Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury.

abstract：BACKGROUND/AIMS:Chronic graft hepatitis occurs in 20-30% adults after liver transplantation but the prevalence and causes in children are not known. In adults, hepatitis C virus infection is prevalent prior to transplantation and recurrent infection is a frequent cause of graft dysfunction. The significance of the rece...

journal_title：Journal of hepatology

authors： Davison SM,Skidmore SJ,Collingham KE,Irving WL,Hubscher SG,Kelly DA

更新日期：1998-05-01 00:00:00

abstract：:We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but i...

journal_title：Journal of hepatology

authors： van 't Wout JW,Herrmann WA,de Vries RA,Stricker BH

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic hepatitis C patients infected by genotype 1 are the least responsive to combination therapy and therefore monitoring response is important in identifying non-responders quickly, permitting therapy discontinuation and avoiding side effects and costs. We examined the usefulness of measuring total ...

journal_title：Journal of hepatology

authors： Buti M,Mendez C,Schaper M,Sauleda S,Valdes A,Rodriguez-Frias F,Jardi R,Esteban R

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIM:Since patients with high viral load and HCV subtype 1b are known to respond poorly to interferon (IFN) therapy, the viral dynamics of HCV RNA after initiation of interferon therapy were examined in the present study with respect to two different administration regimens, once vs. twice a day. METHODS:Twe...

journal_title：Journal of hepatology

authors： Shiratori Y,Perelson AS,Weinberger L,Imazeki F,Yokosuka O,Nakata R,Ihori M,Hirota K,Ono N,Kuroda H,Motojima T,Nishigaki M,Omata M

更新日期：2000-08-01 00:00:00

abstract：:Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programmes for systematic immunisation against hepatitis B virus have also significantly brought down the ...

journal_title：Journal of hepatology

authors： Xiao J,Wang F,Wong NK,He J,Zhang R,Sun R,Xu Y,Liu Y,Li W,Koike K,He W,You H,Miao Y,Liu X,Meng M,Gao B,Wang H,Li C

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...

journal_title：Journal of hepatology

authors： Garcia-Tsao G,Bosch J,Kayali Z,Harrison SA,Abdelmalek MF,Lawitz E,Satapathy SK,Ghabril M,Shiffman ML,Younes ZH,Thuluvath PJ,Berzigotti A,Albillos A,Robinson JM,Hagerty DT,Chan JL,Sanyal AJ,IDN-6556-14 Investigators(‡).

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic variants of patatin-like phospholipase domain-containing 3 (PNPLA3) and diabetes are associated with liver disease severity, in patients with chronic hepatitis C (CHC) infection. We aimed at exploring their interaction in determining hepatitis C virus (HCV)-related liver fibrosis. METHODS:The...

journal_title：Journal of hepatology

authors： Huang CF,Dai CY,Yeh ML,Huang CI,Tai CM,Hsieh MH,Liang PC,Lin YH,Hsieh MY,Yang HL,Huang JF,Lin ZY,Chen SC,Yu ML,Chuang WL

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:IL28B polymorphisms, jaundice, decline in HCV-RNA, IP-10, and gender have been proposed to be indicative of spontaneous clearance of acute hepatitis C virus infection. The aim of this study was to define a score enabling the discrimination of patients with spontaneous clearance of HCV from those with ...

journal_title：Journal of hepatology

authors： Beinhardt S,Payer BA,Datz C,Strasser M,Maieron A,Dorn L,Grilnberger-Franz E,Dulic-Lakovic E,Stauber R,Laferl H,Aberle JH,Holzmann H,Krall C,Vogel W,Ferenci P,Hofer H

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatomegaly can be triggered by insulin and insulin-unrelated etiologies. Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown. METHODS:Since many hepatomegaly-inducing toxicants and stressors activate NRF2, we examined the effect of NRF2 activation on liver size and metaboli...

journal_title：Journal of hepatology

authors： He F,Antonucci L,Yamachika S,Zhang Z,Taniguchi K,Umemura A,Hatzivassiliou G,Roose-Girma M,Reina-Campos M,Duran A,Diaz-Meco MT,Moscat J,Sun B,Karin M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND & AIMS:Liver stiffness (LS) as measured by transient elastography [Fibroscan] offers a novel non-invasive approach to assess liver cirrhosis. Since Fibroscan seems to be unreliable in patients with congestive heart failure, it remains to be determined whether hemodynamic changes affect LS irrespective of fib...

journal_title：Journal of hepatology

authors： Millonig G,Friedrich S,Adolf S,Fonouni H,Golriz M,Mehrabi A,Stiefel P,Pöschl G,Büchler MW,Seitz HK,Mueller S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIMS:The world-wide distribution of hepatitis B virus (HBV) genotypes follows a geographic pattern under the influence of ethnic background. METHODS:Forty eight core genes from four pacific islands were compared with the following findings. RESULTS:First, island-specific variant substitutions were found fo...

journal_title：Journal of hepatology

authors： Jazayeri MS,Basuni AA,Cooksley G,Locarnini S,Carman WF

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the nucleotide excision repair (NER) pathway in the resistance of human hepatocellular carcinoma (HCC) to chemotherapeutics. We investigated expression of several NER genes in human HCC and matching non-tumor tissue (NT) and in normal liver. METHODS:Expression of CSA, CSB, XPC, hH...

journal_title：Journal of hepatology

authors： Fautrel A,Andrieux L,Musso O,Boudjema K,Guillouzo A,Langouët S

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND/AIMS:Inflammation in the liver is a complex interaction between parenchymal and non-parenchymal cells, and therefore can not be studied in vitro in pure cultures of these cells. METHODS:We investigated whether Kupffer cells in the liver slice are still responsive to an inflammatory stimulus of lipopolysacch...

journal_title：Journal of hepatology

authors： Olinga P,Merema MT,de Jager MH,Derks F,Melgert BN,Moshage H,Slooff MJ,Meijer DK,Poelstra K,Groothuis GM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND & AIMS:Although liver fibrosis is an important predictor of outcomes for biliary atresia (BA), postsurgical native liver histology has not been well reported. Here, we retrospectively evaluated postsurgical native liver histology, and developed and assessed a novel scoring system - the BA liver fibrosis (BAL...

journal_title：Journal of hepatology

authors： Tomita H,Masugi Y,Hoshino K,Fuchimoto Y,Fujino A,Shimojima N,Ebinuma H,Saito H,Sakamoto M,Kuroda T

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & AIMS:A causal relationship between infection, systemic inflammation, and hepatic encephalopathy (HE) has been suggested in cirrhosis. No study, however, has specifically examined, in cirrhotic patients with infection, the complete pattern of clinical and subclinical cognitive alterations and its reversibil...

journal_title：Journal of hepatology

authors： Merli M,Lucidi C,Pentassuglio I,Giannelli V,Giusto M,Di Gregorio V,Pasquale C,Nardelli S,Lattanzi B,Venditti M,Riggio O

更新日期：2013-08-01 00:00:00

abstract：:MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to anatomically detailed morpho...

journal_title：Journal of hepatology

authors： Zhou IY,Catalano OA,Caravan P

更新日期：2020-11-01 00:00:00

abstract：:To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 patients with chronic liver disease and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 patients and 21 healthy subjects. Postprandial portal veno...

journal_title：Journal of hepatology

authors： de Vries PJ,de Hooge P,Hoekstra JB,van Hattum J

更新日期：1994-12-01 00:00:00

abstract：:In this report we describe the case of a 7-year-old boy, suffering from autoimmune-type chronic active hepatitis (AI-CAH) associated with vitiligo, nail dystrophy, alopecia areata and a variant of liver kidney microsomal (LKM) autoantibodies. This patient's antibodies are different from LKM-1 which are directed agains...

journal_title：Journal of hepatology

authors： Sacher M,Blümel P,Thaler H,Manns M

更新日期：1990-05-01 00:00:00

abstract：:The establishment of robust HCV cell culture systems and characterization of the viral life cycle provided the molecular basis for highly innovative, successful years in HCV drug development. With the identification of direct-acting antiviral agents (DAAs), such as NS3/4A protease inhibitors, NS5A replication complex ...

journal_title：Journal of hepatology

authors： Welzel TM,Dultz G,Zeuzem S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIMS:Liver macrophages play an essential role in necro-inflammatory liver damage which leads to fibrosis and cirrhosis. The aim of the present study was to compare the mediator release and the DNA synthesis of macrophages at an early and at a later stage of liver cirrhosis induced by thioacetamide. METHODS:...

journal_title：Journal of hepatology

authors： Vogl S,Junker U,Vogelsang H,Dargel R

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND & AIMS:Recently, the PAGE-B score and Toronto HCC risk index (THRI) have been developed to predict the risk of hepatocellular carcinoma (HCC) in Caucasian patients with chronic hepatitis B (CHB). We aimed to validate PAGE-B scores and THRI in Asian patients with CHB and suggested modified PAGE-B scores to im...

journal_title：Journal of hepatology

authors： Kim JH,Kim YD,Lee M,Jun BG,Kim TS,Suk KT,Kang SH,Kim MY,Cheon GJ,Kim DJ,Baik SK,Choi DH

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIMS:Evidence that the geno/subtype of hepatitis C virus (HCV) is predictive of the response to interferon-alpha therapy suggests that typing methods are clinically useful. In the present study, HCV isolates obtained from 74 patients with chronic hepatitis C were used to evaluate three genotyping and two ser...

journal_title：Journal of hepatology

authors： Lee JH,Roth WK,Zeuzem S

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND/AIMS:This study evaluates the agreement between reported use of interventions for patients with liver diseases and research evidence in Cochrane systematic reviews. METHODS:In July 2002, the Cochrane Hepato-Biliary Group had completed 28 systematic reviews on 36 interventions that were available in Denmark....

journal_title：Journal of hepatology

authors： Kürstein P,Gluud LL,Willemann M,Olsen KR,Kjellberg J,Sogaard J,Gluud C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND & AIMS:High oxidative stress plays a major role in increasing hepatic vascular resistance in cirrhosis, by facilitating liver fibrosis and by increasing hepatic vascular tone. This study is aimed at investigating whether the use of the novel isoform of recombinant human manganese superoxide dismutase (rMnSOD...

journal_title：Journal of hepatology

authors： Guillaume M,Rodriguez-Vilarrupla A,Gracia-Sancho J,Rosado E,Mancini A,Bosch J,Garcia-Pagán JC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND/AIMS:Whether GB virus C and hepatitis G virus participate in fulminant hepatic failure is controversial. We studied the prevalence of the viral RNA in 48 patients. There were possible routes of infection, including blood transfusion, in 22 patients (group 1), and no risk factors in the other 26 (group 2). M...

journal_title：Journal of hepatology

authors： Tanaka M,Nishiguchi S,Tanaka T,Enomoto M,Fukuda K,Takeda T,Nakajima S,Shiomi S,Kuroki T,Monna T,Yano Y,Otani S

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND & AIMS:Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b. METHODS:We analyzed p...

journal_title：Journal of hepatology

authors： Kawaoka T,Hayes CN,Ohishi W,Ochi H,Maekawa T,Abe H,Tsuge M,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Tsunoda T,Nakamura Y,Kumada H,Chayama K

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

journal_title：Journal of hepatology

authors： Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND & AIMS:Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease usually requiring life-long immunosuppression. The mechanisms for disease initiation and chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the blood was controversially discussed recently. So far i...

journal_title：Journal of hepatology

authors： Taubert R,Hardtke-Wolenski M,Noyan F,Wilms A,Baumann AK,Schlue J,Olek S,Falk CS,Manns MP,Jaeckel E

更新日期：2014-11-01 00:00:00

abstract：:Recently, GBV-C and HGV-two isolates of the same new flavivirus-were identified in serum samples of patients with indeterminate hepatitis and posttransfusion hepatitis, respectively. The pathogenic relevance of these viruses is still uncertain. As viral infections are presumed to trigger autoimmune processes, we inves...

journal_title：Journal of hepatology

authors： Heringlake S,Tillmann HL,Cordes-Temme P,Trautwein C,Hunsmann G,Manns MP

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND/AIMS:Patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) are at risk of early death due to end-stage liver failure. The aim of this study was to compare model of end-stage liver disease (MELD) and Child-Pugh scores as predictors of survival after TIPS. METHODS:We studied 140 cirrhotic p...

journal_title：Journal of hepatology

authors： Salerno F,Merli M,Cazzaniga M,Valeriano V,Rossi P,Lovaria A,Meregaglia D,Nicolini A,Lubatti L,Riggio O

更新日期：2002-04-01 00:00:00