Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.

Abstract:

BACKGROUND/AIMS:We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. METHODS:Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT), APRI, FibroMeter (FM), and Hepascore (HS). RESULTS:Metavir stages were: F0: 4%, F1: 55%, F2: 26%, F3: 11%, and F4: 4%. The AUROCs were not significantly different, respectively, FT, FM, APRI, HS: >or=F2: 0.79, 0.78, 0.76, >or=0.76; F3: 0.81, 0.85, 0.81, 0.81; and F4: 0.86, 0.94, 0.92, 0.89. The TPP relies on the paired comparison of blood-test misclassification based on liver specimen, e.g. FT vs FM, respectively: F0+1: 18 vs 28% (p=0.0003), >or=F2: 43 vs 31% (p=0.004). There was no center effect. CONCLUSIONS:In those populations, the four blood tests had a similar performance for significant fibrosis (F>or=2), lying in the lower range of published results which is attributable to a low >or=F2 prevalence, and for >or=F3 and F4. However, FM and FT had performance profiles significantly different as a function of fibrosis stages or diagnostic target (fibrosis cut-off). This has to be considered during the interpretation process. Moreover, the performance should be reported with different diagnostic targets.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Halfon P,Bacq Y,De Muret A,Penaranda G,Bourliere M,Ouzan D,Tran A,Botta D,Renou C,Bréchot MC,Degott C,Paradis V

doi

10.1016/j.jhep.2006.09.020

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

395-402

issue

3

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(06)00573-3

journal_volume

46

pub_type

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