当前位置： SCI文献检索 > JOURNAL OF HEPATOLOGY期刊下所有文献 > The apoptosis protector, bcl-2 protein, is downregulated in bile duct epithelial cells of human liver allografts.

The apoptosis protector, bcl-2 protein, is downregulated in bile duct epithelial cells of human liver allografts.

Abstract：

BACKGROUND/AIMS:Apoptosis of bile duct cells occurs in hepatic allografts and is correlated with acute rejection. bcl-2 protein counteracts apoptosis and prolongs cell survival. We therefore tested the expression of bcl-2 protein in bile ducts of liver grafts in comparison with those of liver cirrhosis. METHODS:115 biopsies from 17 liver allografts and 47 biopsies of liver cirrhosis were analyzed and compared with 22 normal controls and with biopsies from patients with primary sclerosing cholangitis or primary biliary cirrhosis. bcl-2 protein and PCNA (proliferating cell nuclear antigen) expression was assessed using immunohistochemistry, and apoptosis was analyzed employing in situ DNA end-labeling. RESULTS:A high apoptotic rate was detected in bile duct cells of allograft biopsies. In contrast to controls, bile duct cells of allografts and liver cirrhosis had high proliferative activity (mean PCNA labeling index: 1.0% vs. 40.7% and 18.6%, respectively). In liver grafts, bcl-2 protein positivity of bile duct and ductular cells was found in 3.6% and 4.4% of sections, respectively, and in cirrhosis in 44% and 79%, respectively (allografts vs. cirrhosis p<0.01). In controls, only one biopsy was bcl-2 positive. CONCLUSIONS:Whereas increased proliferative activity of small bile ducts and ductules in cirrhosis is associated with a high degree of bcl-2 expression, bile duct and ductular cells in liver grafts have a very low bcl-2 protein reactivity, even though their proliferative activity is high. These findings suggest that downregulation of bcl-2 expression in allograft bile duct cells might play a role in the increased apoptosis of these cells in acute rejection.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Gapany C,Zhao M,Zimmermann A

doi

10.1016/s0168-8278(97)80418-7

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

535-42

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(97)80418-7

journal_volume

26

pub_type

杂志文章

相关文献

JOURNAL OF HEPATOLOGY文献大全
  • The role of the Concanavalin A-binding fraction in cholesterol crystallization in native human bile.

    abstract：BACKGROUND/AIMS:Many Concanavalin A-binding glycoproteins have been proposed to influence cholesterol crystallization in human bile. This has been studied mainly by addition of the Concanavalin A-binding fraction to model bile. The physiological relevance of the proteins in native bile is not yet known. The aim of this...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(97)80148-1

    authors： Keulemans YC,Mok KS,Gouma DJ,Groen AK

    更新日期：1997-12-01 00:00:00

  • All-cause and liver-related mortality in HIV positive subjects compared to the general population: differences by HCV co-infection.

    abstract：BACKGROUND & AIMS:We aimed at comparing overall and liver-related mortality rates, observed in HIV positive subjects followed-up in the Cohorts of Spanish Network on HIV/AIDS Research stratified by HCV co-infection status, with the expected mortality of the general population of same age and sex in Spain, for the perio...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.06.010

    authors： Hernando V,Perez-Cachafeiro S,Lewden C,Gonzalez J,Segura F,Oteo JA,Rubio R,Dalmau D,Moreno S,Amo JD,CoRIS.

    更新日期：2012-10-01 00:00:00

  • Comparison of anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France. French Multicentre Group.

    abstract：:Two groups of patients with HBV DNA-positive chronic active hepatitis B, from 20 French hospitals, separated according to HBe status, were prospectively subjected to a comparative analysis of various epidemiological, clinical, biochemical, serologic and histologic features. There were 61 patients with anti-HBe and 215...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(05)80352-6

    authors： Zarski JP,Marcellin P,Cohard M,Lutz JM,Bouche C,Rais A

    更新日期：1994-05-01 00:00:00

  • Hepatitis C virus in kidney recipients. Epidemiology and impact on renal transplantation.

    abstract：:In an attempt to evaluate the prevalence, kinetics and impact of HCV infection in renal transplantation, we analyzed 140 kidney recipients according to the histopathological status of the liver. Thirty-three HBsAg-negative patients had chronic active hepatitis, 73 HBsAg-negative patients had a normal liver, 21 HBsAg-n...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(92)90036-o

    authors： Pol S,Legendre C,Saltiel C,Carnot F,Bréchot C,Berthelot P,Mattlinger B,Kreis H

    更新日期：1992-05-01 00:00:00

  • Detection of antibodies against pre-S1 proteins in sera of patients with hepatitis B virus (HBV) infection.

    abstract：:Pre-S1 (large S) proteins are components of the envelope of HBV. The presence of pre-S1 proteins is correlated with viral replication. To test sera of patients with HBV infection for the presence of antibodies against pre-S1 proteins (anti-pre-S1), an E. coli extract containing a pre-S fusion protein covering the grea...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80005-3

    authors： Theilmann L,Klinkert MQ,Gmelin K,Kommerell B,Pfaff E

    更新日期：1987-02-01 00:00:00

  • Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.

    abstract：BACKGROUND & AIMS:Sepsis is an acute systemic inflammatory response to infection associated with high patient mortality (28-40%). We hypothesized that interleukin (IL)-30, a novel cytokine protecting mice against liver injury resulting from inflammation, would generate a protective effect against systemic inflammation ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.12.020

    authors： Yan J,Mitra A,Hu J,Cutrera JJ,Xia X,Doetschman T,Gagea M,Mishra L,Li S

    更新日期：2016-05-01 00:00:00

  • Expression of HLA antigens and T cell infiltrates in chronic viral hepatitis. A comparison of biopsy and fine-needle aspiration findings.

    abstract：:To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/0168-8278(91)90937-7

    authors： Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

    更新日期：1991-03-01 00:00:00

  • Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis.

    abstract：BACKGROUND/AIMS:Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of chronic liver disease. Brain monoamines have been implicated in the pathogenesis of HE. We examined the relationship between monoamine dysfunction and the degree of portal-systemic shunting (PSS) in rats with varying degrees of PS...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.01.003

    authors： Lozeva V,Montgomery JA,Tuomisto L,Rocheleau B,Pannunzio M,Huet PM,Butterworth RF

    更新日期：2004-05-01 00:00:00

  • Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth.

    abstract：BACKGROUND & AIMS:Histopathology is the gold standard in the diagnosis of liver diseases but may be complicated by sampling error and bleeding. Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology. Previous studies using CLE for liver microscopy suffered from limited imaging depth...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.01.039

    authors： Goetz M,Deris I,Vieth M,Murr E,Hoffman A,Delaney P,Galle PR,Neurath MF,Kiesslich R

    更新日期：2010-07-01 00:00:00

  • Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C.

    abstract：BACKGROUND & AIMS:Insulin resistance, fibrosis and steatosis are established predictors of response to peg-interferon/ribavirin therapy in chronic hepatitis C (CHC). Several host genetic polymorphisms (IL28B, PNPLA3) modify treatment-outcome, the degree of steatosis or fibrosis. The aim of our study was to evaluate the...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2012.04.036

    authors： Stättermayer AF,Rutter K,Beinhardt S,Scherzer TM,Stadlmayr A,Hofer H,Wrba F,Steindl-Munda P,Krebs M,Datz C,Trauner M,Ferenci P

    更新日期：2012-09-01 00:00:00

  • Early interplay of intra-hepatic iron and insulin resistance in children with non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:The liver is a crucial organ at the crossroads of iron and glucose metabolism. The aim of the study was to assess intra-hepatic iron in young patients with non-alcoholic fatty liver disease (NAFLD) and its association with insulin resistance and severity of liver damage. METHODS:Intrahepatic iron con...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.12.007

    authors： Manco M,Alisi A,Real JF,Equitani F,DeVito R,Valenti L,Nobili V

    更新日期：2011-09-01 00:00:00

  • Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. A clinical and experimental study.

    abstract：:We measured plasma abnormal prothrombin (des-gamma-carboxy prothrombin; DCP) levels in normal subjects and in patients with hepatocellular carcinoma and other various diseases using the enzyme-linked immunosorbent assay developed by Motohara et al. (Pediatr Res 1985; 19: 354-357). Fifty-eight percent of 52 patients wi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80546-9

    authors： Okuda H,Obata H,Nakanishi T,Furukawa R,Hashimoto E

    更新日期：1987-06-01 00:00:00

  • Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure.

    abstract：BACKGROUND & AIMS:Non-selective beta blockers (NSBBs) have been shown to have deleterious outcomes in patients with refractory ascites, alcoholic hepatitis and spontaneous bacterial peritonitis leading many physicians to stop the drug in these cases. Acute-on-chronic liver failure (ACLF) is characterized by systemic in...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2015.10.018

    authors： Mookerjee RP,Pavesi M,Thomsen KL,Mehta G,Macnaughtan J,Bendtsen F,Coenraad M,Sperl J,Gines P,Moreau R,Arroyo V,Jalan R,CANONIC Study Investigators of the EASL-CLIF Consortium.

    更新日期：2016-03-01 00:00:00

  • Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis.

    abstract：:The peripheral arterial vasodilation hypothesis has been most influential in the field of cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in experimental and human cirrhosis and is the theoretical basis of life-saving treatments. It is undisputed that splanchnic arterial va...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2015.07.004

    authors： Bernardi M,Moreau R,Angeli P,Schnabl B,Arroyo V

    更新日期：2015-11-01 00:00:00

  • Evidence for Galalpha(1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems.

    abstract：BACKGROUND/AIMS:To bridge acute liver failure (ALF) patients to orthotopic liver transplantation, several bioartificial liver (BAL) systems have been developed. The bio-component of most BAL systems consists mainly of porcine hepatocytes. Plasma or blood of ALF patients is perfused through the BAL thereby contacting po...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.11.041

    authors： van de Kerkhove MP,Germans MR,Deurholt T,Hoekstra R,Joziasse DH,van Wijk AC,van Gulik TM,Chamuleau RA,Roos A

    更新日期：2005-04-01 00:00:00

  • Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe.

    abstract：BACKGROUND & AIMS:Antibiotic resistance has been increasingly reported in patients with decompensated cirrhosis in single-center studies. Prospective investigations reporting broad epidemiological data are scarce. We aimed to analyze epidemiological changes in bacterial infections in patients with decompensated cirrhos...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2018.10.027

    authors： Fernández J,Prado V,Trebicka J,Amoros A,Gustot T,Wiest R,Deulofeu C,Garcia E,Acevedo J,Fuhrmann V,Durand F,Sánchez C,Papp M,Caraceni P,Vargas V,Bañares R,Piano S,Janicko M,Albillos A,Alessandria C,Soriano G,Welz

    更新日期：2019-03-01 00:00:00

  • Aquaretic agents: a new potential treatment of dilutional hyponatremia in cirrhosis.

    abstract：:An impairment in the renal capacity to excrete water is a common finding in patients with cirrhosis and ascites. In some patients this abnormality is minor since it is only detectable by measuring urine volume or free water clearance after a water load and is not associated with changes in plasma osmolality and serum ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8278(96)80174-7

    authors： Ginès P,Jiménez W

    更新日期：1996-04-01 00:00:00

  • Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies.

    abstract：BACKGROUND & AIMS:Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease usually requiring life-long immunosuppression. The mechanisms for disease initiation and chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the blood was controversially discussed recently. So far i...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2014.05.034

    authors： Taubert R,Hardtke-Wolenski M,Noyan F,Wilms A,Baumann AK,Schlue J,Olek S,Falk CS,Manns MP,Jaeckel E

    更新日期：2014-11-01 00:00:00

  • Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study.

    abstract：BACKGROUND & AIMS:Alcoholic hepatitis is an acute life- and health-threatening disease that may be increasingly frequent. However, accurate and representative data on time trends in its incidence and prognosis are not available. This study aims to provide nationwide population-based estimates of alcoholic hepatitis inc...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2010.07.016

    authors： Sandahl TD,Jepsen P,Thomsen KL,Vilstrup H

    更新日期：2011-04-01 00:00:00

  • Pediatric gallstone disease in familial hypobetalipoproteinemia.

    abstract：:Familial hypobetalipoproteinemia (FHBL) is an monogenic co-dominant disorder characterized by reduced plasma levels of cholesterol, low density lipoproteins (LDL) and apolipoprotein B (apoB) often associated with non-alcoholic fatty liver disease (NAFLD). It has been suggested that FHBL might predispose to gallstone d...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2005.03.012

    authors： Lancellotti S,Zaffanello M,Di Leo E,Costa L,Lonardo A,Tarugi P

    更新日期：2005-07-01 00:00:00

  • New challenges in hepatic fibrosis.

    abstract：:Treatment of hepatic fibrosis by simple and inexpensive therapies is a new challenge for the near future. Hepatic fibrosis which may lead to cirrhosis, is indeed associated with most chronic liver diseases and affects millions of people. During the last decade, major breakthroughs have been accomplished in the field o...

    journal_title：Journal of hepatology

    pub_type： 评论,杂志文章,评审

    doi：10.1016/s0168-8278(05)80002-9

    authors： Clément B,Loréal O,Levavasseur F,Guillouzo A

    更新日期：1993-04-01 00:00:00

  • Chronic active hepatitis caused by benzarone.

    abstract：:We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. Jaundice and serum alanine aminotransferase activity increased while drug administration was continued, but promptly decreased when it was eventually interrupted. L...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(87)80039-9

    authors： Babany G,Larrey D,Pessayre D,Degott C,Rueff B,Benhamou JP

    更新日期：1987-12-01 00:00:00

  • Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia.

    abstract：BACKGROUND & AIMS:Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mechanisms used by cytotoxi...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2013.09.021

    authors： Shivakumar P,Mourya R,Bezerra JA

    更新日期：2014-02-01 00:00:00

  • Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy.

    abstract：BACKGROUND/AIMS:Hepatobiliary malignancies are frequently seen in primary sclerosing cholangitis (PSC) and they complicate the evaluation of patients and timing of liver transplantation. METHODS:Data from all Nordic PSC patients listed for liver transplantation during 1990-2001 were recorded prospectively. Predictors ...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2004.01.002

    authors： Brandsaeter B,Isoniemi H,Broomé U,Olausson M,Bäckman L,Hansen B,Schrumpf E,Oksanen A,Ericzon BG,Höckerstedt K,Mäkisalo H,Kirkegaard P,Friman S,Bjøro K

    更新日期：2004-05-01 00:00:00

  • Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension.

    abstract：:Portal hypertension is the main cause of complications in patients with chronic liver disease. Over the past 25 years, progress in the understanding of the pathophysiology of portal hypertension was followed by the introduction of an effective pharmacological therapy, consisting mainly of treatments aimed at correctin...

    journal_title：Journal of hepatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jhep.2010.03.021

    authors： Bosch J,Abraldes JG,Fernández M,García-Pagán JC

    更新日期：2010-09-01 00:00:00

  • A specific immune response to purified HA antigen (HAAg) demonstrated by leukocyte migration inhibition in patients recovering from viral hepatitis A.

    abstract：:The mechanism responsible for liver cell necrosis in patients with hepatitis A is not known. Since the type of hepatic lesions and the clinical presentation of acute hepatitis B are similar and are probably related to the cell-mediated immune response to a viral antigen located in the liver cell, it is possible that a...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(86)80082-4

    authors： Fasel-Folley J,Overby LR,Frei PC

    更新日期：1986-01-01 00:00:00

  • Variability of splanchnic blood flow measurements using MR velocity mapping under fasting and post-prandial conditions--comparison with echo-Doppler.

    abstract：BACKGROUND/AIMS:The aim was to study the reproducibility of magnetic resonance velocity mapping, when measuring portal vein and superior mesenteric artery blood flow, under fasting and post-prandial conditions. Magnetic resonance flow measurements for the portal vein were compared with echo-Doppler measurements in the ...

    journal_title：Journal of hepatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8278(97)80045-1

    authors： Lycklama à Nijeholt GJ,Burggraaf K,Wasser MN,Schultze Kool LJ,Schoemaker RC,Cohen AF,de Roos A

    更新日期：1997-02-01 00:00:00

  • Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.

    abstract：BACKGROUND & AIMS:In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLK...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2019.11.008

    authors： Majdi A,Aoudjehane L,Ratziu V,Islam T,Afonso MB,Conti F,Mestiri T,Lagouge M,Foufelle F,Ballenghien F,Ledent T,Moldes M,Cadoret A,Fouassier L,Delaunay JL,Aït-Slimane T,Courtois G,Fève B,Scatton O,Prip-Buus C,Rodrig

    更新日期：2020-04-01 00:00:00

  • Resistance to indomethacin-induced down-regulation of hepatic cytochrome P450 enzymes in the mice with non-functional Toll-like receptor 4.

    abstract：BACKGROUND/AIMS:Repetitive indomethacin administration induces down-regulation of hepatic cytochrome P450 (CYP) enzymes. We tested the hypothesis that an increase in intestinal permeability by indomethacin-induced intestinal injury leads to entry of bacterial endotoxin and reaching into liver via the portal vein, resul...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00244-7

    authors： Masubuchi Y,Horie T

    更新日期：2003-09-01 00:00:00

  • Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients.

    abstract：BACKGROUND & AIMS:Innate sensing of viral infection activates a global defense response including type I interferon (IFN) and IFN-stimulated genes (ISGs) expression. We previously reported that HCV NS3/4A protease, an essential protein in viral polyprotein processing, can abrogate antiviral signaling pathways and effec...

    journal_title：Journal of hepatology

    pub_type： 杂志文章

    doi：10.1016/j.jhep.2011.07.017

    authors： Jouan L,Chatel-Chaix L,Melançon P,Rodrigue-Gervais IG,Raymond VA,Selliah S,Bilodeau M,Grandvaux N,Lamarre D

    更新日期：2012-01-01 00:00:00