:00:00

  • Arsenic and non-cirrhotic portal hypertension. A report of eight cases.

    abstract：:It was discovered that eight patients with complications of non-cirrhotic portal hypertension had received an arsenical preparation for psoriasis as Fowler's solution some years age. Seven of them were admitted for bleeding oesophageal varices. Upon admission, splenomegaly and hypersplenism were present. Liver tests w...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(90)90276-w

    authors： Nevens F,Fevery J,Van Steenbergen W,Sciot R,Desmet V,De Groote J

    更新日期：1990-07-01 00:00:00

  • Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma.

    abstract：BACKGROUND & AIMS:The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and develop...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.12.014

    authors： Dong LQ,Peng LH,Ma LJ,Liu DB,Zhang S,Luo SZ,Rao JH,Zhu HW,Yang SX,Xi SJ,Chen M,Xie FF,Li FQ,Li WH,Ye C,Lin LY,Wang YJ,Wang XY,Gao DM,Zhou H,Yang HM,Wang J,Zhu SD,Wang XD,Cao Y,Zhou J,Fan J,Wu K,Gao

    更新日期：2020-05-01 00:00:00

  • Temporary heterotopic auxiliary liver transplantation for fulminant hepatitis B.

    abstract：BACKGROUND/AIMS:Orthotopic liver transplantation has been shown to improve survival in fulminant hepatic failure. However, after orthotopic liver transplantation life-long immunosuppression is necessary and graft complications may occur. METHODS:We employed heterotopic auxiliary liver transplantation in a 26-year-old ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80323-8

    authors： van Hoek B,Ringers J,Kroes AC,van Krieken JH,van Schelven WD,Masclee AA,van Krikken-Hogenberk LG,Haak HR,Lamers CB,Terpstra OT

    更新日期：1995-08-01 00:00:00

  • Comparison of no-touch multi-bipolar vs. monopolar radiofrequency ablation for small HCC.

    abstract：BACKGROUND & AIMS:The primary aim of this study was to compare the rate of global radiofrequency ablation (RFA) failure between monopolar RFA (MonoRFA) vs. no-touch multi-bipolar RFA (NTmbpRFA) for small hepatocellular carcinoma (HCC) ⩽5cm in cirrhotic patients. METHODS:A total of 362 cirrhotic patients were included ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jhep.2016.07.010

    authors： Hocquelet A,Aubé C,Rode A,Cartier V,Sutter O,Manichon AF,Boursier J,N'kontchou G,Merle P,Blanc JF,Trillaud H,Seror O

    更新日期：2017-01-01 00:00:00

  • Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma.

    abstract：BACKGROUND/AIMS:Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior. METHODS:In this study, genome-wide aberrations in 13 cases of cholan...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(02)00269-6

    authors： Wong N,Li L,Tsang K,Lai PB,To KF,Johnson PJ

    更新日期：2002-11-01 00:00:00

  • Molecular virology of the hepatitis C virus.

    abstract：:Infection with the hepatitis C virus (HCV) is the major cause of nonA-nonB hepatitis worldwide. Although this virus cannot be cultivated in vitro, several of its key features have been elucidated in the past few years. The viral genome is a positive-sense, single-stranded, 9.6 kb long RNA molecule. The viral genome is...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(99)80374-2

    authors： De Francesco R

    更新日期：1999-01-01 00:00:00

  • The new therapeutic frontier--nuclear receptors and the liver.

    abstract：:A joint EASL/AASLD Monothematic Conference on 'Nuclear Receptors and Liver Disease' was held from February 27th to March 1st, 2009, in Vienna, Austria, to discuss the latest advances at the forefront of basic and clinical nuclear receptor research and its potential implications for liver diseases. This article reports...

    journal_title：Journal of hepatology

    pub_type：

    doi：10.1016/j.jhep.2009.12.002

    authors： Karpen SJ,Trauner M

    更新日期：2010-03-01 00:00:00

  • Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs. METHODS:Chimeric mice transplanted with donor BM from collagen alpha1(I)-GFP+ reporter mice were subjected...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.04.014

    authors： Kisseleva T,Uchinami H,Feirt N,Quintana-Bustamante O,Segovia JC,Schwabe RF,Brenner DA

    更新日期：2006-09-01 00:00:00

  • Metabolic activity of microcarrier attached liver cells after intraperitoneal transplantation during severe liver insufficiency in the rat.

    abstract：:Short- and long-term effects of intraperitoneally transplanted microcarrier attached liver cells (MAL) have been studied in two experimental models of severe liver insufficiency in the rat: subtotal hepatectomy (HX) and acute liver ischemia. Intraperitoneal transplantation of MAL immediately after subtotal hepatectomy...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(89)90075-5

    authors： Bosman DK,de Haan JG,Smit J,Jorning GG,Maas MA,Chamuleau RA

    更新日期：1989-07-01 00:00:00

  • Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility.

    abstract：BACKGROUND/AIMS:Hepatic stellate cells (HSCs) are perisinusoidal pericytes which have receptors for vasoactive factors, such as endothelin-1, which can regulate cell contractility in an autocrine manner. It is unknown whether human HSCs have receptors for and are able to synthesize the vasodilator peptide adrenomedulli...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)00016-7

    authors： Görbig MN,Ginès P,Bataller R,Nicolás JM,Garcia-Ramallo E,Cejudo P,Sancho-Bru P,Jiménez W,Arroyo V,Rodés J

    更新日期：2001-02-01 00:00:00

  • Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection.

    abstract：BACKGROUND & AIMS:HCV requires host lipid metabolism for replication, and apolipoproteins have been implicated in the response to treatment. METHODS:We examined plasma apolipoprotein concentrations in three cohorts of patients: mono-infected patients with symptomatic acute hepatitis C (aHCV); those undergoing treatmen...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.05.040

    authors： Laird ME,Mohsen A,Duffy D,Mamdouh R,LeFouler L,Casrouge A,El-Daly M,Rafik M,Abdel-Hamid M,Soulier A,Pawlotsky JM,Hézode C,Rosa I,Renard P,Mohamed MK,Bonnard P,Izopet J,Mallet V,Pol S,Albert ML,Fontanet A

    更新日期：2014-10-01 00:00:00

  • An outbreak of hepatitis A virus infection with a high case-fatality rate among injecting drug users.

    abstract：BACKGROUND/AIMS:In 2002, the first reported outbreak of hepatitis A virus (HAV) infection involving mostly intravenous drug users (IDU) occurred in Italy. We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses. METHODS:We conducted an epidemiological investigat...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.06.012

    authors： Spada E,Genovese D,Tosti ME,Mariano A,Cuccuini M,Proietti L,Giuli CD,Lavagna A,Crapa GE,Morace G,Taffon S,Mele A,Rezza G,Rapicetta M

    更新日期：2005-12-01 00:00:00

  • Caspase-dependent apoptosis in fulminant hepatic failure induced by herpes simplex virus in mice.

    abstract：BACKGROUND/AIMS:Herpes simplex virus (HSV) is known to induce fulminant hepatic failure. The aim of this study is to clarify the molecular basis of liver injury in HSV-induced hepatitis. METHODS:Immunocompetent mice were inoculated with HSV or ultraviolet-inactivated HSV (UV-HSV) intravenously. Extent of liver injury ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00385-4

    authors： Hashimoto K,Minagawa H,Yanagi Y

    更新日期：2003-11-01 00:00:00

  • Quantitative analysis of IgM anti-HBc in chronic hepatitis B patients using a new "gray-zone" for the evaluation of "borderline" values.

    abstract：BACKGROUND/METHODS:In order to define the clinical significance of borderline levels of IgM anti-HBc in chronic hepatitis B patients, we followed up 89 untreated hepatitis B patients (19 HBeAg pos and 70 anti-HBe pos) for 1 year, with monthly monitoring of IgM anti-HBc using a highly sensitive quantitative microparticl...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(96)80233-9

    authors： Colloredo G,Bellati G,Leandro G,Colombatto P,Rho A,Bissoli F,Brunetto MR,Angeli G,Ideo G,Bonino F

    更新日期：1996-11-01 00:00:00

  • Choosing the best endpoint.

    abstract：:Design and endpoints of clinical trials in hepatocellular carcinoma. Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J, Gores GJ; for the Panel of Experts in HCC-Design Clinical Trials. The design of clinical trials in hepatocellular carcinoma (HCC) is comp...

    journal_title：Journal of hepatology

    pub_type： 评论,杂志文章

    doi：10.1016/j.jhep.2008.07.012

    authors： Christensen E

    更新日期：2008-10-01 00:00:00

  • A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

    abstract：BACKGROUND & AIMS:We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC). METHODS:A total of 682 HCV-induced LC cases and 1045 CHC patients of Japanese origin were genoty...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.12.024

    authors： Urabe Y,Ochi H,Kato N,Kumar V,Takahashi A,Muroyama R,Hosono N,Otsuka M,Tateishi R,Lo PH,Tanikawa C,Omata M,Koike K,Miki D,Abe H,Kamatani N,Toyota J,Kumada H,Kubo M,Chayama K,Nakamura Y,Matsuda K

    更新日期：2013-05-01 00:00:00

  • Modulation of collagen XVIII/endostatin expression in lobular and biliary rat liver fibrogenesis.

    abstract：BACKGROUND/AIMS:The liver is the major source of collagen XVIII (C18), the precursor of the angiogenesis inhibitor endostatin. In human liver C18 is mainly expressed by hepatocytes. However, its quantitative and temporospatial expression patterns during liver fibrogenesis are unknown. METHODS:We used RNA quantificatio...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00134-9

    authors： Jia JD,Bauer M,Sedlaczek N,Herbst H,Ruehl M,Hahn EG,Riecken EO,Schuppan D

    更新日期：2001-09-01 00:00:00

  • Long-term follow-up of chronic hepatitis C in patients diagnosed at a tertiary-care center.

    abstract：BACKGROUND/AIMS:The natural history of chronic hepatitis C (HCV) is not completely understood. This study was aimed to evaluate the long-term outcome of the disease over a prolonged period of time and to identify factors associated with progression. METHODS:One hundred and sixteen patients with non-cirrhotic chronic n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00088-5

    authors： Forns X,Ampurdanès S,Sanchez-Tapias JM,Guilera M,Sans M,Sánchez-Fueyo A,Quintó L,Joya P,Bruguera M,Rodés J

    更新日期：2001-08-01 00:00:00

  • Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

    abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into t...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2020.11.024

    authors： Bianco C,Jamialahmadi O,Pelusi S,Baselli G,Dongiovanni P,Zanoni I,Santoro L,Maier S,Liguori A,Meroni M,Borroni V,D'Ambrosio R,Spagnuolo R,Alisi A,Federico A,Bugianesi E,Petta S,Miele L,Vespasiani-Gentilucci U,Anstee

    更新日期：2020-11-25 00:00:00

  • Mechanism of hepatic fatty acid uptake.

    abstract：:In recent years a new concept of the mechanism of hepatic fatty acid uptake has been described. It was shown that this major class of energy yielding substrates enters hepatocytes by a carrier-mediated uptake system. After the dissociation of the fatty acid-albumin complex at the sinusoidal liver cell plasma membrane,...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8278(89)90148-7

    authors： Stremmel W

    更新日期：1989-11-01 00:00:00

  • Elevated levels of serum carbohydrate deficient transferrin are not specific for alcohol abuse in patients with liver disease.

    abstract：BACKGROUND:Serum carbohydrate deficient transferrin is a marker of chronic alcohol consumption; it increases above normal in healthy individuals after a daily alcohol intake of more than 60 g/d for more than 2 weeks. The influence of liver disease itself on carbohydrate deficient transferrin levels has not been suffici...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(95)80037-9

    authors： Radosavljevic M,Temsch E,Hammer J,Pfeffel F,Mayer G,Renner F,Pidlich J,Muller C

    更新日期：1995-12-01 00:00:00

  • Viral and metabolic factors influencing alanine aminotransferase activity in patients with chronic hepatitis C.

    abstract：BACKGROUND/AIMS:In chronic hepatitis C, disease progression and clinical manifestations are heterogenous. To clarify the role and interactions of viral and host factors in inducing liver cell injury, we examined the associations of several virological and metabolic variables with serum alanine aminotransferase levels. ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2006.01.004

    authors： Prati D,Shiffman ML,Diago M,Gane E,Rajender Reddy K,Pockros P,Farci P,O'Brien CB,Lardelli P,Blotner S,Zeuzem S

    更新日期：2006-04-01 00:00:00

  • Pattern of HCV antibodies with special reference to NS5A reactivity in HCV-infected patients: relation to viral genotype, cryoglobulinemia and response to interferon.

    abstract：BACKGROUND/AIMS:We aimed to compare the anti-hepatitis C virus reactivity in confirmatory assays (RIBA 3.0 Ortho Diagnostic and INNO-LIA HCV Ab III Innogenetics) among patients infected with different hepatitis C virus genotypes, with or without cryoglobulinemia, and in patients treated with interferon. METHODS:One hu...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0168-8278(98)80275-4

    authors： Frangeul L,Cresta P,Perrin M,Duverlie G,Khorsi H,Musset L,Opolon P,Huraux JM,Lunel F

    更新日期：1998-04-01 00:00:00

  • Early tacrolimus exposure after liver transplantation: relationship with moderate/severe acute rejection and long-term outcome.

    abstract：BACKGROUND & AIMS:Liver transplant (LT) patients might be overimmunosuppressed as recommendations for tacrolimus trough concentrations (TC) within 4-6 weeks after liver transplantation are set too high (10-15 ng/ml). Early tacrolimus exposure was evaluated in relation to acute rejection and long-term outcomes. METHODS...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.09.019

    authors： Rodríguez-Perálvarez M,Germani G,Papastergiou V,Tsochatzis E,Thalassinos E,Luong TV,Rolando N,Dhillon AP,Patch D,O'Beirne J,Thorburn D,Burroughs AK

    更新日期：2013-02-01 00:00:00

  • A study of fatty liver disease and plasma lipoproteins in a kindred with familial hypobetalipoproteinemia due to a novel truncated form of apolipoprotein B (APO B-54.5).

    abstract：BACKGROUND/AIMS:Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder characterized by reduced plasma levels of low-density lipoproteins. It can be caused by mutations in the gene encoding apolipoprotein B-100 (apo B), leading to the formation of truncated apo Bs which have a reduced capacity to export lipi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(00)80270-6

    authors： Tarugi P,Lonardo A,Ballarini G,Erspamer L,Tondelli E,Bertolini S,Calandra S

    更新日期：2000-09-01 00:00:00

  • The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin.

    abstract：BACKGROUND/AIMS:Selective cyclooxygenase (COX)-2 inhibitors do not adversely affect renal function in experimental cirrhosis. In the current study, we investigated the molecular mechanisms underlying the effects of the selective COX-2 inhibitor, celecoxib, and assessed the influence of albumin on its actions. METHODS:...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.09.011

    authors： López-Parra M,Clària J,Titos E,Planagumà A,Párrizas M,Masferrer JL,Jiménez W,Arroyo V,Rivera F,Rodés J

    更新日期：2005-01-01 00:00:00

  • Aquaretic agents: a new potential treatment of dilutional hyponatremia in cirrhosis.

    abstract：:An impairment in the renal capacity to excrete water is a common finding in patients with cirrhosis and ascites. In some patients this abnormality is minor since it is only detectable by measuring urine volume or free water clearance after a water load and is not associated with changes in plasma osmolality and serum ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(96)80174-7

    authors： Ginès P,Jiménez W

    更新日期：1996-04-01 00:00:00

  • Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis.

    abstract：BACKGROUND/AIMS:Primary sclerosing cholangitis (PSC) is associated with a high risk of cholangiocarcinoma development. Efforts should be made to detect early neoplastic changes that can be radically treated by liver transplantation. METHODS:In this prospective case series we obtained brush cytology specimens from bile...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jhep.2006.05.010

    authors： Boberg KM,Jebsen P,Clausen OP,Foss A,Aabakken L,Schrumpf E

    更新日期：2006-10-01 00:00:00

  • Prolonged QTc interval and its relationship to autonomic cardiovascular reflexes in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:We have previously shown that an abnormality in cardiac autonomic reflexes (AN) is an independent predictor of mortality in patients with chronic liver disease. Aim of this study was to determine whether there was an association between prolonged QTc interval and cardiac AN. METHODS:Cardiac AN and QTc ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(01)00217-3

    authors： Puthumana L,Chaudhry V,Thuluvath PJ

    更新日期：2001-12-01 00:00:00