Abstract:
BACKGROUND/AIMS:Hepatitis C has been associated with a decrease in quality of life and with neurological abnormalities. The aim of our study was to investigate the relationship between quality of life and cognitive function. METHODS:Quality of life, clinical variables and neuropsychological function were evaluated in 120 patients with hepatitis C (mild chronic hepatitis, compensated cirrhosis and decompensated cirrhosis) and in healthy controls (n=40, in each group). RESULTS:Patients with chronic hepatitis or compensated cirrhosis showed a decrease in quality of life, in spite of unimpaired neuropsychological tests. Patients with decompensated cirrhosis exhibited a further decrease in quality of life and neuropsychological abnormalities. The decrease in quality of life was associated with the severity of liver failure, neuropsychological abnormalities and treatment with beta-blockers or diuretics. However, in the multivariable analysis, only treatment with beta-blockers or diuretics (which was limited to decompensated cirrhosis) was independently associated with quality of life. CONCLUSIONS:Hepatitis C causes a decrease in quality of life even in the absence of major cognitive impairment. The mechanisms that worsen quality of life are unknown. However, in cirrhotic outpatients with prior decompensations, treatment with beta-blockers or diuretics appears to have an important effect on quality of life.
journal_name
J Hepatoljournal_title
Journal of hepatologyauthors
Córdoba J,Flavià M,Jacas C,Sauleda S,Esteban JI,Vargas V,Esteban R,Guardia Jdoi
10.1016/s0168-8278(03)00189-2subject
Has Abstractpub_date
2003-08-01 00:00:00pages
231-8issue
2eissn
0168-8278issn
1600-0641pii
S0168827803001892journal_volume
39pub_type
杂志文章abstract:BACKGROUND/AIMS:To study effects of pharmacologic concentrations of azathioprine and 6-mercaptopurine (6-MP) on rat hepatocytes. METHODS:Hepatocytes cultured on matrigel were incubated with azathioprine or 6-MP; effects of putative protective agents were studied. Viability (LDH leakage), reduced (GSH) and oxidized glu...
journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
abstract:BACKGROUND/AIMS:Severe alcoholic hepatitis occurs mainly in patients with cirrhosis, and has a high death rate. Corticosteroid therapy has been particularly advocated as reducing mortality in patients with severe histologic lesions. However, identification of these patients is difficult, requiring transvenous liver bio...
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更新日期:2000-03-01 00:00:00
abstract:BACKGROUND/AIMS:Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood. Matrix metalloproteinase (MMP)-9 is implicated in various brain injuries. We hypothesized tha...
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pub_type: 杂志文章
doi:10.1016/j.jhep.2005.09.019
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND AIMS:In hepatitis C there is controversy over the linearity of the rate of progression and the significance of gender, mode of infection and viral factors. METHODS:2313 untreated patients with a reliable estimated duration of infection and liver fibrosis were included. Fibrosis progression was calculated us...
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更新日期:2001-05-01 00:00:00
abstract:BACKGROUND/AIMS:To relate severity of intoxication with allyl alcohol and acetaminophen to modulated hepatic gene expression of liver functions and regeneration. METHODS:Rats fasted for 12 h received acetaminophen 3.5 or 5.6 g per kg body weight, or allyl alcohol 100 or 125 microl by gastric tube, doses producing no a...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/s0168-8278(97)80296-6
更新日期:1997-07-01 00:00:00
abstract::The heart and liver are organs that are closely related in both health and disease. Patients who undergo liver transplantation may suffer from heart disease that is: (a) related to the original cause of the liver disease such as hemochromatosis, (b) related to the liver disease itself, or (c) related to other associat...
journal_title:Journal of hepatology
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
abstract:BACKGROUND/AIMS:Apoptosis of bile duct cells occurs in hepatic allografts and is correlated with acute rejection. bcl-2 protein counteracts apoptosis and prolongs cell survival. We therefore tested the expression of bcl-2 protein in bile ducts of liver grafts in comparison with those of liver cirrhosis. METHODS:115 bi...
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更新日期:1997-03-01 00:00:00
abstract:BACKGROUND/AIMS:To review our experience of thrombolytic therapy in patients with acute Budd Chiari syndrome (BCS). METHODS:Records of 10 patients with BCS, treated by thrombolysis over a 12-year period were retrospectively analysed for demographics, clinical presentation/duration, primary disease, thrombolytic regime...
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pub_type: 杂志文章,评审
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更新日期:1997-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
abstract:BACKGROUND/AIMS:Portal hypertension is associated with systemic vasodilatation and vascular hyporeactivity, and is reversed by inhibiting nitric oxide biosynthesis. Nitric oxide and calcitonin gene-related peptide are neurotransmitters of non-adrenergic non-cholinergic nerves. The role of nitric oxide and calcitonin ge...
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pub_type: 杂志文章
doi:10.1016/s0168-8278(98)80353-x
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND/AIMS:We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. METHODS:Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT)...
journal_title:Journal of hepatology
pub_type: 杂志文章
doi:10.1016/j.jhep.2006.09.020
更新日期:2007-03-01 00:00:00
abstract::The etiologic agent responsible for epidemics of enterically-transmitted non-A, non-B hepatitis has been molecularly characterized as the hepatitis E virus (HEV). The cloning of a portion of the Burma strain of HEV (HEV(B); 'Old World' strain) has been described together with the isolation of a contiguous overlapping ...
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pub_type: 杂志文章
doi:10.1016/0168-8278(91)90050-l
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND/AIMS:Bio-artificial liver support systems for treatment of hepatic failure require maintained expression of hepatocyte function in vitro. We studied cultures of human hepatocyte cell-lines proliferating within alginate beads, investigating the hypothesis that 3-dimensional cohesive colonies of hepatocyte cel...
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pub_type: 杂志文章
doi:10.1016/s0168-8278(00)00080-5
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND & AIMS:The mechanisms of treatment resistance to interferon (IFN) and ribavirin (Rib) combination therapy for hepatitis C virus (HCV) infection are not known. This study aims to gain insight into these mechanisms by exploring hepatic gene expression before and during treatment. METHODS:Liver biopsy was perf...
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
abstract::The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...
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pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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更新日期:2003-07-01 00:00:00
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-03-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Journal of hepatology
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
abstract:BACKGROUND & AIMS:Simeprevir is an oral hepatitis C virus (HCV) NS3/4A protease inhibitor approved for treatment of chronic HCV infection. Baseline NS3 polymorphisms in all patients and emerging mutations in patients who failed to achieve sustained virologic response (SVR) with simeprevir plus peginterferon/ribavirin (...
journal_title:Journal of hepatology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-03-01 00:00:00
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更新日期:2021-01-01 00:00:00